Inhibitor of growth tumor suppressors in cancer progression
The inhibitor of growth (ING) family of tumor suppressors has five members and is implicated in the control of apoptosis, senescence, DNA repair, and cancer progression. However, little is known about ING activity in the regulation of cancer progression. ING members and splice variants seem to behav...
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| Veröffentlicht in: | Cellular and molecular life sciences : CMLS 2010-06, Vol.67 (12), p.1987-1999 |
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| container_end_page | 1999 |
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| container_issue | 12 |
| container_start_page | 1987 |
| container_title | Cellular and molecular life sciences : CMLS |
| container_volume | 67 |
| creator | Piche, Brad Li, Gang |
| description | The inhibitor of growth (ING) family of tumor suppressors has five members and is implicated in the control of apoptosis, senescence, DNA repair, and cancer progression. However, little is known about ING activity in the regulation of cancer progression. ING members and splice variants seem to behave differently with respect to cancer invasion and metastasis. Interaction with histone trimethylated at lysine 4 (H3K4me3), hypoxia inducible factor-1 (HIF-1), p53, and nuclear factor kappa-B (NF-κB) are potential mechanisms by which ING members exert effects on invasion and metastasis. Subcellular mislocalization, rapid protein degradation, and to a lesser extent ING gene mutation are among the mechanisms responsible for inappropriate ING levels in cancer cells. The aim of this review is to summarize the different roles of ING family tumor suppressors in cancer progression and the molecular mechanisms involved. |
| doi_str_mv | 10.1007/s00018-010-0312-z |
| format | Article |
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However, little is known about ING activity in the regulation of cancer progression. ING members and splice variants seem to behave differently with respect to cancer invasion and metastasis. Interaction with histone trimethylated at lysine 4 (H3K4me3), hypoxia inducible factor-1 (HIF-1), p53, and nuclear factor kappa-B (NF-κB) are potential mechanisms by which ING members exert effects on invasion and metastasis. Subcellular mislocalization, rapid protein degradation, and to a lesser extent ING gene mutation are among the mechanisms responsible for inappropriate ING levels in cancer cells. The aim of this review is to summarize the different roles of ING family tumor suppressors in cancer progression and the molecular mechanisms involved.</description><identifier>ISSN: 1420-682X</identifier><identifier>EISSN: 1420-9071</identifier><identifier>DOI: 10.1007/s00018-010-0312-z</identifier><identifier>PMID: 20195696</identifier><language>eng</language><publisher>Basel: Basel : SP Birkhäuser Verlag Basel</publisher><subject>Animals ; Apoptosis - genetics ; Apoptosis - physiology ; Biochemistry ; Biodegradation ; Biomedical and Life Sciences ; Biomedicine ; Cancer progression ; Cell Biology ; Cellular biology ; DNA Repair ; Growth - genetics ; Growth Inhibitors - genetics ; Growth Inhibitors - physiology ; Histones - genetics ; Histones - metabolism ; Humans ; Hypoxia ; ING ; Invasion ; Life Sciences ; metastasis ; Molecular biology ; Mutation ; Neoplasms - genetics ; Neoplastic Processes ; NF-kappa B - genetics ; NF-kappa B - metabolism ; Oncology ; Review ; Tumor suppressor ; Tumor Suppressor Protein p53 - genetics ; Tumor Suppressor Protein p53 - metabolism ; Tumors</subject><ispartof>Cellular and molecular life sciences : CMLS, 2010-06, Vol.67 (12), p.1987-1999</ispartof><rights>Springer Basel AG 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c493t-6133dcdaea76d5bfbe419f36b35ddd058c3aa095d6fdac7c5147196c3bc195d83</citedby><cites>FETCH-LOGICAL-c493t-6133dcdaea76d5bfbe419f36b35ddd058c3aa095d6fdac7c5147196c3bc195d83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11115670/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11115670/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,41488,42557,51319,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20195696$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Piche, Brad</creatorcontrib><creatorcontrib>Li, Gang</creatorcontrib><title>Inhibitor of growth tumor suppressors in cancer progression</title><title>Cellular and molecular life sciences : CMLS</title><addtitle>Cell. Mol. Life Sci</addtitle><addtitle>Cell Mol Life Sci</addtitle><description>The inhibitor of growth (ING) family of tumor suppressors has five members and is implicated in the control of apoptosis, senescence, DNA repair, and cancer progression. However, little is known about ING activity in the regulation of cancer progression. ING members and splice variants seem to behave differently with respect to cancer invasion and metastasis. Interaction with histone trimethylated at lysine 4 (H3K4me3), hypoxia inducible factor-1 (HIF-1), p53, and nuclear factor kappa-B (NF-κB) are potential mechanisms by which ING members exert effects on invasion and metastasis. Subcellular mislocalization, rapid protein degradation, and to a lesser extent ING gene mutation are among the mechanisms responsible for inappropriate ING levels in cancer cells. The aim of this review is to summarize the different roles of ING family tumor suppressors in cancer progression and the molecular mechanisms involved.