The interrelationship between bone and fat: from cellular see-saw to endocrine reciprocity
The number of mature osteoblasts and marrow adipocytes in bone is influenced by the differentiation of the common mesenchymal progenitor cell towards one phenotype and away from the other. Consequently, factors which promote adipogenesis not only lead to fatty marrow but also inhibit osteoblastogene...
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| Veröffentlicht in: | Cellular and molecular life sciences : CMLS 2013-07, Vol.70 (13), p.2331-2349 |
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| creator | Sadie-Van Gijsen, H. Crowther, N. J. Hough, F. S. Ferris, W. F. |
| description | The number of mature osteoblasts and marrow adipocytes in bone is influenced by the differentiation of the common mesenchymal progenitor cell towards one phenotype and away from the other. Consequently, factors which promote adipogenesis not only lead to fatty marrow but also inhibit osteoblastogenesis, resulting in decreased osteoblast numbers, diminished bone formation and, potentially, inadequate bone mass and osteoporosis. In addition to osteoblast and bone adipocyte numbers being influenced by this skewing of progenitor cell differentiation towards one phenotype, mature osteoblasts and adipocytes secrete factors which may evoke changes in the cell fate and function of each other. This review examines the endogenous factors, such as PPAR-γ2, Wnt, IGF-1, GH, FGF-2, oestrogen, the GP130 signalling cytokines, vitamin D and glucocorticoids, which regulate the selection between osteoblastogenesis and adipogenesis and the interrelationship between fat and bone. The role of adipokines on bone, such as adiponectin and leptin, as well as adipose-derived oestrogen, is reviewed and the role of bone as an energy regulating endocrine organ is discussed. |
| doi_str_mv | 10.1007/s00018-012-1211-2 |
| format | Article |
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This review examines the endogenous factors, such as PPAR-γ2, Wnt, IGF-1, GH, FGF-2, oestrogen, the GP130 signalling cytokines, vitamin D and glucocorticoids, which regulate the selection between osteoblastogenesis and adipogenesis and the interrelationship between fat and bone. The role of adipokines on bone, such as adiponectin and leptin, as well as adipose-derived oestrogen, is reviewed and the role of bone as an energy regulating endocrine organ is discussed.</description><identifier>ISSN: 1420-682X</identifier><identifier>EISSN: 1420-9071</identifier><identifier>DOI: 10.1007/s00018-012-1211-2</identifier><identifier>PMID: 23178849</identifier><language>eng</language><publisher>Basel: SP Birkhäuser Verlag Basel</publisher><subject>Adipocytes ; Adipocytes - cytology ; Adipogenesis ; Adipokines - physiology ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Body fat ; Bone marrow ; Bone Marrow Cells - cytology ; Cell Biology ; Cell Differentiation ; Cellular biology ; Cytokine Receptor gp130 - physiology ; Endocrine system ; Endocrine System - physiology ; Estrogens - physiology ; Fibroblast Growth Factor 2 - physiology ; Glucocorticoids - physiology ; Growth Hormone - physiology ; Humans ; Insulin-Like Growth Factor I - physiology ; Life Sciences ; Mesenchymal Stem Cells - cytology ; Osteoblasts - cytology ; Osteoporosis ; PPAR gamma - physiology ; Review ; Signal Transduction ; Vitamin D ; Vitamin D - physiology ; Wnt Proteins - physiology</subject><ispartof>Cellular and molecular life sciences : CMLS, 2013-07, Vol.70 (13), p.2331-2349</ispartof><rights>Springer Basel 2012</rights><rights>Springer Basel 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c570t-f1f3978a98250c33bbc446bc5ecaaecbe26f75c763705278d4d2768eae12f3023</citedby><cites>FETCH-LOGICAL-c570t-f1f3978a98250c33bbc446bc5ecaaecbe26f75c763705278d4d2768eae12f3023</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11113730/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11113730/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,41488,42557,51319,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23178849$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sadie-Van Gijsen, H.</creatorcontrib><creatorcontrib>Crowther, N. 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In addition to osteoblast and bone adipocyte numbers being influenced by this skewing of progenitor cell differentiation towards one phenotype, mature osteoblasts and adipocytes secrete factors which may evoke changes in the cell fate and function of each other. This review examines the endogenous factors, such as PPAR-γ2, Wnt, IGF-1, GH, FGF-2, oestrogen, the GP130 signalling cytokines, vitamin D and glucocorticoids, which regulate the selection between osteoblastogenesis and adipogenesis and the interrelationship between fat and bone. 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In addition to osteoblast and bone adipocyte numbers being influenced by this skewing of progenitor cell differentiation towards one phenotype, mature osteoblasts and adipocytes secrete factors which may evoke changes in the cell fate and function of each other. This review examines the endogenous factors, such as PPAR-γ2, Wnt, IGF-1, GH, FGF-2, oestrogen, the GP130 signalling cytokines, vitamin D and glucocorticoids, which regulate the selection between osteoblastogenesis and adipogenesis and the interrelationship between fat and bone. The role of adipokines on bone, such as adiponectin and leptin, as well as adipose-derived oestrogen, is reviewed and the role of bone as an energy regulating endocrine organ is discussed.</abstract><cop>Basel</cop><pub>SP Birkhäuser Verlag Basel</pub><pmid>23178849</pmid><doi>10.1007/s00018-012-1211-2</doi><tpages>19</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adipocytes Adipocytes - cytology Adipogenesis Adipokines - physiology Biochemistry Biomedical and Life Sciences Biomedicine Body fat Bone marrow Bone Marrow Cells - cytology Cell Biology Cell Differentiation Cellular biology Cytokine Receptor gp130 - physiology Endocrine system Endocrine System - physiology Estrogens - physiology Fibroblast Growth Factor 2 - physiology Glucocorticoids - physiology Growth Hormone - physiology Humans Insulin-Like Growth Factor I - physiology Life Sciences Mesenchymal Stem Cells - cytology Osteoblasts - cytology Osteoporosis PPAR gamma - physiology Review Signal Transduction Vitamin D Vitamin D - physiology Wnt Proteins - physiology |
| title | The interrelationship between bone and fat: from cellular see-saw to endocrine reciprocity |
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