Microcystin–leucine–arginine causes blood–testis barrier disruption and degradation of occludin mediated by matrix metalloproteinase-8

Microcystin–leucine–arginine (MC-LR) can cause male reproductive disorders. However, the underlying mechanisms are not yet fully understood. In this study, we aimed to investigate the effects of MC-LR on the integrity of blood–testis barrier (BTB) and the related molecular mechanisms. Both transepit...

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Veröffentlicht in:	Cellular and molecular life sciences : CMLS 2018-03, Vol.75 (6), p.1117-1132
Hauptverfasser:	Chen, Yabing, Wang, Jing, Pan, Chun, Li, Dongmei, Han, Xiaodong
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein Animals Arginine Bacterial Toxins - toxicity Biochemistry Biodegradation Biomedical and Life Sciences Biomedicine Blood Blood-brain barrier Blood-Testis Barrier - drug effects Blood-Testis Barrier - metabolism Blood-Testis Barrier - ultrastructure c-Fos protein c-Jun protein Cascades Cell Biology Cell Line Chromosome 3 Degradation Extracellular signal-regulated kinase Gene Expression Regulation - drug effects Infertility Leucine Life Sciences Male Matrix Matrix metalloproteinase Matrix Metalloproteinase 8 - genetics Matrix Metalloproteinase 8 - metabolism Metalloproteinase Mice Mice, Inbred BALB C Mice, Inbred ICR Microcystins Microcystins - toxicity MicroRNAs - genetics MicroRNAs - metabolism Mitogen-Activated Protein Kinase 1 - genetics Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - genetics Mitogen-Activated Protein Kinase 3 - metabolism Molecular modelling Neutrophil collagenase NF-kappa B - genetics NF-kappa B - metabolism NF-κB protein Occludin - genetics Occludin - metabolism Original Original Article Phosphatidylinositol 3-Kinases - genetics Phosphatidylinositol 3-Kinases - metabolism Post-transcription Primary Cell Culture Proteins Proteolysis Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism Proto-Oncogene Proteins c-fos - genetics Proto-Oncogene Proteins c-fos - metabolism Proto-Oncogene Proteins c-jun - genetics Proto-Oncogene Proteins c-jun - metabolism Reproductive disorders RNA, Small Interfering - genetics RNA, Small Interfering - metabolism Sertoli cells Sertoli Cells - cytology Sertoli Cells - drug effects Sertoli Cells - metabolism Tight Junctions - drug effects Tight Junctions - metabolism Tight Junctions - ultrastructure Transcription factors Transfection
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