Comparison of two formulations of buprenorphine in cats administered by the oral transmucosal route
This randomised, blinded, cross-over study investigated the ease of oral transmucosal administration of two formulations of buprenorphine using glucose as a control in 12 cats. The cats received three treatments: buprenorphine multi-dose, buprenorphine and the equivalent volume of glucose 5%. Ease o...
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| Veröffentlicht in: | Journal of feline medicine and surgery 2012-08, Vol.14 (8), p.534-539 |
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| creator | Bortolami, Elisa Slingsby, Louisa Love, Emma J |
| description | This randomised, blinded, cross-over study investigated the ease of oral transmucosal administration of two formulations of buprenorphine using glucose as a control in 12 cats. The cats received three treatments: buprenorphine multi-dose, buprenorphine and the equivalent volume of glucose 5%. Ease of treatment administration, observation of swallowing, changes in pupil size, sedation, salivation, vomiting, behaviour and food intake were assessed. The data were analysed using MLwiN and multi-level modelling. Ease of administration of buprenorphine multi-dose was statistically different from glucose (P 0.05). Mydriasis was evident after the administration of both formulations of buprenorphine. Sedation, salivation, vomiting, behavioural changes or in-appetence were not observed after any treatment. Cats tolerated oral transmucosal administration of glucose better than buprenorphine multi-dose, while buprenorphine administration was tolerated as well as glucose. |
| doi_str_mv | 10.1177/1098612X12442038 |
| format | Article |
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The cats received three treatments: buprenorphine multi-dose, buprenorphine and the equivalent volume of glucose 5%. Ease of treatment administration, observation of swallowing, changes in pupil size, sedation, salivation, vomiting, behaviour and food intake were assessed. The data were analysed using MLwiN and multi-level modelling. Ease of administration of buprenorphine multi-dose was statistically different from glucose (P <0.001), and the administration of all treatments became easier over the study periods. Swallowing was not statistically different between groups (P >0.05). Mydriasis was evident after the administration of both formulations of buprenorphine. Sedation, salivation, vomiting, behavioural changes or in-appetence were not observed after any treatment. Cats tolerated oral transmucosal administration of glucose better than buprenorphine multi-dose, while buprenorphine administration was tolerated as well as glucose.</description><identifier>ISSN: 1098-612X</identifier><identifier>ISSN: 1532-2750</identifier><identifier>EISSN: 1532-2750</identifier><identifier>DOI: 10.1177/1098612X12442038</identifier><identifier>PMID: 22403414</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Administration, Buccal ; Analgesics, Opioid - administration & dosage ; Analgesics, Opioid - chemistry ; Analgesics, Opioid - pharmacokinetics ; Animals ; Buprenorphine - administration & dosage ; Buprenorphine - chemistry ; Buprenorphine - pharmacokinetics ; Cat Diseases - drug therapy ; Cats - surgery ; Chemistry, Pharmaceutical ; Cross-Over Studies ; Dose-Response Relationship, Drug ; Drug Therapy, Combination ; Glucose - administration & dosage ; Hemodynamics - drug effects ; Intestinal Absorption ; Original</subject><ispartof>Journal of feline medicine and surgery, 2012-08, Vol.14 (8), p.534-539</ispartof><rights>ISFM and AAFP 2012</rights><rights>ISFM and AAFP 2012 2012 International Society of Feline Medicine and American Association of Feline Practitioners</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c393t-c0239280712f34a5ccded7f6d95ac67a293fb4b30005ba8df47f48295b59a5fb3</citedby><cites>FETCH-LOGICAL-c393t-c0239280712f34a5ccded7f6d95ac67a293fb4b30005ba8df47f48295b59a5fb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11104194/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11104194/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,21966,27853,27924,27925,44945,45333,53791,53793</link.rule.ids><linktorsrc>$$Uhttps://journals.sagepub.com/doi/full/10.1177/1098612X12442038?utm_source=summon&utm_medium=discovery-provider$$EView_record_in_SAGE_Publications$$FView_record_in_$$GSAGE_Publications</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22403414$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bortolami, Elisa</creatorcontrib><creatorcontrib>Slingsby, Louisa</creatorcontrib><creatorcontrib>Love, Emma J</creatorcontrib><title>Comparison of two formulations of buprenorphine in cats administered by the oral transmucosal route</title><title>Journal of feline medicine and surgery</title><addtitle>J Feline Med Surg</addtitle><description>This randomised, blinded, cross-over study investigated the ease of oral transmucosal administration of two formulations of buprenorphine using glucose as a control in 12 cats. The cats received three treatments: buprenorphine multi-dose, buprenorphine and the equivalent volume of glucose 5%. Ease of treatment administration, observation of swallowing, changes in pupil size, sedation, salivation, vomiting, behaviour and food intake were assessed. The data were analysed using MLwiN and multi-level modelling. Ease of administration of buprenorphine multi-dose was statistically different from glucose (P <0.001), and the administration of all treatments became easier over the study periods. Swallowing was not statistically different between groups (P >0.05). Mydriasis was evident after the administration of both formulations of buprenorphine. Sedation, salivation, vomiting, behavioural changes or in-appetence were not observed after any treatment. Cats tolerated oral transmucosal administration of glucose better than buprenorphine multi-dose, while buprenorphine administration was tolerated as well as glucose.