comparative analysis of the cell biology of senescence and aging
Various intracellular organelles, such as lysosomes, mitochondria, nuclei, and cytoskeletons, change during replicative senescence, but the utility of these changes as general markers of senescence and their significance with respect to functional alterations have not been comprehensively reviewed....
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| Veröffentlicht in: | Cellular and molecular life sciences : CMLS 2009-08, Vol.66 (15), p.2503-2524 |
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| creator | Hwang, Eun Seong Yoon, Gyesoon Kang, Hyun Tae |
| description | Various intracellular organelles, such as lysosomes, mitochondria, nuclei, and cytoskeletons, change during replicative senescence, but the utility of these changes as general markers of senescence and their significance with respect to functional alterations have not been comprehensively reviewed. Furthermore, the relevance of these alterations to cellular and functional changes in aging animals is poorly understood. In this paper, we review the studies that report these senescence-associated changes in various aging cells and their underlying mechanisms. Changes associated with lysosomes and mitochondria are found not only in cells undergoing replicative or induced senescence but also in postmitotic cells isolated from aged organisms. In contrast, other changes occur mainly in cells undergoing in vitro senescence. Comparison of age-related changes and their underlying mechanisms in in vitro senescent cells and aged postmitotic cells would reveal the relevance of replicative senescence to the physiological processes occurring in postmitotic cells as individuals age. |
| doi_str_mv | 10.1007/s00018-009-0034-2 |
| format | Article |
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Furthermore, the relevance of these alterations to cellular and functional changes in aging animals is poorly understood. In this paper, we review the studies that report these senescence-associated changes in various aging cells and their underlying mechanisms. Changes associated with lysosomes and mitochondria are found not only in cells undergoing replicative or induced senescence but also in postmitotic cells isolated from aged organisms. In contrast, other changes occur mainly in cells undergoing in vitro senescence. Comparison of age-related changes and their underlying mechanisms in in vitro senescent cells and aged postmitotic cells would reveal the relevance of replicative senescence to the physiological processes occurring in postmitotic cells as individuals age.</description><identifier>ISSN: 1420-682X</identifier><identifier>EISSN: 1420-9071</identifier><identifier>DOI: 10.1007/s00018-009-0034-2</identifier><identifier>PMID: 19421842</identifier><language>eng</language><publisher>Basel: Basel : SP Birkhäuser Verlag Basel</publisher><subject>Aging ; Aging - physiology ; Animals ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Cell Adhesion - physiology ; Cell Biology ; Cell Size ; Cellular biology ; Cellular Senescence - physiology ; Comparative analysis ; Cytoplasmic Granules - chemistry ; Cytoplasmic Granules - metabolism ; Cytoplasmic Granules - ultrastructure ; Cytoskeleton - chemistry ; Cytoskeleton - metabolism ; DNA Damage ; DNA Replication ; Fibroblasts - cytology ; Fibroblasts - physiology ; Heterochromatin - metabolism ; Heterochromatin - ultrastructure ; Humans ; Life Sciences ; Lysosomes - metabolism ; Lysosomes - ultrastructure ; Mitochondria - metabolism ; Mitochondria - ultrastructure ; Phenotype ; Progeria - metabolism ; Progeria - pathology ; Review ; Studies ; Telomere - metabolism</subject><ispartof>Cellular and molecular life sciences : CMLS, 2009-08, Vol.66 (15), p.2503-2524</ispartof><rights>Birkhäuser Verlag, Basel/Switzerland 2009</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c515t-291ee764e21c5b0125891c30a2fc93a831351cb0a94b90df6d595c7caa3f760c3</citedby><cites>FETCH-LOGICAL-c515t-291ee764e21c5b0125891c30a2fc93a831351cb0a94b90df6d595c7caa3f760c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11115533/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11115533/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,41464,42533,51294,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19421842$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hwang, Eun Seong</creatorcontrib><creatorcontrib>Yoon, Gyesoon</creatorcontrib><creatorcontrib>Kang, Hyun Tae</creatorcontrib><title>comparative analysis of the cell biology of senescence and aging</title><title>Cellular and molecular life sciences : CMLS</title><addtitle>Cell. Mol. Life Sci</addtitle><addtitle>Cell Mol Life Sci</addtitle><description>Various intracellular organelles, such as lysosomes, mitochondria, nuclei, and cytoskeletons, change during replicative senescence, but the utility of these changes as general markers of senescence and their significance with respect to functional alterations have not been comprehensively reviewed. Furthermore, the relevance of these alterations to cellular and functional changes in aging animals is poorly understood. In this paper, we review the studies that report these senescence-associated changes in various aging cells and their underlying mechanisms. Changes associated with lysosomes and mitochondria are found not only in cells undergoing replicative or induced senescence but also in postmitotic cells isolated from aged organisms. In contrast, other changes occur mainly in cells undergoing in vitro senescence. Comparison of age-related changes and their underlying mechanisms in in vitro senescent cells and aged postmitotic cells would reveal the relevance of replicative senescence to the physiological processes occurring in postmitotic cells as individuals age.