Innate lymphoid cells in intestinal immunity and inflammation
Innate lymphoid cells (ILCs) are a new and distinct family of innate immune cells that play an important role in immunity and inflammation. In this review, we focus on the role of ILCs in mucosal tissues, especially in the gut, in health and disease. ILCs support intestinal homeostasis by protecting...
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| Veröffentlicht in: | Cellular and molecular life sciences : CMLS 2016-01, Vol.73 (2), p.237-252 |
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| description | Innate lymphoid cells (ILCs) are a new and distinct family of innate immune cells that play an important role in immunity and inflammation. In this review, we focus on the role of ILCs in mucosal tissues, especially in the gut, in health and disease. ILCs support intestinal homeostasis by protecting the intestine from pathogens, contributing to the development of gut lymphoid tissue, and helping to repair injuries. By cooperating with epithelial cells and other innate and adaptive immune cells, ILCs participate in the control of pathogens and tolerance of commensal bacteria. The development and maintenance of ILCs are influenced by nutrients and metabolites sourced from diet and/or gut bacteria. ILCs have been shown to be involved in host metabolism and to participate in various diseases of the intestine including infectious and chronic inflammatory diseases, and cancer. Thus, the elucidation of ILC biology provides an exciting potential for development of novel therapeutic means to modulate immune responses in various disease settings. |
| doi_str_mv | 10.1007/s00018-015-2055-3 |
| format | Article |
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In this review, we focus on the role of ILCs in mucosal tissues, especially in the gut, in health and disease. ILCs support intestinal homeostasis by protecting the intestine from pathogens, contributing to the development of gut lymphoid tissue, and helping to repair injuries. By cooperating with epithelial cells and other innate and adaptive immune cells, ILCs participate in the control of pathogens and tolerance of commensal bacteria. The development and maintenance of ILCs are influenced by nutrients and metabolites sourced from diet and/or gut bacteria. ILCs have been shown to be involved in host metabolism and to participate in various diseases of the intestine including infectious and chronic inflammatory diseases, and cancer. Thus, the elucidation of ILC biology provides an exciting potential for development of novel therapeutic means to modulate immune responses in various disease settings.</description><identifier>ISSN: 1420-682X</identifier><identifier>EISSN: 1420-9071</identifier><identifier>DOI: 10.1007/s00018-015-2055-3</identifier><identifier>PMID: 26459449</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Animals ; bacteria ; Bacteria - immunology ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Cell Biology ; Diet ; epithelial cells ; Gastrointestinal Microbiome ; Homeostasis ; Humans ; immune response ; Immunity (Disease) ; Immunity, Innate ; Inflammation ; Inflammation - immunology ; Inflammation - metabolism ; Inflammation - microbiology ; intestinal microorganisms ; Intestinal Mucosa - metabolism ; intestines ; Intestines - cytology ; Intestines - immunology ; Intestines - microbiology ; Life Sciences ; Lymphocytes - immunology ; Lymphocytes - metabolism ; Lymphocytes - microbiology ; Metabolism ; Metabolites ; nutrients ; Nutrition ; Pathogens ; Review ; tissues</subject><ispartof>Cellular and molecular life sciences : CMLS, 2016-01, Vol.73 (2), p.237-252</ispartof><rights>Springer Basel 2015</rights><rights>Springer International Publishing 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c551t-42d6e70a2f62adc78f52a4bc037561890c89032cc36f97f31d68417de94d18163</citedby><cites>FETCH-LOGICAL-c551t-42d6e70a2f62adc78f52a4bc037561890c89032cc36f97f31d68417de94d18163</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11108440/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11108440/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,41464,42533,51294,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26459449$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bostick, John W</creatorcontrib><creatorcontrib>Zhou, Liang</creatorcontrib><title>Innate lymphoid cells in intestinal immunity and inflammation</title><title>Cellular and molecular life sciences : CMLS</title><addtitle>Cell. Mol. Life Sci</addtitle><addtitle>Cell Mol Life Sci</addtitle><description>Innate lymphoid cells (ILCs) are a new and distinct family of innate immune cells that play an important role in immunity and inflammation. In this review, we focus on the role of ILCs in mucosal tissues, especially in the gut, in health and disease. ILCs support intestinal homeostasis by protecting the intestine from pathogens, contributing to the development of gut lymphoid tissue, and helping to repair injuries. By cooperating with epithelial cells and other innate and adaptive immune cells, ILCs participate in the control of pathogens and tolerance of commensal bacteria. The development and maintenance of ILCs are influenced by nutrients and metabolites sourced from diet and/or gut bacteria. ILCs have been shown to be involved in host metabolism and to participate in various diseases of the intestine including infectious and chronic inflammatory diseases, and cancer. Thus, the elucidation of ILC biology provides an exciting potential for development of novel therapeutic means to modulate immune responses in various disease settings.