Assembly and regulation of ASC specks

The inflammasome adapter ASC links activated inflammasome sensors to the effector molecule pro-caspase-1. Recruitment of pro-caspase-1 to ASC promotes the autocatalytic activation of caspase-1, which leads to the release of pro-inflammatory cytokines, such as IL-1β. Upon triggering of inflammasome s...

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Veröffentlicht in:Cellular and molecular life sciences : CMLS 2017-04, Vol.74 (7), p.1211-1229
Hauptverfasser: Hoss, Florian, Rodriguez-Alcazar, Juan F., Latz, Eicke
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container_issue 7
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container_title Cellular and molecular life sciences : CMLS
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creator Hoss, Florian
Rodriguez-Alcazar, Juan F.
Latz, Eicke
description The inflammasome adapter ASC links activated inflammasome sensors to the effector molecule pro-caspase-1. Recruitment of pro-caspase-1 to ASC promotes the autocatalytic activation of caspase-1, which leads to the release of pro-inflammatory cytokines, such as IL-1β. Upon triggering of inflammasome sensors, ASC assembles into large helical fibrils that interact with each other serving as a supramolecular signaling platform termed the ASC speck. Alternative splicing, post-translational modifications of ASC, as well as interaction with other proteins can perturb ASC function. In several inflammatory diseases, ASC specks can be found in the extracellular space and its presence correlates with poor prognosis. Here, we review the role of ASC in inflammation, and focus on the structural mechanisms that lead to ASC speck formation, the regulation of ASC function during inflammasome assembly, and the importance of ASC specks in disease.
doi_str_mv 10.1007/s00018-016-2396-6
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Here, we review the role of ASC in inflammation, and focus on the structural mechanisms that lead to ASC speck formation, the regulation of ASC function during inflammasome assembly, and the importance of ASC specks in disease.</description><identifier>ISSN: 1420-682X</identifier><identifier>EISSN: 1420-9071</identifier><identifier>DOI: 10.1007/s00018-016-2396-6</identifier><identifier>PMID: 27761594</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Adapter proteins ; Alternative splicing ; Antigens ; Apoptosis ; Apoptosis Regulatory Proteins - chemistry ; Apoptosis Regulatory Proteins - genetics ; Apoptosis Regulatory Proteins - metabolism ; Assembly ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Cancer ; Carrier Proteins - metabolism ; Caspase-1 ; Cell Biology ; Cytokines ; Enzymes ; Extracellular Matrix - metabolism ; Fibrils ; Gene expression ; Humans ; IL-1β ; Immune system ; Inflammasomes ; Inflammasomes - metabolism ; Inflammation ; Inflammation - metabolism ; Inflammation - pathology ; Inflammatory diseases ; Kinases ; Life Sciences ; Medical research ; Melanoma ; Pathogens ; Post-translation ; Protein Isoforms - chemistry ; Protein Isoforms - genetics ; Protein Isoforms - metabolism ; Protein Multimerization ; Protein Processing, Post-Translational ; Review ; RNA Splicing ; Sensors ; Signal transduction ; Splicing ; Tumor necrosis factor-TNF</subject><ispartof>Cellular and molecular life sciences : CMLS, 2017-04, Vol.74 (7), p.1211-1229</ispartof><rights>Springer International Publishing 2016</rights><rights>Springer International Publishing 2016.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c532t-55becfad7d0e61f69fed45a44ed0103fd5971ec7dadce0855cf707ca180e3ffb3</citedby><cites>FETCH-LOGICAL-c532t-55becfad7d0e61f69fed45a44ed0103fd5971ec7dadce0855cf707ca180e3ffb3</cites><orcidid>0000-0003-1488-5666</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11107573/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11107573/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27915,27916,41479,42548,51310,53782,53784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27761594$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hoss, Florian</creatorcontrib><creatorcontrib>Rodriguez-Alcazar, Juan F.</creatorcontrib><creatorcontrib>Latz, Eicke</creatorcontrib><title>Assembly and regulation of ASC specks</title><title>Cellular and molecular life sciences : CMLS</title><addtitle>Cell. 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subjects Adapter proteins
Alternative splicing
Antigens
Apoptosis
Apoptosis Regulatory Proteins - chemistry
Apoptosis Regulatory Proteins - genetics
Apoptosis Regulatory Proteins - metabolism
Assembly
Biochemistry
Biomedical and Life Sciences
Biomedicine
Cancer
Carrier Proteins - metabolism
Caspase-1
Cell Biology
Cytokines
Enzymes
Extracellular Matrix - metabolism
Fibrils
Gene expression
Humans
IL-1β
Immune system
Inflammasomes
Inflammasomes - metabolism
Inflammation
Inflammation - metabolism
Inflammation - pathology
Inflammatory diseases
Kinases
Life Sciences
Medical research
Melanoma
Pathogens
Post-translation
Protein Isoforms - chemistry
Protein Isoforms - genetics
Protein Isoforms - metabolism
Protein Multimerization
Protein Processing, Post-Translational
Review
RNA Splicing
Sensors
Signal transduction
Splicing
Tumor necrosis factor-TNF
title Assembly and regulation of ASC specks
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