Mitochondrial functions and melatonin: a tour of the reproductive cancers
Cancers of the reproductive organs have a strong association with mitochondrial defects, and a deeper understanding of the role of this organelle in preneoplastic–neoplastic changes is important to determine the appropriate therapeutic intervention. Mitochondria are involved in events during cancer...
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| Veröffentlicht in: | Cellular and molecular life sciences : CMLS 2019-03, Vol.76 (5), p.837-863 |
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| creator | de Almeida Chuffa, Luiz Gustavo Seiva, Fábio Rodrigues Ferreira Cucielo, Maira Smaniotto Silveira, Henrique Spaulonci Reiter, Russel J. Lupi, Luiz Antonio |
| description | Cancers of the reproductive organs have a strong association with mitochondrial defects, and a deeper understanding of the role of this organelle in preneoplastic–neoplastic changes is important to determine the appropriate therapeutic intervention. Mitochondria are involved in events during cancer development, including metabolic and oxidative status, acquisition of metastatic potential, resistance to chemotherapy, apoptosis, and others. Because of their origin from melatonin-producing bacteria, mitochondria are speculated to produce melatonin and its derivatives at high levels; in addition, exogenously administered melatonin accumulates in the mitochondria against a concentration gradient. Melatonin is transported into tumor cell by GLUT/SLC2A and/or by the PEPT1/2 transporters, and plays beneficial roles in mitochondrial homeostasis, such as influencing oxidative phosphorylation and electron flux, ATP synthesis, bioenergetics, calcium influx, and mitochondrial permeability transition pore. Moreover, melatonin promotes mitochondrial homeostasis by regulating nuclear DNA and mtDNA transcriptional activities. This review focuses on the main functions of melatonin on mitochondrial processes, and reviews from a mechanistic standpoint, how mitochondrial crosstalk evolved in ovarian, endometrial, cervical, breast, and prostate cancers relative to melatonin’s known actions. We put emphasis on signaling pathways whereby melatonin interferes within cancer-cell mitochondria after its administration. Depending on subtype and intratumor metabolic heterogeneity, melatonin seems to be helpful in promoting apoptosis, anti-proliferation, pro-oxidation, metabolic shifting, inhibiting neovasculogenesis and controlling inflammation, and restoration of chemosensitivity. This results in attenuation of development, progression, and metastatic potential of reproductive cancers, in addition to lowering the risk of recurrence and improving the life quality of patients. |
| doi_str_mv | 10.1007/s00018-018-2963-0 |
| format | Article |
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Mitochondria are involved in events during cancer development, including metabolic and oxidative status, acquisition of metastatic potential, resistance to chemotherapy, apoptosis, and others. Because of their origin from melatonin-producing bacteria, mitochondria are speculated to produce melatonin and its derivatives at high levels; in addition, exogenously administered melatonin accumulates in the mitochondria against a concentration gradient. Melatonin is transported into tumor cell by GLUT/SLC2A and/or by the PEPT1/2 transporters, and plays beneficial roles in mitochondrial homeostasis, such as influencing oxidative phosphorylation and electron flux, ATP synthesis, bioenergetics, calcium influx, and mitochondrial permeability transition pore. Moreover, melatonin promotes mitochondrial homeostasis by regulating nuclear DNA and mtDNA transcriptional activities. This review focuses on the main functions of melatonin on mitochondrial processes, and reviews from a mechanistic standpoint, how mitochondrial crosstalk evolved in ovarian, endometrial, cervical, breast, and prostate cancers relative to melatonin’s known actions. We put emphasis on signaling pathways whereby melatonin interferes within cancer-cell mitochondria after its administration. Depending on subtype and intratumor metabolic heterogeneity, melatonin seems to be helpful in promoting apoptosis, anti-proliferation, pro-oxidation, metabolic shifting, inhibiting neovasculogenesis and controlling inflammation, and restoration of chemosensitivity. This results in attenuation of development, progression, and metastatic potential of reproductive cancers, in addition to lowering the risk of recurrence and improving the life quality of patients.