The effect of five proteins on stem cells used for osteoblast differentiation and proliferation: a current review of the literature
Bone-tissue engineering is a therapeutic target in the field of dental implant and orthopedic surgery. It is therefore essential to find a microenvironment that enhances the growth and differentiation of osteoblasts both from mesenchymal stem cells (MSCs) and those derived from dental pulp. The aim...
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| Veröffentlicht in: | Cellular and molecular life sciences : CMLS 2014-01, Vol.71 (1), p.113-142 |
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| creator | Chatakun, P. Núñez-Toldrà, R. Díaz López, E. J. Gil-Recio, C. Martínez-Sarrà, E. Hernández-Alfaro, F. Ferrés-Padró, E. Giner-Tarrida, L. Atari, M. |
| description | Bone-tissue engineering is a therapeutic target in the field of dental implant and orthopedic surgery. It is therefore essential to find a microenvironment that enhances the growth and differentiation of osteoblasts both from mesenchymal stem cells (MSCs) and those derived from dental pulp. The aim of this review is to determine the relationship among the proteins fibronectin (FN), osteopontin (OPN), tenascin (TN), bone sialoprotein (BSP), and bone morphogenetic protein (BMP2) and their ability to coat different types of biomaterials and surfaces to enhance osteoblast differentiation. Pre-treatment of biomaterials with FN during the initial phase of osteogenic differentiation on all types of surfaces, including slotted titanium and polymers, provides an ideal microenvironment that enhances adhesion, morphology, and proliferation of pluripotent and multipotent cells. Likewise, in the second stage of differentiation, surface coating with BMP2 decreases the diameter and the pore size of the scaffold, causing better adhesion and reduced proliferation of BMP-MSCs. Coating oligomerization surfaces with OPN and BSP promotes cell adhesion, but it is clear that the polymeric coating material BSP alone is insufficient to induce priming of MSCs and functional osteoblastic differentiation in vivo. Finally, TN is involved in mineralization and can accelerate new bone formation in a multicellular environment but has no effect on the initial stage of osteogenesis. |
| doi_str_mv | 10.1007/s00018-013-1326-0 |
| format | Article |
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J. ; Gil-Recio, C. ; Martínez-Sarrà, E. ; Hernández-Alfaro, F. ; Ferrés-Padró, E. ; Giner-Tarrida, L. ; Atari, M.</creator><creatorcontrib>Chatakun, P. ; Núñez-Toldrà, R. ; Díaz López, E. J. ; Gil-Recio, C. ; Martínez-Sarrà, E. ; Hernández-Alfaro, F. ; Ferrés-Padró, E. ; Giner-Tarrida, L. ; Atari, M.</creatorcontrib><description>Bone-tissue engineering is a therapeutic target in the field of dental implant and orthopedic surgery. It is therefore essential to find a microenvironment that enhances the growth and differentiation of osteoblasts both from mesenchymal stem cells (MSCs) and those derived from dental pulp. The aim of this review is to determine the relationship among the proteins fibronectin (FN), osteopontin (OPN), tenascin (TN), bone sialoprotein (BSP), and bone morphogenetic protein (BMP2) and their ability to coat different types of biomaterials and surfaces to enhance osteoblast differentiation. Pre-treatment of biomaterials with FN during the initial phase of osteogenic differentiation on all types of surfaces, including slotted titanium and polymers, provides an ideal microenvironment that enhances adhesion, morphology, and proliferation of pluripotent and multipotent cells. Likewise, in the second stage of differentiation, surface coating with BMP2 decreases the diameter and the pore size of the scaffold, causing better adhesion and reduced proliferation of BMP-MSCs. Coating oligomerization surfaces with OPN and BSP promotes cell adhesion, but it is clear that the polymeric coating material BSP alone is insufficient to induce priming of MSCs and functional osteoblastic differentiation in vivo. Finally, TN is involved in mineralization and can accelerate new bone formation in a multicellular environment but has no effect on the initial stage of osteogenesis.