</description><subject>Aging</subject><subject>Aging - physiology</subject><subject>Animals</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell Adhesion - physiology</subject><subject>Cell Biology</subject><subject>Cell Size</subject><subject>Cellular biology</subject><subject>Cellular Senescence - physiology</subject><subject>Comparative analysis</subject><subject>Cytoplasmic Granules - chemistry</subject><subject>Cytoplasmic Granules - metabolism</subject><subject>Cytoplasmic Granules - ultrastructure</subject><subject>Cytoskeleton - chemistry</subject><subject>Cytoskeleton - metabolism</subject><subject>DNA Damage</subject><subject>DNA Replication</subject><subject>Fibroblasts - cytology</subject><subject>Fibroblasts - physiology</subject><subject>Heterochromatin - metabolism</subject><subject>Heterochromatin - ultrastructure</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Lysosomes - metabolism</subject><subject>Lysosomes - ultrastructure</subject><subject>Mitochondria - metabolism</subject><subject>Mitochondria - ultrastructure</subject><subject>Phenotype</subject><subject>Progeria - metabolism</subject><subject>Progeria - pathology</subject><subject>Review</subject><subject>Studies</subject><subject>Telomere - metabolism</subject><issn>1420-682X</issn><issn>1420-9071</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kU1r3DAQhkVoaT7aH5BLa3LIze3MyLKlUxNCvyDQQxLoTcha2VHwWhvJG9h_XxkvTZtDBUKD5plXM3oZO0X4iADNpwQAKEsAlTevSjpgR1gRlAoafLWPa0m_DtlxSg8ZFpLqN-wQVUUoKzpiFzasNyaayT-5woxm2CWfitAV070rrBuGovVhCP1uvktudMm60c7oqjC9H_u37HVnhuTe7c8Tdvf1y-3V9_L657cfV5fXpRUoppIUOtfUlSO0ogUkIRVaDoY6q7iRHLlA24JRVatg1dUroYRtrDG8a2qw_IR9XnQ323btVrmLKZpBb6Jfm7jTwXj9b2b097oPTxrzEoLzrHC-V4jhcevSpNc-zSOa0YVt0nVTSckJMnj2AnwI25j_Jmma2yQlVYZwgWwMKUXX_WkFQc_u6MUdnd3Rszuacs37v2d4rtjbkQFagJRTY-_i88v_U_2wFHUmaNNHn_TdDQFywFrURIL_BnYyowE</recordid><startdate>20090801</startdate><enddate>20090801</enddate><creator>Hwang, Eun Seong</creator><creator>Yoon, Gyesoon</creator><creator>Kang, Hyun Tae</creator><general>Basel : SP Birkhäuser Verlag Basel</general><general>SP Birkhäuser Verlag Basel</general><general>Springer Nature B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SS</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>P64</scope><scope>PATMY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20090801</creationdate><title>comparative analysis of the cell biology of senescence and aging</title><author>Hwang, Eun Seong ; Yoon, Gyesoon ; Kang, Hyun Tae</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c515t-291ee764e21c5b0125891c30a2fc93a831351cb0a94b90df6d595c7caa3f760c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Aging</topic><topic>Aging - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cellular and molecular life sciences : CMLS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hwang, Eun Seong</au><au>Yoon, Gyesoon</au><au>Kang, Hyun Tae</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>comparative analysis of the cell biology of senescence and aging</atitle><jtitle>Cellular and molecular life sciences : CMLS</jtitle><stitle>Cell. Mol. Life Sci</stitle><addtitle>Cell Mol Life Sci</addtitle><date>2009-08-01</date><risdate>2009</risdate><volume>66</volume><issue>15</issue><spage>2503</spage><epage>2524</epage><pages>2503-2524</pages><issn>1420-682X</issn><eissn>1420-9071</eissn><abstract>Various intracellular organelles, such as lysosomes, mitochondria, nuclei, and cytoskeletons, change during replicative senescence, but the utility of these changes as general markers of senescence and their significance with respect to functional alterations have not been comprehensively reviewed. Furthermore, the relevance of these alterations to cellular and functional changes in aging animals is poorly understood. In this paper, we review the studies that report these senescence-associated changes in various aging cells and their underlying mechanisms. Changes associated with lysosomes and mitochondria are found not only in cells undergoing replicative or induced senescence but also in postmitotic cells isolated from aged organisms. In contrast, other changes occur mainly in cells undergoing in vitro senescence. Comparison of age-related changes and their underlying mechanisms in in vitro senescent cells and aged postmitotic cells would reveal the relevance of replicative senescence to the physiological processes occurring in postmitotic cells as individuals age.</abstract><cop>Basel</cop><pub>Basel : SP Birkhäuser Verlag Basel</pub><pmid>19421842</pmid><doi>10.1007/s00018-009-0034-2</doi><tpages>22</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; SpringerLink Journals; PubMed Central |
| subjects | Aging Aging - physiology Animals Biochemistry Biomedical and Life Sciences Biomedicine Cell Adhesion - physiology Cell Biology Cell Size Cellular biology Cellular Senescence - physiology Comparative analysis Cytoplasmic Granules - chemistry Cytoplasmic Granules - metabolism Cytoplasmic Granules - ultrastructure Cytoskeleton - chemistry Cytoskeleton - metabolism DNA Damage DNA Replication Fibroblasts - cytology Fibroblasts - physiology Heterochromatin - metabolism Heterochromatin - ultrastructure Humans Life Sciences Lysosomes - metabolism Lysosomes - ultrastructure Mitochondria - metabolism Mitochondria - ultrastructure Phenotype Progeria - metabolism Progeria - pathology Review Studies Telomere - metabolism |
| title | comparative analysis of the cell biology of senescence and aging |
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