Coordinated shift of olfactory amino acid responses and V2R expression to an amphibian water nose during metamorphosis
All olfactory receptors identified in teleost fish are expressed in a single sensory surface, whereas mammalian olfactory receptor gene families segregate into different olfactory organs, chief among them the main olfactory epithelium expressing ORs and TAARs, and the vomeronasal organ expressing V1...
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| Veröffentlicht in: | Cellular and molecular life sciences : CMLS 2017-05, Vol.74 (9), p.1711-1719 |
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| creator | Syed, Adnan S. Sansone, Alfredo Hassenklöver, Thomas Manzini, Ivan Korsching, Sigrun I. |
| description | All olfactory receptors identified in teleost fish are expressed in a single sensory surface, whereas mammalian olfactory receptor gene families segregate into different olfactory organs, chief among them the main olfactory epithelium expressing ORs and TAARs, and the vomeronasal organ expressing V1Rs and V2Rs. A transitional stage is embodied by amphibians, with their vomeronasal organ expressing more ‘modern’, later diverging V2Rs, whereas more ‘ancient’, earlier diverging V2Rs are expressed in the main olfactory epithelium. During metamorphosis, the main olfactory epithelium of
Xenopus
tadpoles transforms into an air-filled cavity (principal cavity, air nose), whereas a newly formed cavity (middle cavity) takes over the function of a water nose. We report here that larval expression of ancient V2Rs is gradually lost from the main olfactory epithelium as it transforms into the air nose. Concomitantly, ancient
v2r
gene expression begins to appear in the basal layers of the newly forming water nose. We observe the same transition for responses to amino acid odorants, consistent with the hypothesis that amino acid responses may be mediated by V2R receptors. |
| doi_str_mv | 10.1007/s00018-016-2437-1 |
| format | Article |
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Xenopus
tadpoles transforms into an air-filled cavity (principal cavity, air nose), whereas a newly formed cavity (middle cavity) takes over the function of a water nose. We report here that larval expression of ancient V2Rs is gradually lost from the main olfactory epithelium as it transforms into the air nose. Concomitantly, ancient
v2r
gene expression begins to appear in the basal layers of the newly forming water nose. We observe the same transition for responses to amino acid odorants, consistent with the hypothesis that amino acid responses may be mediated by V2R receptors.</description><identifier>ISSN: 1420-682X</identifier><identifier>EISSN: 1420-9071</identifier><identifier>DOI: 10.1007/s00018-016-2437-1</identifier><identifier>PMID: 27990576</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Amino acids ; Amino Acids - metabolism ; Amphibians ; Animals ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Cell Biology ; Chemosensory perception ; Female ; Fish ; Gene Expression Regulation, Developmental ; Genes ; Larva - metabolism ; Life Sciences ; Male ; Metamorphism ; Metamorphosis ; Metamorphosis, Biological - genetics ; Nasal Mucosa - metabolism ; Olfactory Mucosa - metabolism ; Olfactory Receptor Neurons - metabolism ; Original ; Original Article ; Receptors, Odorant - metabolism ; Signal Transduction ; Smell ; Teleostei ; Vomeronasal Organ - metabolism ; Water - metabolism ; Xenopus ; Xenopus laevis - metabolism</subject><ispartof>Cellular and molecular life sciences : CMLS, 2017-05, Vol.74 (9), p.1711-1719</ispartof><rights>Springer International Publishing 2016</rights><rights>Cellular and Molecular Life Sciences is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c570t-31d14baa8697aeec02525918cb7f6727357bca2a81f91235799e92b2801b3bf83</citedby><cites>FETCH-LOGICAL-c570t-31d14baa8697aeec02525918cb7f6727357bca2a81f91235799e92b2801b3bf83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11107701/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11107701/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,41464,42533,51294,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27990576$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Syed, Adnan S.