Baseline prepulse inhibition dependency of orexin A and REM sleep deprivation

Rationale Prepulse inhibition (PPI) impairment reflects sensorimotor gating problems, i.e. in schizophrenia. This study aims to enlighten the role of orexinergic regulation on PPI in a psychosis-like model. Objectives In order to understand the impact of orexinergic innervation on PPI and how it is...

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Veröffentlicht in:	Psychopharmacology 2024-06, Vol.241 (6), p.1213-1225
Hauptverfasser:	Öz, Pınar, Kamalı, Osman, Saka, Hacer Begüm, Gör, Ceren, Uzbay, İsmail Tayfun
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Animal models Animals Biomedical and Life Sciences Biomedicine Disease Models, Animal Innervation Male Mental disorders Neurosciences Orexins Orexins - administration & dosage Orexins - metabolism Orexins - pharmacology Original Investigation Pharmacology/Toxicology Prepulse Inhibition - drug effects Prepulse Inhibition - physiology Psychiatry Psychosis Rats Rats, Wistar REM sleep Schizophrenia Sensorimotor gating Sensory Gating - drug effects Sleep and wakefulness Sleep deprivation Sleep Deprivation - physiopathology Sleep, REM - drug effects Therapeutic targets
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