</description><identifier>ISSN: 1420-682X</identifier><identifier>EISSN: 1420-9071</identifier><identifier>DOI: 10.1007/s00018-018-2963-0</identifier><identifier>PMID: 30430198</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Animals ; Apoptosis ; Attenuation ; Biochemistry ; Bioenergetics ; Biomedical and Life Sciences ; Biomedicine ; Breast cancer ; Breast Neoplasms - pathology ; Calcium (mitochondrial) ; Calcium influx ; Calcium permeability ; Cancer ; Cell Biology ; Cervical cancer ; Cervix ; Chemotherapy ; Concentration gradient ; Crosstalk ; Deoxyribonucleic acid ; DNA ; Electron density ; Endometrial cancer ; Endometrial Neoplasms - pathology ; Endometrium ; Female ; Genital Neoplasms, Female - pathology ; Heterogeneity ; Homeostasis ; Humans ; Life Sciences ; Male ; Melatonin ; Melatonin - physiology ; Membrane permeability ; Metabolism ; Metastases ; Metastasis ; Mitochondria ; Mitochondria - physiology ; Mitochondrial DNA ; Mitochondrial permeability transition pore ; Organs ; Ovarian cancer ; Ovarian Neoplasms - pathology ; Oxidation ; Oxidation resistance ; Oxidative phosphorylation ; Oxidative Stress ; Phosphorylation ; Prostate ; Prostate cancer ; Prostatic Neoplasms - pathology ; Quality of life ; Reactive Oxygen Species - metabolism ; Reproductive organs ; Restoration ; Review ; Signal Transduction ; Transcription ; Uterine Cervical Neoplasms - pathology</subject><ispartof>Cellular and molecular life sciences : CMLS, 2019-03, Vol.76 (5), p.837-863</ispartof><rights>Springer Nature Switzerland AG 2018</rights><rights>Cellular and Molecular Life Sciences is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c471t-86290714958666c46a46c15b811c401ce13871c95cdb66527259de7c34a7abcf3</citedby><cites>FETCH-LOGICAL-c471t-86290714958666c46a46c15b811c401ce13871c95cdb66527259de7c34a7abcf3</cites><orcidid>0000-0002-0199-3396</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11105419/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11105419/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,41488,42557,51319,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30430198$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de Almeida Chuffa, Luiz Gustavo</creatorcontrib><creatorcontrib>Seiva, Fábio Rodrigues Ferreira</creatorcontrib><creatorcontrib>Cucielo, Maira Smaniotto</creatorcontrib><creatorcontrib>Silveira, Henrique Spaulonci</creatorcontrib><creatorcontrib>Reiter, Russel J.</creatorcontrib><creatorcontrib>Lupi, Luiz Antonio</creatorcontrib><title>Mitochondrial functions and melatonin: a tour of the reproductive cancers</title><title>Cellular and molecular life sciences : CMLS</title><addtitle>Cell. Mol. Life Sci</addtitle><addtitle>Cell Mol Life Sci</addtitle><description>Cancers of the reproductive organs have a strong association with mitochondrial defects, and a deeper understanding of the role of this organelle in preneoplastic–neoplastic changes is important to determine the appropriate therapeutic intervention. Mitochondria are involved in events during cancer development, including metabolic and oxidative status, acquisition of metastatic potential, resistance to chemotherapy, apoptosis, and others. Because of their origin from melatonin-producing bacteria, mitochondria are speculated to produce melatonin and its derivatives at high levels; in addition, exogenously administered melatonin accumulates in the mitochondria against a concentration gradient. 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Depending on subtype and intratumor metabolic heterogeneity, melatonin seems to be helpful in promoting apoptosis, anti-proliferation, pro-oxidation, metabolic shifting, inhibiting neovasculogenesis and controlling inflammation, and restoration of chemosensitivity. This results in attenuation of development, progression, and metastatic potential of reproductive cancers, in addition to lowering the risk of recurrence and improving the life quality of patients.</description><subject>Animals</subject><subject>Apoptosis</subject><subject>Attenuation</subject><subject>Biochemistry</subject><subject>Bioenergetics</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - pathology</subject><subject>Calcium (mitochondrial)</subject><subject>Calcium influx</subject><subject>Calcium permeability</subject><subject>Cancer</subject><subject>Cell Biology</subject><subject>Cervical cancer</subject><subject>Cervix</subject><subject>Chemotherapy</subject><subject>Concentration gradient</subject><subject>Crosstalk</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Electron density</subject><subject>Endometrial cancer</subject><subject>Endometrial Neoplasms - 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pathology</topic><topic>Calcium (mitochondrial)</topic><topic>Calcium influx</topic><topic>Calcium permeability</topic><topic>Cancer</topic><topic>Cell Biology</topic><topic>Cervical cancer</topic><topic>Cervix</topic><topic>Chemotherapy</topic><topic>Concentration