Characterization of two transcriptomic subtypes of marker-null large cell carcinoma of the lung suggests different origin and potential new therapeutic perspectives

Pulmonary large cell carcinoma (LCC) is an undifferentiated neoplasm lacking morphological, histochemical, and immunohistochemical features of small cell lung cancer, adenocarcinoma (ADC), or squamous cell carcinoma (SCC). The available molecular information on this rare disease is limited. This stu...

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Veröffentlicht in:	Virchows Archiv : an international journal of pathology 2024-05, Vol.484 (5), p.777-788
Hauptverfasser:	Simbolo, Michele, Centonze, Giovanni, Gkountakos, Anastasios, Monti, Valentina, Maisonneuve, Patrick, Golovco, Stela, Sabella, Giovanna, Del Gobbo, Alessandro, Gobbo, Stefano, Ferrero, Stefano, Fabbri, Alessandra, Pardo, Carlotta, Garzone, Giovanna, Prinzi, Natalie, Pusceddu, Sara, Testi, Adele, Rolli, Luigi, Mangogna, Alessandro, Bercich, Luisa, Benvenuti, Mauro Roberto, Bria, Emilio, Pilotto, Sara, Berruti, Alfredo, Pastorino, Ugo, Capella, Carlo, Infante, Maurizio, Milella, Michele, Scarpa, Aldo, Milione, Massimo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Alveoli Cancer Differential diagnosis Gene expression Genes Immunohistochemistry Inflammasomes Lung cancer Lung carcinoma Medicine Medicine & Public Health Myc protein Original Original Article p53 Protein Pathology Replication Small cell lung carcinoma Squamous cell carcinoma Transcriptomics
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