expansion of GPCR transactivation-dependent signalling to include serine/threonine kinase receptors represents a new cell signalling frontier

G protein-coupled receptor (GPCR) signalling is mediated through transactivation-independent signalling pathways or the transactivation of protein tyrosine kinase receptors and the recently reported activation of the serine/threonine kinase receptors, most notably the transforming growth factor-β re...

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Veröffentlicht in:Cellular and molecular life sciences : CMLS 2015-02, Vol.72 (4), p.799-808
Hauptverfasser: Kamato, Danielle, Rostam, Muhamad Ashraf, Bernard, Rebekah, Piva, Terrence J, Mantri, Nitin, Guidone, Daniel, Zheng, Wenhua, Osman, Narin, Little, Peter J
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container_title Cellular and molecular life sciences : CMLS
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creator Kamato, Danielle
Rostam, Muhamad Ashraf
Bernard, Rebekah
Piva, Terrence J
Mantri, Nitin
Guidone, Daniel
Zheng, Wenhua
Osman, Narin
Little, Peter J
description G protein-coupled receptor (GPCR) signalling is mediated through transactivation-independent signalling pathways or the transactivation of protein tyrosine kinase receptors and the recently reported activation of the serine/threonine kinase receptors, most notably the transforming growth factor-β receptor family. Since the original observation of GPCR transactivation of protein tyrosine kinase receptors, there has been considerable work on the mechanism of transactivation and several pathways are prominent. These pathways include the “triple membrane bypass” pathway and the generation of reactive oxygen species. The recent recognition of GPCR transactivation of serine/threonine kinase receptors enormously broadens the GPCR signalling paradigm. It may be predicted that the transactivation of serine/threonine kinase receptors would have mechanistic similarities with transactivation of tyrosine kinase pathways; however, initial studies suggest that these two transactivation pathways are mechanistically distinct. Important questions are the relative importance of tyrosine and serine/threonine transactivation pathways, the contribution of transactivation to overall GPCR signalling, mechanisms of transactivation and the range of cell types in which this phenomenon occurs. The ultimate significance of transactivation-dependent signalling remains to be defined but it appears to be prominent and if so will represent a new cell signalling frontier.
doi_str_mv 10.1007/s00018-014-1775-0
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subjects Animals
Biochemistry
Biomedical and Life Sciences
Biomedicine
Cell Biology
Cellular biology
G-protein coupled receptors
Humans
Kinases
Life Sciences
protein-serine-threonine kinases
Proteins
reactive oxygen species
Receptor Protein-Tyrosine Kinases - metabolism
receptors
Receptors, G-Protein-Coupled - genetics
Receptors, G-Protein-Coupled - metabolism
Review
rho-Associated Kinases - metabolism
serine
Signal Transduction
threonine
Transcriptional Activation
tyrosine
title expansion of GPCR transactivation-dependent signalling to include serine/threonine kinase receptors represents a new cell signalling frontier
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