Microbiome–metabolomics reveals gut microbiota associated with glycine-conjugated metabolites and polyamine metabolism in chronic kidney disease
Dysbiosis of the gut microbiome and related metabolites in chronic kidney disease (CKD) have been intimately associated with the prevalence of cardiovascular diseases. Unfortunately, thus far, there is a paucity of sufficient knowledge of gut microbiome and related metabolites on CKD progression par...
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| Veröffentlicht in: | Cellular and molecular life sciences : CMLS 2019-12, Vol.76 (24), p.4961-4978 |
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| creator | Feng, Ya-Long Cao, Gang Chen, Dan-Qian Vaziri, Nosratola D. Chen, Lin Zhang, Jun Wang, Ming Guo, Yan Zhao, Ying-Yong |
| description | Dysbiosis of the gut microbiome and related metabolites in chronic kidney disease (CKD) have been intimately associated with the prevalence of cardiovascular diseases. Unfortunately, thus far, there is a paucity of sufficient knowledge of gut microbiome and related metabolites on CKD progression partly due to the severely limited investigations. Using a 5/6 nephrectomized (NX) rat model, we carried out 16S rRNA sequence and untargeted metabolomic analyses to explore the relationship between colon’s microbiota and serum metabolites. Marked decline in microbial diversity and richness was accompanied by significant changes in 291 serum metabolites, which were mediated by altered enzymatic activities and dysregulations of lipids, amino acids, bile acids and polyamines metabolisms. Interestingly, CCr was directly associated with some microbial genera and polyamine metabolism. However, SBP was directly related to certain microbial genera and glycine-conjugated metabolites in CKD rats. Administration of poricoic acid A (PAA) and
Poria cocos
(PC) ameliorated microbial dysbiosis as well as attenuated hypertension and renal fibrosis. In addition, treatments with PAA and PC lowered serum levels of microbial-derived products including glycine-conjugated compounds and polyamine metabolites. Collectively, the present study confirmed the CKD-associated gut microbial dysbiosis and identified a novel dietary and therapeutic strategy to improve the gut microbial dysbiosis and the associated metabolomic disorders and retarded the progression of kidney disease in the rat model of CKD. |
| doi_str_mv | 10.1007/s00018-019-03155-9 |
| format | Article |
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Poria cocos
(PC) ameliorated microbial dysbiosis as well as attenuated hypertension and renal fibrosis. In addition, treatments with PAA and PC lowered serum levels of microbial-derived products including glycine-conjugated compounds and polyamine metabolites. Collectively, the present study confirmed the CKD-associated gut microbial dysbiosis and identified a novel dietary and therapeutic strategy to improve the gut microbial dysbiosis and the associated metabolomic disorders and retarded the progression of kidney disease in the rat model of CKD.</description><identifier>ISSN: 1420-682X</identifier><identifier>EISSN: 1420-9071</identifier><identifier>DOI: 10.1007/s00018-019-03155-9</identifier><identifier>PMID: 31147751</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Amino acids ; Animals ; Bile acids ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Cardiovascular diseases ; Cell Biology ; Colon ; Disease Models, Animal ; Dysbacteriosis ; Dysbiosis - genetics ; Dysbiosis - metabolism ; Dysbiosis - pathology ; Enzymatic activity ; Fibrosis ; Gastrointestinal Microbiome - genetics ; Glycine ; Glycine - metabolism ; Heart diseases ; Humans ; Hypertension ; Hypertension - genetics ; Hypertension - metabolism ; Hypertension - pathology ; Intestinal microflora ; Kidney diseases ; Kidneys ; Life Sciences ; Lipid metabolism ; Lipids ; Male ; Metabolism ; Metabolites ; Metabolome - genetics ; Metabolomics ; Metabolomics - methods ; Microbiomes ; Microbiota ; Microorganisms ; Original ; Original Article ; Polyamines ; Polyamines - metabolism ; Rats ; Renal Insufficiency, Chronic - metabolism ; Renal Insufficiency, Chronic - microbiology ; Renal Insufficiency, Chronic - pathology ; rRNA 16S ; Serum levels ; Triterpenes - pharmacology ; Wolfiporia - metabolism</subject><ispartof>Cellular and molecular life sciences : CMLS, 2019-12, Vol.76 (24), p.4961-4978</ispartof><rights>Springer Nature Switzerland AG 2019</rights><rights>Cellular and Molecular Life Sciences is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c475t-76ffd4286404fee42bf3860cc30b26db5ef69a032f25922a71e6c7b1b735ceb93</citedby><cites>FETCH-LOGICAL-c475t-76ffd4286404fee42bf3860cc30b26db5ef69a032f25922a71e6c7b1b735ceb93</cites><orcidid>0000-0002-0239-7342</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11105293/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11105293/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,724,777,781,882,27905,27906,41469,42538,51300,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31147751$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Feng, Ya-Long</creatorcontrib><creatorcontrib>Cao, Gang</creatorcontrib><creatorcontrib>Chen, Dan-Qian</creatorcontrib><creatorcontrib>Vaziri, Nosratola D.</creatorcontrib><creatorcontrib>Chen, Lin</creatorcontrib><creatorcontrib>Zhang, Jun</creatorcontrib><creatorcontrib>Wang, Ming</creatorcontrib><creatorcontrib>Guo, Yan</creatorcontrib><creatorcontrib>Zhao, Ying-Yong</creatorcontrib><title>Microbiome–metabolomics reveals gut microbiota associated with glycine-conjugated metabolites and polyamine metabolism in chronic kidney disease</title><title>Cellular and molecular life sciences : CMLS</title><addtitle>Cell. Mol. Life Sci</addtitle><addtitle>Cell Mol Life Sci</addtitle><description>Dysbiosis of the gut microbiome and related metabolites in chronic kidney disease (CKD) have been intimately associated with the prevalence of cardiovascular diseases. Unfortunately, thus far, there is a paucity of sufficient knowledge of gut microbiome and related metabolites on CKD progression partly due to the severely limited investigations. Using a 5/6 nephrectomized (NX) rat model, we carried out 16S rRNA sequence and untargeted metabolomic analyses to explore the relationship between colon’s microbiota and serum metabolites. Marked decline in microbial diversity and richness was accompanied by significant changes in 291 serum metabolites, which were mediated by altered enzymatic activities and dysregulations of lipids, amino acids, bile acids and polyamines metabolisms. Interestingly, CCr was directly associated with some microbial genera and polyamine metabolism. However, SBP was directly related to certain microbial genera and glycine-conjugated metabolites in CKD rats. Administration of poricoic acid A (PAA) and
Poria cocos
(PC) ameliorated microbial dysbiosis as well as attenuated hypertension and renal fibrosis. In addition, treatments with PAA and PC lowered serum levels of microbial-derived products including glycine-conjugated compounds and polyamine metabolites. Collectively, the present study confirmed the CKD-associated gut microbial dysbiosis and identified a novel dietary and therapeutic strategy to improve the gut microbial dysbiosis and the associated metabolomic disorders and retarded the progression of kidney disease in the rat model of CKD.</description><subject>Amino acids</subject><subject>Animals</subject><subject>Bile acids</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cardiovascular diseases</subject><subject>Cell Biology</subject><subject>Colon</subject><subject>Disease Models, Animal</subject><subject>Dysbacteriosis</subject><subject>Dysbiosis - genetics</subject><subject>Dysbiosis - metabolism</subject><subject>Dysbiosis - pathology</subject><subject>Enzymatic activity</subject><subject>Fibrosis</subject><subject>Gastrointestinal Microbiome - genetics</subject><subject>Glycine</subject><subject>Glycine - metabolism</subject><subject>Heart diseases</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypertension - genetics</subject><subject>Hypertension - metabolism</subject><subject>Hypertension - pathology</subject><subject>Intestinal microflora</subject><subject>Kidney diseases</subject><subject>Kidneys</subject><subject>Life Sciences</subject><subject>Lipid metabolism</subject><subject>Lipids</subject><subject>Male</subject><subject>Metabolism</subject><subject>Metabolites</subject><subject>Metabolome - genetics</subject><subject>Metabolomics</subject><subject>Metabolomics - methods</subject><subject>Microbiomes</subject><subject>Microbiota</subject><subject>Microorganisms</subject><subject>Original</subject><subject>Original Article</subject><subject>Polyamines</subject><subject>Polyamines - metabolism</subject><subject>Rats</subject><subject>Renal Insufficiency, Chronic - metabolism</subject><subject>Renal Insufficiency, Chronic - microbiology</subject><subject>Renal Insufficiency, Chronic - pathology</subject><subject>rRNA 16S</subject><subject>Serum levels</subject><subject>Triterpenes - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cellular and molecular life sciences : CMLS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Feng, Ya-Long</au><au>Cao, Gang</au><au>Chen, Dan-Qian</au><au>Vaziri, Nosratola D.</au><au>Chen, Lin</au><au>Zhang, Jun</au><au>Wang, Ming</au><au>Guo, Yan</au><au>Zhao, Ying-Yong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Microbiome–metabolomics reveals gut microbiota associated with glycine-conjugated metabolites and polyamine metabolism in chronic kidney disease</atitle><jtitle>Cellular and molecular life sciences : CMLS</jtitle><stitle>Cell. Mol. Life Sci</stitle><addtitle>Cell Mol Life Sci</addtitle><date>2019-12-01</date><risdate>2019</risdate><volume>76</volume><issue>24</issue><spage>4961</spage><epage>4978</epage><pages>4961-4978</pages><issn>1420-682X</issn><eissn>1420-9071</eissn><abstract>Dysbiosis of the gut microbiome and related metabolites in chronic kidney disease (CKD) have been intimately associated with the prevalence of cardiovascular diseases. Unfortunately, thus far, there is a paucity of sufficient knowledge of gut microbiome and related metabolites on CKD progression partly due to the severely limited investigations. Using a 5/6 nephrectomized (NX) rat model, we carried out 16S rRNA sequence and untargeted metabolomic analyses to explore the relationship between colon’s microbiota and serum metabolites. Marked decline in microbial diversity and richness was accompanied by significant changes in 291 serum metabolites, which were mediated by altered enzymatic activities and dysregulations of lipids, amino acids, bile acids and polyamines metabolisms. Interestingly, CCr was directly associated with some microbial genera and polyamine metabolism. However, SBP was directly related to certain microbial genera and glycine-conjugated metabolites in CKD rats. Administration of poricoic acid A (PAA) and
Poria cocos
(PC) ameliorated microbial dysbiosis as well as attenuated hypertension and renal fibrosis. In addition, treatments with PAA and PC lowered serum levels of microbial-derived products including glycine-conjugated compounds and polyamine metabolites. Collectively, the present study confirmed the CKD-associated gut microbial dysbiosis and identified a novel dietary and therapeutic strategy to improve the gut microbial dysbiosis and the associated metabolomic disorders and retarded the progression of kidney disease in the rat model of CKD.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>31147751</pmid><doi>10.1007/s00018-019-03155-9</doi><tpages>18</tpages><orcidid>https://orcid.org/0000-0002-0239-7342</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Amino acids Animals Bile acids Biochemistry Biomedical and Life Sciences Biomedicine Cardiovascular diseases Cell Biology Colon Disease Models, Animal Dysbacteriosis Dysbiosis - genetics Dysbiosis - metabolism Dysbiosis - pathology Enzymatic activity Fibrosis Gastrointestinal Microbiome - genetics Glycine Glycine - metabolism Heart diseases Humans Hypertension Hypertension - genetics Hypertension - metabolism Hypertension - pathology Intestinal microflora Kidney diseases Kidneys Life Sciences Lipid metabolism Lipids Male Metabolism Metabolites Metabolome - genetics Metabolomics Metabolomics - methods Microbiomes Microbiota Microorganisms Original Original Article Polyamines Polyamines - metabolism Rats Renal Insufficiency, Chronic - metabolism Renal Insufficiency, Chronic - microbiology Renal Insufficiency, Chronic - pathology rRNA 16S Serum levels Triterpenes - pharmacology Wolfiporia - metabolism |
| title | Microbiome–metabolomics reveals gut microbiota associated with glycine-conjugated metabolites and polyamine metabolism in chronic kidney disease |
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