A novel anti-viral role for STAT3 in IFN-α signalling responses

The cytokine, Interferon (IFN)-α, induces a wide spectrum of anti-viral mediators, via the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway. STAT1 and STAT2 are well characterised to upregulate IFN-stimulated gene (ISG) expression; but even though STAT3 is also activa...

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Veröffentlicht in:	Cellular and molecular life sciences : CMLS 2017-05, Vol.74 (9), p.1755-1764
Hauptverfasser:	Mahony, Rebecca, Gargan, Siobhán, Roberts, Kim L., Bourke, Nollaig, Keating, Sinead E., Bowie, Andrew G., O’Farrelly, Cliona, Stevenson, Nigel J.
Format:	Artikel
Sprache:	eng
Schlagworte:	2',5'-Oligoadenylate Synthetase - metabolism Amino acids Animals Antiviral agents Biochemistry Biomedical and Life Sciences Biomedicine Cell Biology Cell Line CXCL10 protein Cytokines eIF-2 Kinase - metabolism Embryo fibroblasts Fibroblasts Gene expression Gene Knockdown Techniques Genes Hepatitis C Hepatitis C virus Humans Influenza Influenza A virus - physiology Interferon Interferon-alpha - metabolism Janus kinase Kinases Life Sciences Mice Myxovirus Resistance Proteins Original Original Article Proteasomes Replication Signal Transduction Signaling Stat1 protein Stat2 protein Stat3 protein STAT3 Transcription Factor - metabolism Therapeutic targets Ubiquitin Vaccinia Vaccinia virus - physiology Viral infections Viruses α-Interferon
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