Adamts17 is involved in skeletogenesis through modulation of BMP-Smad1/5/8 pathway

Fibrillin microfibrils are ubiquitous elements of extracellular matrix assemblies that play crucial roles in regulating the bioavailability of growth factors of the transforming growth factor beta superfamily. Recently, several “a disintegrin and metalloproteinase with thrombospondin motifs” (ADAMTS...

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Veröffentlicht in:	Cellular and molecular life sciences : CMLS 2019-12, Vol.76 (23), p.4795-4809
Hauptverfasser:	Oichi, Takeshi, Taniguchi, Yuki, Soma, Kazuhito, Oshima, Yasushi, Yano, Fumiko, Mori, Yoshifumi, Chijimatsu, Ryota, Kim-Kaneyama, Joo-ri, Tanaka, Sakae, Saito, Taku
Format:	Artikel
Sprache:	eng
Schlagworte:	ADAM protein ADAMTS Proteins - genetics ADAMTS Proteins - physiology Animals Bioavailability Biochemistry Biomedical and Life Sciences Biomedicine Bone morphogenetic proteins Bone Morphogenetic Proteins - metabolism Bone Morphogenetic Proteins - pharmacology Bones Brachydactyly Cell Biology Cell Differentiation - drug effects Cells, Cultured Chondrocytes Chondrocytes - cytology Chondrocytes - metabolism Chondrogenesis Eutrophication Extracellular matrix Fibrillin Fibrillin-2 - metabolism Gene expression Gene sequencing Growth factors Growth plate Life Sciences Metatarsus Mice Mice, Inbred C57BL Mice, Knockout Microfibrils Microfibrils - metabolism Molecular modelling Muscle, Skeletal - growth & development Muscle, Skeletal - pathology Original Original Article Proteins Ribonucleic acid RNA Signal Transduction Signs and symptoms Skeletogenesis Skin Skin - physiopathology Smad1 Protein - metabolism Smad5 Protein - metabolism Smad8 Protein - metabolism Therapeutic applications Thrombospondin Transforming growth factor-b Weill-Marchesani Syndrome - metabolism Weill-Marchesani Syndrome - pathology Weill-Marchesani Syndrome - veterinary
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