</description><subject>Administration, Buccal</subject><subject>Analgesics, Opioid - administration & dosage</subject><subject>Analgesics, Opioid - chemistry</subject><subject>Analgesics, Opioid - pharmacokinetics</subject><subject>Animals</subject><subject>Buprenorphine - administration & dosage</subject><subject>Buprenorphine - chemistry</subject><subject>Buprenorphine - pharmacokinetics</subject><subject>Cat Diseases - drug therapy</subject><subject>Cats - surgery</subject><subject>Chemistry, Pharmaceutical</subject><subject>Cross-Over Studies</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug Therapy, Combination</subject><subject>Glucose - administration & dosage</subject><subject>Hemodynamics - drug effects</subject><subject>Intestinal Absorption</subject><subject>Original</subject><issn>1098-612X</issn><issn>1532-2750</issn><issn>1532-2750</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1UU1PxCAUJEaj68fdk-HopcpXt-VkzMavZBMvmngjlMIupoUKVLP_Xja7GjXxxIOZN294A8ApRhcYV9UlRryeYvKCCWME0XoHTHBJSUGqEu3mOsPFGj8AhzG-IoQ45WQfHBDCEGWYTYCa-X6QwUbvoDcwfXhofOjHTibrXVy_NeMQtPNhWFqnoXVQyRShbHvrbEw66BY2K5iWGvogO5iCdLEflY_5EvyY9DHYM7KL-mR7HoHn25un2X0xf7x7mF3PC0U5TYVCJLurUYWJoUyWSrW6rcy05aVU00oSTk3DGpq_UTaybg2rDKsJL5uSy9I09AhcbXSHsel1q7TLXjoxBNvLsBJeWvEbcXYpFv5dYIwRw5xlhfOtQvBvo45J9DYq3XXSaT9GgRGpMnPK1lS0oargYwzafM_BSKzDEX_DyS1nP_19N3ylkQnFhhDlQotXPwaX9_W_4Cd5rZn7</recordid><startdate>20120801</startdate><enddate>20120801</enddate><creator>Bortolami, Elisa</creator><creator>Slingsby, Louisa</creator><creator>Love, Emma J</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20120801</creationdate><title>Comparison of two formulations of buprenorphine in cats administered by the oral transmucosal route</title><author>Bortolami, Elisa ; Slingsby, Louisa ; Love, Emma J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c393t-c0239280712f34a5ccded7f6d95ac67a293fb4b30005ba8df47f48295b59a5fb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Administration, Buccal</topic><topic>Analgesics, Opioid - administration & dosage</topic><topic>Analgesics, Opioid - chemistry</topic><topic>Analgesics, Opioid - pharmacokinetics</topic><topic>Animals</topic><topic>Buprenorphine - administration & dosage</topic><topic>Buprenorphine - chemistry</topic><topic>Buprenorphine - pharmacokinetics</topic><topic>Cat Diseases - drug therapy</topic><topic>Cats - surgery</topic><topic>Chemistry, Pharmaceutical</topic><topic>Cross-Over Studies</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug Therapy, Combination</topic><topic>Glucose - administration & dosage</topic><topic>Hemodynamics - drug effects</topic><topic>Intestinal Absorption</topic><topic>Original</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bortolami, Elisa</creatorcontrib><creatorcontrib>Slingsby, Louisa</creatorcontrib><creatorcontrib>Love, Emma J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of feline medicine and surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Bortolami, Elisa</au><au>Slingsby, Louisa</au><au>Love, Emma J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of two formulations of buprenorphine in cats administered by the oral transmucosal route</atitle><jtitle>Journal of feline medicine and surgery</jtitle><addtitle>J Feline Med Surg</addtitle><date>2012-08-01</date><risdate>2012</risdate><volume>14</volume><issue>8</issue><spage>534</spage><epage>539</epage><pages>534-539</pages><issn>1098-612X</issn><issn>1532-2750</issn><eissn>1532-2750</eissn><abstract>This randomised, blinded, cross-over study investigated the ease of oral transmucosal administration of two formulations of buprenorphine using glucose as a control in 12 cats. The cats received three treatments: buprenorphine multi-dose, buprenorphine and the equivalent volume of glucose 5%. Ease of treatment administration, observation of swallowing, changes in pupil size, sedation, salivation, vomiting, behaviour and food intake were assessed. The data were analysed using MLwiN and multi-level modelling. Ease of administration of buprenorphine multi-dose was statistically different from glucose (P <0.001), and the administration of all treatments became easier over the study periods. Swallowing was not statistically different between groups (P >0.05). Mydriasis was evident after the administration of both formulations of buprenorphine. Sedation, salivation, vomiting, behavioural changes or in-appetence were not observed after any treatment. Cats tolerated oral transmucosal administration of glucose better than buprenorphine multi-dose, while buprenorphine administration was tolerated as well as glucose.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>22403414</pmid><doi>10.1177/1098612X12442038</doi><tpages>6</tpages></addata></record> |
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| ispartof | Journal of feline medicine and surgery, 2012-08, Vol.14 (8), p.534-539 |
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| source | Sage Journals GOLD Open Access 2024 |
| subjects | Administration, Buccal Analgesics, Opioid - administration & dosage Analgesics, Opioid - chemistry Analgesics, Opioid - pharmacokinetics Animals Buprenorphine - administration & dosage Buprenorphine - chemistry Buprenorphine - pharmacokinetics Cat Diseases - drug therapy Cats - surgery Chemistry, Pharmaceutical Cross-Over Studies Dose-Response Relationship, Drug Drug Therapy, Combination Glucose - administration & dosage Hemodynamics - drug effects Intestinal Absorption Original |
| title | Comparison of two formulations of buprenorphine in cats administered by the oral transmucosal route |
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