Apaf1-deficient cortical neurons exhibit defects in axonal outgrowth

The establishment of neuronal polarity and axonal outgrowth are key processes affecting neuronal migration and synapse formation, their impairment likely leading to cognitive deficits. Here we have found that the apoptotic protease activating factor 1 (Apaf1), apart from its canonical role in apopto...

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Veröffentlicht in:	Cellular and molecular life sciences : CMLS 2015-11, Vol.72 (21), p.4173-4191
Hauptverfasser:	De Zio, Daniela, Molinari, Francesca, Rizza, Salvatore, Gatta, Lucia, Ciotti, Maria Teresa, Salvatore, Anna Maria, Mathiassen, Søs Grønbæk, Cwetsch, Andrzej W., Filomeni, Giuseppe, Rosano, Giuseppe, Ferraro, Elisabetta
Format:	Artikel
Sprache:	eng
Schlagworte:	AMP-Activated Protein Kinases - genetics AMP-Activated Protein Kinases - metabolism Animals Apoptotic Protease-Activating Factor 1 - genetics Apoptotic Protease-Activating Factor 1 - metabolism Axons - pathology Axons - physiology Biochemistry Biomedical and Life Sciences Biomedicine Cell adhesion & migration Cell Biology Cell Differentiation Centrosome - metabolism Cerebral Cortex - embryology Cerebral Cortex - pathology Disks Large Homolog 4 Protein Gene Expression Regulation, Developmental Golgi Apparatus - metabolism Guanylate Kinases - genetics Guanylate Kinases - metabolism Life Sciences Membrane Proteins - genetics Membrane Proteins - metabolism Mice, Knockout Microtubule-Associated Proteins - metabolism Mitochondria Mitochondria - genetics Mitochondria - metabolism Neurons Neurons - cytology Neurons - pathology Neurons - physiology Neurophysiology Protein Serine-Threonine Kinases - genetics Protein Serine-Threonine Kinases - metabolism Research Article
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