Sorting nexin 3 mutation impairs development and neuronal function in Caenorhabditis elegans

The sorting nexins family of proteins (SNXs) plays pleiotropic functions in protein trafficking and intracellular signaling and has been associated with several disorders, namely Alzheimer's disease and Down's syndrome. Despite the growing association of SNXs with neurodegeneration, not mu...

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Veröffentlicht in:	Cellular and molecular life sciences : CMLS 2018-06, Vol.75 (11), p.2027-2044
Hauptverfasser:	Vieira, Neide, Bessa, Carlos, Rodrigues, Ana J., Marques, Paulo, Chan, Fung-Yi, Carvalho, Ana Xavier de, Neves, Margarida Correia, Sousa, Nuno
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohols Animals Behavior Biochemistry Biomedical and Life Sciences Biomedicine Body length Body Size Caenorhabditis elegans Caenorhabditis elegans - genetics Caenorhabditis elegans - growth & development Caenorhabditis elegans - physiology Caenorhabditis elegans Proteins - genetics Cell Biology Chemotaxis Defects Deletion mutant Gene Deletion Gene Expression Regulation, Developmental Genomes Hatching Impaired development Intracellular signalling Isopentyl alcohol Life Sciences Life span Locomotion Longevity Mutation Nematodes Nervous system Nervous System - growth & development Nervous System - metabolism Nervous System Physiological Phenomena Neurodegeneration Neuronal defects Neurons Neurons - metabolism Neurons - pathology Nexin Original Original Article Osmotic Pressure Oxidative Stress Phylogeny Point mutation Protein transport Proteins Science & Technology Secretion Sorting nexins Sorting Nexins - genetics Wiring Wnt protein γ-Aminobutyric acid
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