</creatorcontrib><creatorcontrib>Sansone, Alfredo</creatorcontrib><creatorcontrib>Hassenklöver, Thomas</creatorcontrib><creatorcontrib>Manzini, Ivan</creatorcontrib><creatorcontrib>Korsching, Sigrun I.</creatorcontrib><title>Coordinated shift of olfactory amino acid responses and V2R expression to an amphibian water nose during metamorphosis</title><title>Cellular and molecular life sciences : CMLS</title><addtitle>Cell. Mol. Life Sci</addtitle><addtitle>Cell Mol Life Sci</addtitle><description>All olfactory receptors identified in teleost fish are expressed in a single sensory surface, whereas mammalian olfactory receptor gene families segregate into different olfactory organs, chief among them the main olfactory epithelium expressing ORs and TAARs, and the vomeronasal organ expressing V1Rs and V2Rs. A transitional stage is embodied by amphibians, with their vomeronasal organ expressing more ‘modern’, later diverging V2Rs, whereas more ‘ancient’, earlier diverging V2Rs are expressed in the main olfactory epithelium. During metamorphosis, the main olfactory epithelium of
Xenopus
tadpoles transforms into an air-filled cavity (principal cavity, air nose), whereas a newly formed cavity (middle cavity) takes over the function of a water nose. We report here that larval expression of ancient V2Rs is gradually lost from the main olfactory epithelium as it transforms into the air nose. Concomitantly, ancient
v2r
gene expression begins to appear in the basal layers of the newly forming water nose. We observe the same transition for responses to amino acid odorants, consistent with the hypothesis that amino acid responses may be mediated by V2R receptors.</description><subject>Amino acids</subject><subject>Amino Acids - metabolism</subject><subject>Amphibians</subject><subject>Animals</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell Biology</subject><subject>Chemosensory perception</subject><subject>Female</subject><subject>Fish</subject><subject>Gene Expression Regulation, Developmental</subject><subject>Genes</subject><subject>Larva - metabolism</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Metamorphism</subject><subject>Metamorphosis</subject><subject>Metamorphosis, Biological - genetics</subject><subject>Nasal Mucosa - metabolism</subject><subject>Olfactory Mucosa - metabolism</subject><subject>Olfactory Receptor Neurons - metabolism</subject><subject>Original</subject><subject>Original Article</subject><subject>Receptors, Odorant - metabolism</subject><subject>Signal Transduction</subject><subject>Smell</subject><subject>Teleostei</subject><subject>Vomeronasal Organ - metabolism</subject><subject>Water - metabolism</subject><subject>Xenopus</subject><subject>Xenopus laevis - metabolism</subject><issn>1420-682X</issn><issn>1420-9071</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkl1rFTEQhoNYbK3-AG8k4I03azPZk01yJXKoH1AQShXvQjab7UnZTdbMbrX_3iznWKogeJVJ8uSdycxLyAtgb4AxeYaMMVAVg6bim1pW8IicwIazSjMJjw9xo_i3Y_IU8abAQvHmCTnmUmsmZHNCbrcp5S5EO_uO4i70M009TUNv3ZzyHbVjiIlaFzqaPU4pokdqY0e_8kvqf07lEEOKdC5QLPS0C20o0Y8imGlM6Gm35BCv6ehnO6Y87RIGfEaOejugf35YT8mX9-dX24_VxecPn7bvLionJJurGjrYtNaqRkvrvWNccKFBuVb2jeSyFrJ1llsFvQZedlp7zVuuGLR126v6lLzd605LO_rO-ThnO5gph9HmO5NsMH_exLAz1-nWAACTkkFReH1QyOn74nE2Y0Dnh8FGnxY0oEo9UkgQ_4EK4KXvQhb01V_oTVpyLK0olKo3JTNbKdhTLifE7Pv7woGZ1QFm7wBTHGBWB5i13pcPf3z_4vfIC8D3AE7rXHx-kPqfqr8Ap8-82g</recordid><startdate>20170501</startdate><enddate>20170501</enddate><creator>Syed, Adnan S.</creator><creator>Sansone, Alfredo</creator><creator>Hassenklöver, Thomas</creator><creator>Manzini, Ivan</creator><creator>Korsching, Sigrun I.