The biological functions and clinical applications of exosomes in lung cancer
Lung cancer remains the leading cause of cancer-related death worldwide, and the high incidence rates are worrisome. Exosomes are a class of extracellular vesicles secreted by most cells, including RNAs, proteins and lipids. Exosomes can mediate cell-to-cell communication in both physiologic and pat...
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| Veröffentlicht in: | Cellular and molecular life sciences : CMLS 2019-12, Vol.76 (23), p.4613-4633 |
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| creator | Chen, Rui Xu, Xin Qian, Zijun Zhang, Congcong Niu, Yongjie Wang, Zhixian Sun, Jianli Zhang, Xiao Yu, Yongchun |
| description | Lung cancer remains the leading cause of cancer-related death worldwide, and the high incidence rates are worrisome. Exosomes are a class of extracellular vesicles secreted by most cells, including RNAs, proteins and lipids. Exosomes can mediate cell-to-cell communication in both physiologic and pathologic processes. Accumulated evidences show that cancer-derived exosomes aid in the recruitment and reprogramming of constituents correlated with tumor microenvironment. Furthermore, exosome-based clinical trials have been completed in advanced lung cancer patients. In this review, we discuss the roles of exosomes in a lung cancer microenvironment, such as its participation in lung cancer initiation, progression and metastasis as well as being involved in angiogenesis, epithelial–mesenchymal transition (EMT), immune escape, and drug resistance. In addition, we focus on the potential of exosomes as diagnostic and prognostic biomarkers in lung cancer, as well as the challenges faced by and advantages of exosomes as drug delivery vehicles and in exosome-based immunotherapy. |
| doi_str_mv | 10.1007/s00018-019-03233-y |
| format | Article |
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Exosomes are a class of extracellular vesicles secreted by most cells, including RNAs, proteins and lipids. Exosomes can mediate cell-to-cell communication in both physiologic and pathologic processes. Accumulated evidences show that cancer-derived exosomes aid in the recruitment and reprogramming of constituents correlated with tumor microenvironment. Furthermore, exosome-based clinical trials have been completed in advanced lung cancer patients. In this review, we discuss the roles of exosomes in a lung cancer microenvironment, such as its participation in lung cancer initiation, progression and metastasis as well as being involved in angiogenesis, epithelial–mesenchymal transition (EMT), immune escape, and drug resistance. In addition, we focus on the potential of exosomes as diagnostic and prognostic biomarkers in lung cancer, as well as the challenges faced by and advantages of exosomes as drug delivery vehicles and in exosome-based immunotherapy.</description><identifier>ISSN: 1420-682X</identifier><identifier>EISSN: 1420-9071</identifier><identifier>DOI: 10.1007/s00018-019-03233-y</identifier><identifier>PMID: 31352532</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Angiogenesis ; Biochemistry ; Biomarkers ; Biomedical and Life Sciences ; Biomedicine ; Cell Biology ; Cell Communication ; Cell interactions ; Clinical trials ; Diagnostic systems ; Drug delivery ; Drug delivery systems ; Drug resistance ; Drug Resistance, Neoplasm ; Epithelial-Mesenchymal Transition ; Exosomes ; Exosomes - metabolism ; Humans ; Immunosuppression Therapy ; Immunotherapy ; Life Sciences ; Lipids ; Lung cancer ; Lung Neoplasms - blood supply ; Lung Neoplasms - metabolism ; Lung Neoplasms - pathology ; Medical research ; Mesenchyme ; Metastases ; Neoplasm Metastasis ; Neovascularization, Pathologic ; Review ; Therapeutic applications ; Tumor Microenvironment</subject><ispartof>Cellular and molecular life sciences : CMLS, 2019-12, Vol.76 (23), p.4613-4633</ispartof><rights>Springer Nature Switzerland AG 2019</rights><rights>Cellular and Molecular Life Sciences