gradient</topic><topic>Crosstalk</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>Electron density</topic><topic>Endometrial cancer</topic><topic>Endometrial Neoplasms - pathology</topic><topic>Endometrium</topic><topic>Female</topic><topic>Genital Neoplasms, Female - pathology</topic><topic>Heterogeneity</topic><topic>Homeostasis</topic><topic>Humans</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Melatonin</topic><topic>Melatonin - physiology</topic><topic>Membrane permeability</topic><topic>Metabolism</topic><topic>Metastases</topic><topic>Metastasis</topic><topic>Mitochondria</topic><topic>Mitochondria - physiology</topic><topic>Mitochondrial DNA</topic><topic>Mitochondrial permeability transition pore</topic><topic>Organs</topic><topic>Ovarian cancer</topic><topic>Ovarian Neoplasms - 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Mol. Life Sci</stitle><addtitle>Cell Mol Life Sci</addtitle><date>2019-03-01</date><risdate>2019</risdate><volume>76</volume><issue>5</issue><spage>837</spage><epage>863</epage><pages>837-863</pages><issn>1420-682X</issn><eissn>1420-9071</eissn><abstract>Cancers of the reproductive organs have a strong association with mitochondrial defects, and a deeper understanding of the role of this organelle in preneoplastic–neoplastic changes is important to determine the appropriate therapeutic intervention. Mitochondria are involved in events during cancer development, including metabolic and oxidative status, acquisition of metastatic potential, resistance to chemotherapy, apoptosis, and others. Because of their origin from melatonin-producing bacteria, mitochondria are speculated to produce melatonin and its derivatives at high levels; in addition, exogenously administered melatonin accumulates in the mitochondria against a concentration gradient. Melatonin is transported into tumor cell by GLUT/SLC2A and/or by the PEPT1/2 transporters, and plays beneficial roles in mitochondrial homeostasis, such as influencing oxidative phosphorylation and electron flux, ATP synthesis, bioenergetics, calcium influx, and mitochondrial permeability transition pore. Moreover, melatonin promotes mitochondrial homeostasis by regulating nuclear DNA and mtDNA transcriptional activities. This review focuses on the main functions of melatonin on mitochondrial processes, and reviews from a mechanistic standpoint, how mitochondrial crosstalk evolved in ovarian, endometrial, cervical, breast, and prostate cancers relative to melatonin’s known actions. We put emphasis on signaling pathways whereby melatonin interferes within cancer-cell mitochondria after its administration. Depending on subtype and intratumor metabolic heterogeneity, melatonin seems to be helpful in promoting apoptosis, anti-proliferation, pro-oxidation, metabolic shifting, inhibiting neovasculogenesis and controlling inflammation, and restoration of chemosensitivity. This results in attenuation of development, progression, and metastatic potential of reproductive cancers, in addition to lowering the risk of recurrence and improving the life quality of patients.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>30430198</pmid><doi>10.1007/s00018-018-2963-0</doi><tpages>27</tpages><orcidid>https://orcid.org/0000-0002-0199-3396</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Cellular and molecular life sciences : CMLS, 2019-03, Vol.76 (5), p.837-863 |
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| language | eng |
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| source | MEDLINE; SpringerNature Journals; PubMed Central |
| subjects | Animals Apoptosis Attenuation Biochemistry Bioenergetics Biomedical and Life Sciences Biomedicine Breast cancer Breast Neoplasms - pathology Calcium (mitochondrial) Calcium influx Calcium permeability Cancer Cell Biology Cervical cancer Cervix Chemotherapy Concentration gradient Crosstalk Deoxyribonucleic acid DNA Electron density Endometrial cancer Endometrial Neoplasms - pathology Endometrium Female Genital Neoplasms, Female - pathology Heterogeneity Homeostasis Humans Life Sciences Male Melatonin Melatonin - physiology Membrane permeability Metabolism Metastases Metastasis Mitochondria Mitochondria - physiology Mitochondrial DNA Mitochondrial permeability transition pore Organs Ovarian cancer Ovarian Neoplasms - pathology Oxidation Oxidation resistance Oxidative phosphorylation Oxidative Stress Phosphorylation Prostate Prostate cancer Prostatic Neoplasms - pathology Quality of life Reactive Oxygen Species - metabolism Reproductive organs Restoration Review Signal Transduction Transcription Uterine Cervical Neoplasms - pathology |
| title | Mitochondrial functions and melatonin: a tour of the reproductive cancers |
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