Eukaryotic DNA damage checkpoint activation in response to double-strand breaks

Double-strand breaks (DSBs) are the most detrimental form of DNA damage. Failure to repair these cytotoxic lesions can result in genome rearrangements conducive to the development of many diseases, including cancer. The DNA damage response (DDR) ensures the rapid detection and repair of DSBs in orde...

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Veröffentlicht in:	Cellular and molecular life sciences : CMLS 2012-05, Vol.69 (9), p.1447-1473
Hauptverfasser:	Finn, Karen, Lowndes, Noel Francis, Grenon, Muriel
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Biomedical and Life Sciences Biomedicine Cancer Cell Biology Cell cycle Cell Cycle - genetics Cell Cycle Checkpoints - genetics Cell Cycle Checkpoints - physiology Cell Cycle Proteins - metabolism Checkpoint Kinase 1 Checkpoint Kinase 2 Cytotoxicity Deoxyribonucleic acid DNA DNA Breaks, Double-Stranded DNA damage DNA Damage - genetics DNA Damage - physiology DNA repair Eukaryota - cytology Eukaryota - genetics Eukaryota - metabolism Eukaryotes Genomes Genomic Instability Humans Life Sciences Models, Biological Models, Genetic Molecular modelling Protein Kinases - metabolism Protein Serine-Threonine Kinases - metabolism Review Reviews Saccharomyces cerevisiae Saccharomyces cerevisiae - cytology Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - metabolism Signal transduction Signal Transduction - genetics Yeast Yeasts
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