is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c541t-d2857ceeb9649642d2cd7c2f9b0d4035c4c90eb8659dec0ee41c6d6099e8b24a3</citedby><cites>FETCH-LOGICAL-c541t-d2857ceeb9649642d2cd7c2f9b0d4035c4c90eb8659dec0ee41c6d6099e8b24a3</cites><orcidid>0000-0002-9112-1347</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11105651/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11105651/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,41464,42533,51294,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31352532$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Rui</creatorcontrib><creatorcontrib>Xu, Xin</creatorcontrib><creatorcontrib>Qian, Zijun</creatorcontrib><creatorcontrib>Zhang, Congcong</creatorcontrib><creatorcontrib>Niu, Yongjie</creatorcontrib><creatorcontrib>Wang, Zhixian</creatorcontrib><creatorcontrib>Sun, Jianli</creatorcontrib><creatorcontrib>Zhang, Xiao</creatorcontrib><creatorcontrib>Yu, Yongchun</creatorcontrib><title>The biological functions and clinical applications of exosomes in lung cancer</title><title>Cellular and molecular life sciences : CMLS</title><addtitle>Cell. Mol. Life Sci</addtitle><addtitle>Cell Mol Life Sci</addtitle><description>Lung cancer remains the leading cause of cancer-related death worldwide, and the high incidence rates are worrisome. Exosomes are a class of extracellular vesicles secreted by most cells, including RNAs, proteins and lipids. Exosomes can mediate cell-to-cell communication in both physiologic and pathologic processes. Accumulated evidences show that cancer-derived exosomes aid in the recruitment and reprogramming of constituents correlated with tumor microenvironment. Furthermore, exosome-based clinical trials have been completed in advanced lung cancer patients. In this review, we discuss the roles of exosomes in a lung cancer microenvironment, such as its participation in lung cancer initiation, progression and metastasis as well as being involved in angiogenesis, epithelial–mesenchymal transition (EMT), immune escape, and drug resistance. In addition, we focus on the potential of exosomes as diagnostic and prognostic biomarkers in lung cancer, as well as the challenges faced by and advantages of exosomes as drug delivery vehicles and in exosome-based immunotherapy.</description><subject>Angiogenesis</subject><subject>Biochemistry</subject><subject>Biomarkers</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell Biology</subject><subject>Cell Communication</subject><subject>Cell interactions</subject><subject>Clinical trials</subject><subject>Diagnostic systems</subject><subject>Drug delivery</subject><subject>Drug delivery systems</subject><subject>Drug resistance</subject><subject>Drug Resistance, Neoplasm</subject><subject>Epithelial-Mesenchymal Transition</subject><subject>Exosomes</subject><subject>Exosomes - metabolism</subject><subject>Humans</subject><subject>Immunosuppression Therapy</subject><subject>Immunotherapy</subject><subject>Life Sciences</subject><subject>Lipids</subject><subject>Lung cancer</subject><subject>Lung Neoplasms - blood supply</subject><subject>Lung Neoplasms - metabolism</subject><subject>Lung Neoplasms - pathology</subject><subject>Medical research</subject><subject>Mesenchyme</subject><subject>Metastases</subject><subject>Neoplasm Metastasis</subject><subject>Neovascularization, Pathologic</subject><subject>Review</subject><subject>Therapeutic applications</subject><subject>Tumor Microenvironment</subject><issn>1420-682X</issn><issn>1420-9071</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kctqHDEQRUVIsB3bP-CFacgmm05Kz26tjDF5gUM2DmQn1OrqsYxGmkjTIfP3kd1j57EICFTonrqq4hJyRuENBejeFgCgfQtUt8AZ5-3uGTmigkGroaPP97Xq2bdD8rKUu0rLnqkDcsgpl0xydkQ-39xiM_gU0so7G5ppjm7rUyyNjWPjgo8Pz3azCbVYlDQ1-DOVtMbS-NiEOa4aZ6PDfEJeTDYUPN3fx-Tr-3c3Vx_b6y8fPl1dXrdOCrptR9bLziEOWol62Mjc2Dk26QFGAVw64TTg0CupR3SAKKhTowKtsR-YsPyYXCy-m3lY4-gwbrMNZpP92uadSdabv5Xob80q_TCUUpBK0urweu-Q0_cZy9asfXEYgo2Y5mIYU4oLqONV9NU_6F2ac6z73VOi07pjUCm2UC6nUjJOT9NQMPdxmSUuU-MyD3GZXW06_3OPp5bHfCrAF6BUKa4w__77P7a_ABIHodY</recordid><startdate>20191201</startdate><enddate>20191201</enddate><creator>Chen, Rui</creator><creator>Xu, Xin</creator><creator>Qian, Zijun</creator><creator>Zhang, Congcong</creator><creator>Niu, Yongjie</creator><creator>Wang, Zhixian</creator><creator>Sun, Jianli</creator><creator>Zhang, Xiao</creator><creator>Yu, Yongchun</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SS</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>P64</scope><scope>PATMY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-9112-1347</orcidid></search><sort><creationdate>20191201</creationdate><title>The biological functions and clinical applications of exosomes in lung cancer</title><author>Chen, Rui ; Xu, Xin ; Qian, Zijun ; Zhang, Congcong ; Niu, Yongjie ; Wang, Zhixian ; Sun, Jianli ; Zhang, Xiao ; Yu, Yongchun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c541t-d2857ceeb9649642d2cd7c2f9b0d4035c4c90eb8659dec0ee41c6d6099e8b24a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Angiogenesis</topic><topic>Biochemistry</topic><topic>Biomarkers</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cell Biology</topic><topic>Cell Communication</topic><topic>Cell interactions</topic><topic>Clinical trials</topic><topic>Diagnostic systems</topic><topic>Drug delivery</topic><topic>Drug delivery systems</topic><topic>Drug resistance</topic><topic>Drug Resistance, Neoplasm</topic><topic>Epithelial-Mesenchymal Transition</topic><topic>Exosomes</topic><topic>Exosomes - metabolism</topic><topic>Humans</topic><topic>Immunosuppression Therapy</topic><topic>Immunotherapy</topic><topic>Life Sciences</topic><topic>Lipids</topic><topic>Lung cancer</topic><topic>Lung Neoplasms - blood supply</topic><topic>Lung Neoplasms - metabolism</topic><topic>Lung Neoplasms - pathology</topic><topic>Medical research</topic><topic>Mesenchyme</topic><topic>Metastases</topic><topic>Neoplasm Metastasis</topic><topic>Neovascularization, Pathologic</topic><topic>Review</topic><topic>Therapeutic applications</topic><topic>Tumor Microenvironment</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Rui</creatorcontrib><creatorcontrib>Xu, Xin</creatorcontrib><creatorcontrib>Qian, Zijun</creatorcontrib><creatorcontrib>Zhang, Congcong</creatorcontrib><creatorcontrib>Niu, Yongjie</creatorcontrib><creatorcontrib>Wang, Zhixian</creatorcontrib><creatorcontrib>Sun, Jianli</creatorcontrib><creatorcontrib>Zhang, Xiao</creatorcontrib><creatorcontrib>Yu, Yongchun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Environmental Science Collection</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cellular and molecular life sciences : CMLS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Rui</au><au>Xu, Xin</au><au>Qian, Zijun</au><au>Zhang, Congcong</au><au>Niu, Yongjie</au><au>Wang, Zhixian</au><au>Sun, Jianli</au><au>Zhang, Xiao</au><au>Yu, Yongchun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The biological functions and clinical applications of exosomes in lung cancer</atitle><jtitle>Cellular and molecular life sciences : CMLS</jtitle><stitle>Cell. Mol. Life Sci</stitle><addtitle>Cell Mol Life Sci</addtitle><date>2019-12-01</date><risdate>2019</risdate><volume>76</volume><issue>23</issue><spage>4613</spage><epage>4633</epage><pages>4613-4633</pages><issn>1420-682X</issn><eissn>1420-9071</eissn><abstract>Lung cancer remains the leading cause of cancer-related death worldwide, and the high incidence rates are worrisome. Exosomes are a class of extracellular vesicles secreted by most cells, including RNAs, proteins and lipids. Exosomes can mediate cell-to-cell communication in both physiologic and pathologic processes. Accumulated evidences show that cancer-derived exosomes aid in the recruitment and reprogramming of constituents correlated with tumor microenvironment. Furthermore, exosome-based clinical trials have been completed in advanced lung cancer patients. In this review, we discuss the roles of exosomes in a lung cancer microenvironment, such as its participation in lung cancer initiation, progression and metastasis as well as being involved in angiogenesis, epithelial–mesenchymal transition (EMT), immune escape, and drug resistance. In addition, we focus on the potential of exosomes as diagnostic and prognostic biomarkers in lung cancer, as well as the challenges faced by and advantages of exosomes as drug delivery vehicles and in exosome-based immunotherapy.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>31352532</pmid><doi>10.1007/s00018-019-03233-y</doi><tpages>21</tpages><orcidid>https://orcid.org/0000-0002-9112-1347</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Angiogenesis Biochemistry Biomarkers Biomedical and Life Sciences Biomedicine Cell Biology Cell Communication Cell interactions Clinical trials Diagnostic systems Drug delivery Drug delivery systems Drug resistance Drug Resistance, Neoplasm Epithelial-Mesenchymal Transition Exosomes Exosomes - metabolism Humans Immunosuppression Therapy Immunotherapy Life Sciences Lipids Lung cancer Lung Neoplasms - blood supply Lung Neoplasms - metabolism Lung Neoplasms - pathology Medical research Mesenchyme Metastases Neoplasm Metastasis Neovascularization, Pathologic Review Therapeutic applications Tumor Microenvironment |
| title | The biological functions and clinical applications of exosomes in lung cancer |
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