</description><subject>Animals</subject><subject>Apoptosis - genetics</subject><subject>Apoptosis - physiology</subject><subject>Biochemistry</subject><subject>Biodegradation</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer progression</subject><subject>Cell Biology</subject><subject>Cellular biology</subject><subject>DNA Repair</subject><subject>Growth - genetics</subject><subject>Growth Inhibitors - genetics</subject><subject>Growth Inhibitors - physiology</subject><subject>Histones - genetics</subject><subject>Histones - metabolism</subject><subject>Humans</subject><subject>Hypoxia</subject><subject>ING</subject><subject>Invasion</subject><subject>Life Sciences</subject><subject>metastasis</subject><subject>Molecular biology</subject><subject>Mutation</subject><subject>Neoplasms - genetics</subject><subject>Neoplastic Processes</subject><subject>NF-kappa B - genetics</subject><subject>NF-kappa B - metabolism</subject><subject>Oncology</subject><subject>Review</subject><subject>Tumor suppressor</subject><subject>Tumor Suppressor Protein p53 - genetics</subject><subject>Tumor Suppressor Protein p53 - metabolism</subject><subject>Tumors</subject><issn>1420-682X</issn><issn>1420-9071</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kUtv1TAQhS1ERUvhB7CBiA2r0Bk7dmKxQKjiUalSF1CJneXYTq6re-1gJyD66_FVLgW6wBs_5jvHMzqEPEN4jQDtWQYA7GpAqIEhrW8fkBNsKNQSWnx4OIuOfj0mj3O-KTDvqHhEjimg5EKKE_LmImx87-eYqjhUY4o_5k01L7tyz8s0JZdzTLnyoTI6GJeqKcVx_-pjeEKOBr3N7ulhPyXXH95_Of9UX159vDh_d1mbRrK5FsiYNVY73QrL-6F3DcqBiZ5xay3wzjCtQXIrBqtNazg2LUphWG9Kl7Zjp-Tt6jst_c5Z48Kc9FZNye90-qmi9urfSvAbNcbvCsviooXi8OrgkOK3xeVZ7Xw2brvVwcUlq5YxkBQ5FvLlPfImLimU8RTjQnAOVBYIV8ikmHNyw10vCGqfjFqTUSUZtU9G3RbN87-HuFP8jqIAdAVyKYXRpT8__8_1xSoadFR6TD6r68_FkhWu6VhH2S889aRB</recordid><startdate>20100601</startdate><enddate>20100601</enddate><creator>Piche, Brad</creator><creator>Li, Gang</creator><general>Basel : SP Birkhäuser Verlag Basel</general><general>SP Birkhäuser Verlag Basel</general><general>Springer Nature B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SS</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>P64</scope><scope>PATMY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20100601</creationdate><title>Inhibitor of growth tumor suppressors in cancer progression</title><author>Piche, Brad ; Li, Gang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c493t-6133dcdaea76d5bfbe419f36b35ddd058c3aa095d6fdac7c5147196c3bc195d83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Animals</topic><topic>Apoptosis - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cellular and molecular life sciences : CMLS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Piche, Brad</au><au>Li, Gang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inhibitor of growth tumor suppressors in cancer progression</atitle><jtitle>Cellular and molecular life sciences : CMLS</jtitle><stitle>Cell. Mol. Life Sci</stitle><addtitle>Cell Mol Life Sci</addtitle><date>2010-06-01</date><risdate>2010</risdate><volume>67</volume><issue>12</issue><spage>1987</spage><epage>1999</epage><pages>1987-1999</pages><issn>1420-682X</issn><eissn>1420-9071</eissn><abstract>The inhibitor of growth (ING) family of tumor suppressors has five members and is implicated in the control of apoptosis, senescence, DNA repair, and cancer progression. However, little is known about ING activity in the regulation of cancer progression. ING members and splice variants seem to behave differently with respect to cancer invasion and metastasis. Interaction with histone trimethylated at lysine 4 (H3K4me3), hypoxia inducible factor-1 (HIF-1), p53, and nuclear factor kappa-B (NF-κB) are potential mechanisms by which ING members exert effects on invasion and metastasis. Subcellular mislocalization, rapid protein degradation, and to a lesser extent ING gene mutation are among the mechanisms responsible for inappropriate ING levels in cancer cells. The aim of this review is to summarize the different roles of ING family tumor suppressors in cancer progression and the molecular mechanisms involved.</abstract><cop>Basel</cop><pub>Basel : SP Birkhäuser Verlag Basel</pub><pmid>20195696</pmid><doi>10.1007/s00018-010-0312-z</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Cellular and molecular life sciences : CMLS, 2010-06, Vol.67 (12), p.1987-1999 |
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| subjects | Animals Apoptosis - genetics Apoptosis - physiology Biochemistry Biodegradation Biomedical and Life Sciences Biomedicine Cancer progression Cell Biology Cellular biology DNA Repair Growth - genetics Growth Inhibitors - genetics Growth Inhibitors - physiology Histones - genetics Histones - metabolism Humans Hypoxia ING Invasion Life Sciences metastasis Molecular biology Mutation Neoplasms - genetics Neoplastic Processes NF-kappa B - genetics NF-kappa B - metabolism Oncology Review Tumor suppressor Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Tumors |
| title | Inhibitor of growth tumor suppressors in cancer progression |
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