OSBP-related protein-2 (ORP2): a novel Akt effector that controls cellular energy metabolism

ORP2 is a ubiquitously expressed OSBP-related protein previously implicated in endoplasmic reticulum (ER)—lipid droplet (LD) contacts, triacylglycerol (TG) metabolism, cholesterol transport, adrenocortical steroidogenesis, and actin-dependent cell dynamics. Here, we characterize the role of ORP2 in...

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Veröffentlicht in:	Cellular and molecular life sciences : CMLS 2018-11, Vol.75 (21), p.4041-4057
Hauptverfasser:	Kentala, Henriikka, Koponen, Annika, Vihinen, Helena, Pirhonen, Juho, Liebisch, Gerhard, Pataj, Zoltan, Kivelä, Annukka, Li, Shiqian, Karhinen, Leena, Jääskeläinen, Eeva, Andrews, Robert, Meriläinen, Leena, Matysik, Silke, Ikonen, Elina, Zhou, You, Jokitalo, Eija, Olkkonen, Vesa M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acidification Actin Actin Cytoskeleton - genetics Actin Cytoskeleton - metabolism AKT protein Biochemistry Biological Transport - genetics Biomedical and Life Sciences Biomedicine Carbohydrate metabolism Carbohydrates Cell adhesion & migration Cell Biology Cell culture Cell Cycle Proteins - genetics Cell Line Cell migration Cell Movement - genetics Cell Proliferation - genetics Chaperonins - genetics Cholesterol CRISPR Cytoskeleton Endoplasmic reticulum Energy metabolism Energy Metabolism - genetics Gene expression Gene Knockout Techniques Gene sequencing Genetic modification Genome editing Glycogen Glycogen synthase kinase 3 Glycolysis Hepatoma HSP90 Heat-Shock Proteins Hsp90 protein Humans Kinases Life Sciences Lipid metabolism Lipid Metabolism - genetics Liver cancer Localization Metabolism Organelles - genetics Organelles - metabolism Original Original Article Proteins Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism Receptors, Steroid - genetics Ribonucleic acid RNA RNA, Messenger - genetics Signal Transduction - genetics Signaling Steroidogenesis Sterol regulatory element-binding protein Synthesis Transcription Transmission electron microscopy Triglycerides
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