</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SS</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>P64</scope><scope>PATMY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170501</creationdate><title>Coordinated shift of olfactory amino acid responses and V2R expression to an amphibian water nose during metamorphosis</title><author>Syed, Adnan S. ; Sansone, Alfredo ; Hassenklöver, Thomas ; Manzini, Ivan ; Korsching, Sigrun I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c570t-31d14baa8697aeec02525918cb7f6727357bca2a81f91235799e92b2801b3bf83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Amino acids</topic><topic>Amino Acids - metabolism</topic><topic>Amphibians</topic><topic>Animals</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cell Biology</topic><topic>Chemosensory perception</topic><topic>Female</topic><topic>Fish</topic><topic>Gene Expression Regulation, Developmental</topic><topic>Genes</topic><topic>Larva - metabolism</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Metamorphism</topic><topic>Metamorphosis</topic><topic>Metamorphosis, Biological - genetics</topic><topic>Nasal Mucosa - metabolism</topic><topic>Olfactory Mucosa - metabolism</topic><topic>Olfactory Receptor Neurons - metabolism</topic><topic>Original</topic><topic>Original Article</topic><topic>Receptors, Odorant - metabolism</topic><topic>Signal Transduction</topic><topic>Smell</topic><topic>Teleostei</topic><topic>Vomeronasal Organ - metabolism</topic><topic>Water - metabolism</topic><topic>Xenopus</topic><topic>Xenopus laevis - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Syed, Adnan S.</creatorcontrib><creatorcontrib>Sansone, Alfredo</creatorcontrib><creatorcontrib>Hassenklöver, Thomas</creatorcontrib><creatorcontrib>Manzini, Ivan</creatorcontrib><creatorcontrib>Korsching, Sigrun I.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Environmental Science Collection</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cellular and molecular life sciences : CMLS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Syed, Adnan S.</au><au>Sansone, Alfredo</au><au>Hassenklöver, Thomas</au><au>Manzini, Ivan</au><au>Korsching, Sigrun I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Coordinated shift of olfactory amino acid responses and V2R expression to an amphibian water nose during metamorphosis</atitle><jtitle>Cellular and molecular life sciences : CMLS</jtitle><stitle>Cell. Mol. Life Sci</stitle><addtitle>Cell Mol Life Sci</addtitle><date>2017-05-01</date><risdate>2017</risdate><volume>74</volume><issue>9</issue><spage>1711</spage><epage>1719</epage><pages>1711-1719</pages><issn>1420-682X</issn><eissn>1420-9071</eissn><abstract>All olfactory receptors identified in teleost fish are expressed in a single sensory surface, whereas mammalian olfactory receptor gene families segregate into different olfactory organs, chief among them the main olfactory epithelium expressing ORs and TAARs, and the vomeronasal organ expressing V1Rs and V2Rs. A transitional stage is embodied by amphibians, with their vomeronasal organ expressing more ‘modern’, later diverging V2Rs, whereas more ‘ancient’, earlier diverging V2Rs are expressed in the main olfactory epithelium. During metamorphosis, the main olfactory epithelium of
Xenopus
tadpoles transforms into an air-filled cavity (principal cavity, air nose), whereas a newly formed cavity (middle cavity) takes over the function of a water nose. We report here that larval expression of ancient V2Rs is gradually lost from the main olfactory epithelium as it transforms into the air nose. Concomitantly, ancient
v2r
gene expression begins to appear in the basal layers of the newly forming water nose. We observe the same transition for responses to amino acid odorants, consistent with the hypothesis that amino acid responses may be mediated by V2R receptors.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>27990576</pmid><doi>10.1007/s00018-016-2437-1</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Amino acids Amino Acids - metabolism Amphibians Animals Biochemistry Biomedical and Life Sciences Biomedicine Cell Biology Chemosensory perception Female Fish Gene Expression Regulation, Developmental Genes Larva - metabolism Life Sciences Male Metamorphism Metamorphosis Metamorphosis, Biological - genetics Nasal Mucosa - metabolism Olfactory Mucosa - metabolism Olfactory Receptor Neurons - metabolism Original Original Article Receptors, Odorant - metabolism Signal Transduction Smell Teleostei Vomeronasal Organ - metabolism Water - metabolism Xenopus Xenopus laevis - metabolism |
| title | Coordinated shift of olfactory amino acid responses and V2R expression to an amphibian water nose during metamorphosis |
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