An abundant, truncated human sulfonylurea receptor 1 splice variant has prodiabetic properties and impairs sulfonylurea action

An alternatively spliced form of human sulfonylurea receptor (SUR) 1 mRNA lacking exon 2 (SUR1Δ2) has been identified. The omission of exon 2 caused a frame shift and an immediate stop codon in exon 3 leading to translation of a 5.6-kDa peptide that comprises the N-terminal extracellular domain and...

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Veröffentlicht in:	Cellular and molecular life sciences : CMLS 2012-01, Vol.69 (1), p.129-148
Hauptverfasser:	Schmid, Diethart, Stolzlechner, Michael, Sorgner, Albin, Bentele, Caterina, Assinger, Alice, Chiba, Peter, Moeslinger, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative Splicing - physiology Animals ATP ATP-Binding Cassette Transporters - genetics ATP-Binding Cassette Transporters - metabolism Biochemistry Biomedical and Life Sciences Biomedicine Calcium - metabolism Cell Biology Chlorocebus aethiops COS Cells Diabetes Diabetes Mellitus, Type 2 - genetics Diabetes Mellitus, Type 2 - metabolism Diabetes Mellitus, Type 2 - physiopathology Exons - physiology Glyburide - pharmacology Humans Hypoglycemic Agents - pharmacology Insulin Insulin - metabolism Islets of Langerhans - metabolism KATP Channels - drug effects KATP Channels - metabolism Life Sciences Myocardium - metabolism Neurons Organ Specificity - genetics Pancreas - metabolism Polymorphism, Single Nucleotide Potassium Channels, Inwardly Rectifying - genetics Potassium Channels, Inwardly Rectifying - metabolism Rats Receptors, Drug - genetics Receptors, Drug - metabolism Relative abundance Research Article Ribonucleic acid RNA RNA, Messenger - genetics RNA, Messenger - metabolism Species Specificity Sulfonylurea Receptors
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