A synthetic lethal dependency on casein kinase 2 in response to replication-perturbing therapeutics in RB1-deficient cancer cells

Resistance to therapy commonly develops in patients with high-grade serous ovarian carcinoma (HGSC) and triple-negative breast cancer (TNBC), urging the search for improved therapeutic combinations and their predictive biomarkers. Starting from a CRISPR knockout screen, we identified that loss of RB...

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Veröffentlicht in:	Science advances 2024-05, Vol.10 (21), p.eadj1564-eadj1564
Hauptverfasser:	Bulanova, Daria, Akimov, Yevhen, Senkowski, Wojciech, Oikkonen, Jaana, Gall-Mas, Laura, Timonen, Sanna, Elmadani, Manar, Hynninen, Johanna, Hautaniemi, Sampsa, Aittokallio, Tero, Wennerberg, Krister
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Biomedicine and Life Sciences Cancer Carboplatin - pharmacology Casein Kinase II - antagonists & inhibitors Casein Kinase II - genetics Casein Kinase II - metabolism Cell Biology Cell Line, Tumor DNA Replication - drug effects Drug Resistance, Neoplasm - drug effects Drug Resistance, Neoplasm - genetics Female Humans Ovarian Neoplasms - drug therapy Ovarian Neoplasms - genetics Ovarian Neoplasms - metabolism Ovarian Neoplasms - pathology Poly(ADP-ribose) Polymerase Inhibitors - pharmacology Retinoblastoma Binding Proteins - genetics Retinoblastoma Binding Proteins - metabolism SciAdv r-articles Synthetic Lethal Mutations Triple Negative Breast Neoplasms - drug therapy Triple Negative Breast Neoplasms - genetics Triple Negative Breast Neoplasms - metabolism Triple Negative Breast Neoplasms - pathology Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism
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