expansion of GPCR transactivation-dependent signalling to include serine/threonine kinase receptors represents a new cell signalling frontier
G protein-coupled receptor (GPCR) signalling is mediated through transactivation-independent signalling pathways or the transactivation of protein tyrosine kinase receptors and the recently reported activation of the serine/threonine kinase receptors, most notably the transforming growth factor-β re...
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creator | Kamato, Danielle Rostam, Muhamad Ashraf Bernard, Rebekah Piva, Terrence J Mantri, Nitin Guidone, Daniel Zheng, Wenhua Osman, Narin Little, Peter J |
description | G protein-coupled receptor (GPCR) signalling is mediated through transactivation-independent signalling pathways or the transactivation of protein tyrosine kinase receptors and the recently reported activation of the serine/threonine kinase receptors, most notably the transforming growth factor-β receptor family. Since the original observation of GPCR transactivation of protein tyrosine kinase receptors, there has been considerable work on the mechanism of transactivation and several pathways are prominent. These pathways include the “triple membrane bypass” pathway and the generation of reactive oxygen species. The recent recognition of GPCR transactivation of serine/threonine kinase receptors enormously broadens the GPCR signalling paradigm. It may be predicted that the transactivation of serine/threonine kinase receptors would have mechanistic similarities with transactivation of tyrosine kinase pathways; however, initial studies suggest that these two transactivation pathways are mechanistically distinct. Important questions are the relative importance of tyrosine and serine/threonine transactivation pathways, the contribution of transactivation to overall GPCR signalling, mechanisms of transactivation and the range of cell types in which this phenomenon occurs. The ultimate significance of transactivation-dependent signalling remains to be defined but it appears to be prominent and if so will represent a new cell signalling frontier. |
doi_str_mv | 10.1007/s00018-014-1775-0 |
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Since the original observation of GPCR transactivation of protein tyrosine kinase receptors, there has been considerable work on the mechanism of transactivation and several pathways are prominent. These pathways include the “triple membrane bypass” pathway and the generation of reactive oxygen species. The recent recognition of GPCR transactivation of serine/threonine kinase receptors enormously broadens the GPCR signalling paradigm. It may be predicted that the transactivation of serine/threonine kinase receptors would have mechanistic similarities with transactivation of tyrosine kinase pathways; however, initial studies suggest that these two transactivation pathways are mechanistically distinct. Important questions are the relative importance of tyrosine and serine/threonine transactivation pathways, the contribution of transactivation to overall GPCR signalling, mechanisms of transactivation and the range of cell types in which this phenomenon occurs. The ultimate significance of transactivation-dependent signalling remains to be defined but it appears to be prominent and if so will represent a new cell signalling frontier.</description><identifier>ISSN: 1420-682X</identifier><identifier>EISSN: 1420-9071</identifier><identifier>DOI: 10.1007/s00018-014-1775-0</identifier><identifier>PMID: 25384733</identifier><language>eng</language><publisher>Basel: Springer-Verlag</publisher><subject>Animals ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Cell Biology ; Cellular biology ; G-protein coupled receptors ; Humans ; Kinases ; Life Sciences ; protein-serine-threonine kinases ; Proteins ; reactive oxygen species ; Receptor Protein-Tyrosine Kinases - metabolism ; receptors ; Receptors, G-Protein-Coupled - genetics ; Receptors, G-Protein-Coupled - metabolism ; Review ; rho-Associated Kinases - metabolism ; serine ; Signal Transduction ; threonine ; Transcriptional Activation ; tyrosine</subject><ispartof>Cellular and molecular life sciences : CMLS, 2015-02, Vol.72 (4), p.799-808</ispartof><rights>Springer Basel 2014</rights><rights>Springer Basel 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c522t-9b1871c10066bde873d0a88856e77160f1d8e855246e78fe0a55656c81030da13</citedby><cites>FETCH-LOGICAL-c522t-9b1871c10066bde873d0a88856e77160f1d8e855246e78fe0a55656c81030da13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11113717/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11113717/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,41487,42556,51318,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25384733$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kamato, Danielle</creatorcontrib><creatorcontrib>Rostam, Muhamad Ashraf</creatorcontrib><creatorcontrib>Bernard, Rebekah</creatorcontrib><creatorcontrib>Piva, Terrence J</creatorcontrib><creatorcontrib>Mantri, Nitin</creatorcontrib><creatorcontrib>Guidone, Daniel</creatorcontrib><creatorcontrib>Zheng, Wenhua</creatorcontrib><creatorcontrib>Osman, Narin</creatorcontrib><creatorcontrib>Little, Peter J</creatorcontrib><title>expansion of GPCR transactivation-dependent signalling to include serine/threonine kinase receptors represents a new cell signalling frontier</title><title>Cellular and molecular life sciences : CMLS</title><addtitle>Cell. Mol. Life Sci</addtitle><addtitle>Cell Mol Life Sci</addtitle><description>G protein-coupled receptor (GPCR) signalling is mediated through transactivation-independent signalling pathways or the transactivation of protein tyrosine kinase receptors and the recently reported activation of the serine/threonine kinase receptors, most notably the transforming growth factor-β receptor family. Since the original observation of GPCR transactivation of protein tyrosine kinase receptors, there has been considerable work on the mechanism of transactivation and several pathways are prominent. These pathways include the “triple membrane bypass” pathway and the generation of reactive oxygen species. The recent recognition of GPCR transactivation of serine/threonine kinase receptors enormously broadens the GPCR signalling paradigm. It may be predicted that the transactivation of serine/threonine kinase receptors would have mechanistic similarities with transactivation of tyrosine kinase pathways; however, initial studies suggest that these two transactivation pathways are mechanistically distinct. Important questions are the relative importance of tyrosine and serine/threonine transactivation pathways, the contribution of transactivation to overall GPCR signalling, mechanisms of transactivation and the range of cell types in which this phenomenon occurs. The ultimate significance of transactivation-dependent signalling remains to be defined but it appears to be prominent and if so will represent a new cell signalling frontier.</description><subject>Animals</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell Biology</subject><subject>Cellular biology</subject><subject>G-protein coupled receptors</subject><subject>Humans</subject><subject>Kinases</subject><subject>Life Sciences</subject><subject>protein-serine-threonine kinases</subject><subject>Proteins</subject><subject>reactive oxygen species</subject><subject>Receptor Protein-Tyrosine Kinases - metabolism</subject><subject>receptors</subject><subject>Receptors, G-Protein-Coupled - genetics</subject><subject>Receptors, G-Protein-Coupled - metabolism</subject><subject>Review</subject><subject>rho-Associated Kinases - metabolism</subject><subject>serine</subject><subject>Signal 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Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kamato, Danielle</au><au>Rostam, Muhamad Ashraf</au><au>Bernard, Rebekah</au><au>Piva, Terrence J</au><au>Mantri, Nitin</au><au>Guidone, Daniel</au><au>Zheng, Wenhua</au><au>Osman, Narin</au><au>Little, Peter J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>expansion of GPCR transactivation-dependent signalling to include serine/threonine kinase receptors represents a new cell signalling frontier</atitle><jtitle>Cellular and molecular life sciences : CMLS</jtitle><stitle>Cell. Mol. Life Sci</stitle><addtitle>Cell Mol Life Sci</addtitle><date>2015-02-01</date><risdate>2015</risdate><volume>72</volume><issue>4</issue><spage>799</spage><epage>808</epage><pages>799-808</pages><issn>1420-682X</issn><eissn>1420-9071</eissn><abstract>G protein-coupled receptor (GPCR) signalling is mediated through transactivation-independent signalling pathways or the transactivation of protein tyrosine kinase receptors and the recently reported activation of the serine/threonine kinase receptors, most notably the transforming growth factor-β receptor family. Since the original observation of GPCR transactivation of protein tyrosine kinase receptors, there has been considerable work on the mechanism of transactivation and several pathways are prominent. These pathways include the “triple membrane bypass” pathway and the generation of reactive oxygen species. The recent recognition of GPCR transactivation of serine/threonine kinase receptors enormously broadens the GPCR signalling paradigm. It may be predicted that the transactivation of serine/threonine kinase receptors would have mechanistic similarities with transactivation of tyrosine kinase pathways; however, initial studies suggest that these two transactivation pathways are mechanistically distinct. Important questions are the relative importance of tyrosine and serine/threonine transactivation pathways, the contribution of transactivation to overall GPCR signalling, mechanisms of transactivation and the range of cell types in which this phenomenon occurs. The ultimate significance of transactivation-dependent signalling remains to be defined but it appears to be prominent and if so will represent a new cell signalling frontier.</abstract><cop>Basel</cop><pub>Springer-Verlag</pub><pmid>25384733</pmid><doi>10.1007/s00018-014-1775-0</doi><tpages>10</tpages></addata></record> |
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subjects | Animals Biochemistry Biomedical and Life Sciences Biomedicine Cell Biology Cellular biology G-protein coupled receptors Humans Kinases Life Sciences protein-serine-threonine kinases Proteins reactive oxygen species Receptor Protein-Tyrosine Kinases - metabolism receptors Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism Review rho-Associated Kinases - metabolism serine Signal Transduction threonine Transcriptional Activation tyrosine |
title | expansion of GPCR transactivation-dependent signalling to include serine/threonine kinase receptors represents a new cell signalling frontier |
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