Human mesenchymal stem cells induce E-cadherin degradation in breast carcinoma spheroids by activating ADAM10

Mesenchymal stem cells (MSCs) have been shown to communicate with tumor cells. We analyzed the effect of human MSCs (hMSCs) on breast cancer cells in three-dimensional cultures. By using GFP expression and immunohistochemistry, we show that hMSCs invade 3D breast cancer cell aggregates. hMSCs caused...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cellular and molecular life sciences : CMLS 2009-09, Vol.66 (18), p.3053-3065
Hauptverfasser:	Dittmer, Angela, Hohlfeld, Kristina, Lützkendorf, Jana, Müller, Lutz P, Dittmer, Jürgen
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus ADAM Proteins - metabolism ADAM Proteins - physiology ADAM10 Protein Adhesion Amyloid Precursor Protein Secretases - metabolism Amyloid Precursor Protein Secretases - physiology Biochemistry Biomedical and Life Sciences Biomedicine Breast cancer Breast Neoplasms - pathology Cadherins - metabolism Cell Adhesion Cell adhesion & migration Cell Biology Cell Movement Coculture Techniques Humans Life Sciences Membrane Proteins - metabolism Membrane Proteins - physiology Mesenchymal Stem Cells - metabolism Mitogen-Activated Protein Kinase 3 Research Article Stem cells Studies Translocation Tumor Cells, Cultured
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!