</description><subject>Animals</subject><subject>bacteria</subject><subject>Bacteria - immunology</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell Biology</subject><subject>Diet</subject><subject>epithelial cells</subject><subject>Gastrointestinal Microbiome</subject><subject>Homeostasis</subject><subject>Humans</subject><subject>immune response</subject><subject>Immunity (Disease)</subject><subject>Immunity, Innate</subject><subject>Inflammation</subject><subject>Inflammation - immunology</subject><subject>Inflammation - metabolism</subject><subject>Inflammation - microbiology</subject><subject>intestinal microorganisms</subject><subject>Intestinal Mucosa - metabolism</subject><subject>intestines</subject><subject>Intestines - cytology</subject><subject>Intestines - immunology</subject><subject>Intestines - microbiology</subject><subject>Life Sciences</subject><subject>Lymphocytes - immunology</subject><subject>Lymphocytes - metabolism</subject><subject>Lymphocytes - microbiology</subject><subject>Metabolism</subject><subject>Metabolites</subject><subject>nutrients</subject><subject>Nutrition</subject><subject>Pathogens</subject><subject>Review</subject><subject>tissues</subject><issn>1420-682X</issn><issn>1420-9071</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkU9rFjEQxhex2Fr9AF50wUsva2fyPwcpUqoWCj1owVtIs9m3KbvZ12RXeL-9Wfa1VA9SSMiQ-c2TmTxV9QbhAwLI0wwAqBpA3hDgvKHPqiNkBBoNEp_vY6HIj8PqZc73BeaKiBfVIRGMa8b0UfXxMkY7-brfDdu7MbS1832f6xDLmnyeQrR9HYZhjmHa1Ta25b7r7TDYKYzxVXXQ2T771_vzuLr5fPH9_Gtzdf3l8vzTVeM4x6lhpBVegiWdILZ1UnWcWHbrgEouUGlwZVPiHBWdlh3FViiGsvWatahQ0OPqbNXdzreDb52PU7K92aYw2LQzow3m70wMd2Yz_jKICIoxKAone4U0_pzLYGYIeZnVRj_O2aCUVFGmiH4CKkApAM0K-v4f9H6cU_myheKcMCr40j2ulEtjzsl3D40jmMVIsxppij9mMdLQUvP28cQPFX-cKwBZgVxScePTo6f_o_puLersaOwmhWxuvhFAUUiptZb0NxN0sKM</recordid><startdate>20160101</startdate><enddate>20160101</enddate><creator>Bostick, John W</creator><creator>Zhou, Liang</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SS</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>P64</scope><scope>PATMY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160101</creationdate><title>Innate lymphoid cells in intestinal immunity and inflammation</title><author>Bostick, John W ; Zhou, Liang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c551t-42d6e70a2f62adc78f52a4bc037561890c89032cc36f97f31d68417de94d18163</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>bacteria</topic><topic>Bacteria - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cellular and molecular life sciences : CMLS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bostick, John W</au><au>Zhou, Liang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Innate lymphoid cells in intestinal immunity and inflammation</atitle><jtitle>Cellular and molecular life sciences : CMLS</jtitle><stitle>Cell. Mol. Life Sci</stitle><addtitle>Cell Mol Life Sci</addtitle><date>2016-01-01</date><risdate>2016</risdate><volume>73</volume><issue>2</issue><spage>237</spage><epage>252</epage><pages>237-252</pages><issn>1420-682X</issn><eissn>1420-9071</eissn><abstract>Innate lymphoid cells (ILCs) are a new and distinct family of innate immune cells that play an important role in immunity and inflammation. In this review, we focus on the role of ILCs in mucosal tissues, especially in the gut, in health and disease. ILCs support intestinal homeostasis by protecting the intestine from pathogens, contributing to the development of gut lymphoid tissue, and helping to repair injuries. By cooperating with epithelial cells and other innate and adaptive immune cells, ILCs participate in the control of pathogens and tolerance of commensal bacteria. The development and maintenance of ILCs are influenced by nutrients and metabolites sourced from diet and/or gut bacteria. ILCs have been shown to be involved in host metabolism and to participate in various diseases of the intestine including infectious and chronic inflammatory diseases, and cancer. Thus, the elucidation of ILC biology provides an exciting potential for development of novel therapeutic means to modulate immune responses in various disease settings.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>26459449</pmid><doi>10.1007/s00018-015-2055-3</doi><tpages>16</tpages></addata></record> |
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| subjects | Animals bacteria Bacteria - immunology Biochemistry Biomedical and Life Sciences Biomedicine Cell Biology Diet epithelial cells Gastrointestinal Microbiome Homeostasis Humans immune response Immunity (Disease) Immunity, Innate Inflammation Inflammation - immunology Inflammation - metabolism Inflammation - microbiology intestinal microorganisms Intestinal Mucosa - metabolism intestines Intestines - cytology Intestines - immunology Intestines - microbiology Life Sciences Lymphocytes - immunology Lymphocytes - metabolism Lymphocytes - microbiology Metabolism Metabolites nutrients Nutrition Pathogens Review tissues |
| title | Innate lymphoid cells in intestinal immunity and inflammation |
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