OX40 promotes obesity-induced adipose inflammation and insulin resistance

Adaptive immunity plays a critical role in IR and T2DM development; however, the biological mechanisms linking T cell costimulation and glucose metabolism have not been fully elucidated. In this study, we demonstrated that the costimulatory molecule OX40 controls T cell activation and IR development...

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Veröffentlicht in:	Cellular and molecular life sciences : CMLS 2017-10, Vol.74 (20), p.3827-3840
Hauptverfasser:	Liu, Bing, Yu, Hengchi, Sun, Guangyong, Sun, Xiaojing, Jin, Hua, Zhang, Chunpan, Shi, Wen, Tian, Dan, Liu, Kai, Xu, Hufeng, Li, Xinmin, Yin, Jie, Hong, Xu, Zhang, Dong
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive immunity Adipose tissue Adipose Tissue - immunology Adipose Tissue - metabolism Animal tissues Animals Biochemistry Biomedical and Life Sciences Biomedicine Body weight gain CD4 antigen CD4-Positive T-Lymphocytes - immunology Cell activation Cell Biology Cell differentiation Cells, Cultured Differentiation (biology) Fasting Gene expression Glucose Glucose metabolism Humans Immunity Inflammation Inflammation - etiology Inflammation - genetics Inflammation - immunology Insulin Insulin Resistance Life Sciences Lymphocyte Activation Lymphocytes Lymphocytes T Macrophages - immunology Male Metabolism Mice Mice, Inbred C57BL Mice, Knockout Obesity Obesity - complications Obesity - genetics Obesity - immunology Original Original Article Promotion Receptors, OX40 - genetics Receptors, OX40 - immunology Rodents Signal transduction T cell receptors T-Lymphocytes, Regulatory - immunology Th1 Cells - immunology Tumor necrosis factor Up-Regulation
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