</description><identifier>ISSN: 1420-682X</identifier><identifier>EISSN: 1420-9071</identifier><identifier>DOI: 10.1007/s00018-013-1326-0</identifier><identifier>PMID: 23568025</identifier><language>eng</language><publisher>Basel: Springer Basel</publisher><subject>Adhesion ; Biochemistry ; Biomaterials ; Biomedical and Life Sciences ; Biomedicine ; Bone Morphogenetic Protein 2 - metabolism ; Cell Biology ; Cell Differentiation ; Dental Pulp - cytology ; Fibronectins - metabolism ; Gene expression ; Humans ; Integrin-Binding Sialoprotein - metabolism ; Life Sciences ; Mesenchymal Stem Cells - cytology ; Mesenchymal Stem Cells - metabolism ; Mineralization ; Osteoblasts - cytology ; Osteoblasts - metabolism ; Osteogenesis ; Osteopontin - metabolism ; Polymers ; Pore size ; Proteins ; Review ; Signal transduction ; Stem cells ; Tenascin - metabolism ; Tissue engineering</subject><ispartof>Cellular and molecular life sciences : CMLS, 2014-01, Vol.71 (1), p.113-142</ispartof><rights>Springer Basel 2013</rights><rights>Springer Basel 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c527t-6e513a41e0ab2a5838c2d01b389c71d3b1b548d1293cbec1e3b255f39f6cd62c3</citedby><cites>FETCH-LOGICAL-c527t-6e513a41e0ab2a5838c2d01b389c71d3b1b548d1293cbec1e3b255f39f6cd62c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11113514/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11113514/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,41488,42557,51319,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23568025$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chatakun, P.</creatorcontrib><creatorcontrib>Núñez-Toldrà, R.</creatorcontrib><creatorcontrib>Díaz López, E. 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The aim of this review is to determine the relationship among the proteins fibronectin (FN), osteopontin (OPN), tenascin (TN), bone sialoprotein (BSP), and bone morphogenetic protein (BMP2) and their ability to coat different types of biomaterials and surfaces to enhance osteoblast differentiation. Pre-treatment of biomaterials with FN during the initial phase of osteogenic differentiation on all types of surfaces, including slotted titanium and polymers, provides an ideal microenvironment that enhances adhesion, morphology, and proliferation of pluripotent and multipotent cells. Likewise, in the second stage of differentiation, surface coating with BMP2 decreases the diameter and the pore size of the scaffold, causing better adhesion and reduced proliferation of BMP-MSCs. Coating oligomerization surfaces with OPN and BSP promotes cell adhesion, but it is clear that the polymeric coating material BSP alone is insufficient to induce priming of MSCs and functional osteoblastic differentiation in vivo. 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The aim of this review is to determine the relationship among the proteins fibronectin (FN), osteopontin (OPN), tenascin (TN), bone sialoprotein (BSP), and bone morphogenetic protein (BMP2) and their ability to coat different types of biomaterials and surfaces to enhance osteoblast differentiation. Pre-treatment of biomaterials with FN during the initial phase of osteogenic differentiation on all types of surfaces, including slotted titanium and polymers, provides an ideal microenvironment that enhances adhesion, morphology, and proliferation of pluripotent and multipotent cells. Likewise, in the second stage of differentiation, surface coating with BMP2 decreases the diameter and the pore size of the scaffold, causing better adhesion and reduced proliferation of BMP-MSCs. 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| subjects | Adhesion Biochemistry Biomaterials Biomedical and Life Sciences Biomedicine Bone Morphogenetic Protein 2 - metabolism Cell Biology Cell Differentiation Dental Pulp - cytology Fibronectins - metabolism Gene expression Humans Integrin-Binding Sialoprotein - metabolism Life Sciences Mesenchymal Stem Cells - cytology Mesenchymal Stem Cells - metabolism Mineralization Osteoblasts - cytology Osteoblasts - metabolism Osteogenesis Osteopontin - metabolism Polymers Pore size Proteins Review Signal transduction Stem cells Tenascin - metabolism Tissue engineering |
| title | The effect of five proteins on stem cells used for osteoblast differentiation and proliferation: a current review of the literature |
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