Analgesia after feline ovariohysterectomy under midazolam-medetomidine-ketamine anaesthesia with buprenorphine or butorphanol, and carprofen or meloxicam: a prospective, randomised clinical trial
One hundred female cats undergoing routine ovariohysterectomy under midazolam-medetomidine-ketamine anaesthesia were included in a blinded, randomised, prospective clinical study to compare postoperative analgesia produced by four analgesic drug combinations given preoperatively (n = 25 per group)....
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| Veröffentlicht in: | Journal of feline medicine and surgery 2012-08, Vol.14 (8), p.553-559 |
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| description | One hundred female cats undergoing routine ovariohysterectomy under midazolam-medetomidine-ketamine anaesthesia were included in a blinded, randomised, prospective clinical study to compare postoperative analgesia produced by four analgesic drug combinations given preoperatively (n = 25 per group). A secondary aim was to assess the effects in kittens and pregnant animals. Buprenorphine 180 µg/m2 or butorphanol 6 mg/m2 were given with either carprofen 4 mg/kg (groups BUPC and BUTC, respectively) or meloxicam 0.3 mg/kg (groups BUPM or BUTM, respectively). Medetomidine was not antagonised. A simple, descriptive scale (SDS; 0–4), a dynamic and interactive visual analogue scale (DIVAS; 0–100 mm) and mechanical nociceptive thresholds (MT; 2.5-mm diameter probe) were used to evaluate postoperative pain. All pain scores were low (DIVAS |
| doi_str_mv | 10.1177/1098612X12444743 |
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A secondary aim was to assess the effects in kittens and pregnant animals. Buprenorphine 180 µg/m2 or butorphanol 6 mg/m2 were given with either carprofen 4 mg/kg (groups BUPC and BUTC, respectively) or meloxicam 0.3 mg/kg (groups BUPM or BUTM, respectively). Medetomidine was not antagonised. A simple, descriptive scale (SDS; 0–4), a dynamic and interactive visual analogue scale (DIVAS; 0–100 mm) and mechanical nociceptive thresholds (MT; 2.5-mm diameter probe) were used to evaluate postoperative pain. All pain scores were low (DIVAS <10 mm, SDS <2 and MT >10 N) and there were no significant differences between the groups. It was concluded that all protocols provided adequate analgesia and when used with midazolam-medetomidine-ketamine are effective for routine feline ovariohysterectomy.</description><identifier>ISSN: 1098-612X</identifier><identifier>ISSN: 1532-2750</identifier><identifier>EISSN: 1532-2750</identifier><identifier>DOI: 10.1177/1098612X12444743</identifier><identifier>PMID: 22505603</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject><![CDATA[analgesia ; Analgesics, Opioid - administration & dosage ; anesthesia ; Anesthesia, Obstetrical - veterinary ; Anesthetics, Combined - administration & dosage ; Animals ; Behavior, Animal - drug effects ; buprenorphine ; Buprenorphine - administration & dosage ; butorphanol ; Carbazoles - administration & dosage ; Cat Diseases - prevention & control ; Cats ; clinical trials ; Double-Blind Method ; Female ; females ; Humans ; Hysterectomy - veterinary ; medetomidine ; medicine ; Meloxicam ; Original ; Ovariectomy - veterinary ; pain ; Pain, Postoperative - prevention & control ; Pain, Postoperative - veterinary ; Postoperative Care - veterinary ; Pregnancy ; Premedication ; Prenatal Exposure Delayed Effects - veterinary ; Prospective Studies ; spaying ; Thiazines - administration & dosage ; Thiazoles - administration & dosage ; Time Factors ; Treatment Outcome]]></subject><ispartof>Journal of feline medicine and surgery, 2012-08, Vol.14 (8), p.553-559</ispartof><rights>ISFM and AAFP 2012</rights><rights>ISFM and AAFP 2012 2012 International Society of Feline Medicine and American Association of Feline Practitioners</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c494t-1b800ef33d661176e6a733a165760c20cca586720257658c0260463e917793183</citedby><cites>FETCH-LOGICAL-c494t-1b800ef33d661176e6a733a165760c20cca586720257658c0260463e917793183</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11104192/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11104192/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,21945,27830,27901,27902,44921,45309,53766,53768</link.rule.ids><linktorsrc>$$Uhttps://journals.sagepub.com/doi/full/10.1177/1098612X12444743?utm_source=summon&utm_medium=discovery-provider$$EView_record_in_SAGE_Publications$$FView_record_in_$$GSAGE_Publications</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22505603$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Polson, Sally</creatorcontrib><creatorcontrib>Taylor, Polly M</creatorcontrib><creatorcontrib>Yates, David</creatorcontrib><title>Analgesia after feline ovariohysterectomy under midazolam-medetomidine-ketamine anaesthesia with buprenorphine or butorphanol, and carprofen or meloxicam: a prospective, randomised clinical trial</title><title>Journal of feline medicine and surgery</title><addtitle>J Feline Med Surg</addtitle><description>One hundred female cats undergoing routine ovariohysterectomy under midazolam-medetomidine-ketamine anaesthesia were included in a blinded, randomised, prospective clinical study to compare postoperative analgesia produced by four analgesic drug combinations given preoperatively (n = 25 per group). 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It was concluded that all protocols provided adequate analgesia and when used with midazolam-medetomidine-ketamine are effective for routine feline ovariohysterectomy.</description><subject>analgesia</subject><subject>Analgesics, Opioid - administration & dosage</subject><subject>anesthesia</subject><subject>Anesthesia, Obstetrical - veterinary</subject><subject>Anesthetics, Combined - administration & dosage</subject><subject>Animals</subject><subject>Behavior, Animal - drug effects</subject><subject>buprenorphine</subject><subject>Buprenorphine - administration & dosage</subject><subject>butorphanol</subject><subject>Carbazoles - administration & dosage</subject><subject>Cat Diseases - prevention & control</subject><subject>Cats</subject><subject>clinical trials</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>females</subject><subject>Humans</subject><subject>Hysterectomy - veterinary</subject><subject>medetomidine</subject><subject>medicine</subject><subject>Meloxicam</subject><subject>Original</subject><subject>Ovariectomy - veterinary</subject><subject>pain</subject><subject>Pain, Postoperative - prevention & control</subject><subject>Pain, Postoperative - veterinary</subject><subject>Postoperative Care - veterinary</subject><subject>Pregnancy</subject><subject>Premedication</subject><subject>Prenatal Exposure Delayed Effects - veterinary</subject><subject>Prospective Studies</subject><subject>spaying</subject><subject>Thiazines - administration & dosage</subject><subject>Thiazoles - administration & dosage</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><issn>1098-612X</issn><issn>1532-2750</issn><issn>1532-2750</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFksFu1DAQhiMEoqVw54Ry5NDA2E7shAuqKgpIlbiAxC2adSa7Lk4c7GRheb2-GLPdUgES4mR7_m_-8Ywmy54KeCGEMS8FNLUW8rOQZVmaUt3LjkWlZCFNBff5znKx14-yRyldAUCjGvkwO5KygkqDOs6uz0b0a0oOc-xninlP3o2Uhy1GFza7xDGycxh2-TJ2rA-uwx_B41AM1BELrmO--EIzDvtEHJHSvLlx_ObmTb5apkhjiNPmxjdyYN6_cAz-lPEutxinGHoa9-pAPnx3FodXOeYcThOXd1s6zSOzXC4RZ_AfmfH5HB36x9mDHn2iJ7fnSfbp4s3H83fF5Ye378_PLgtbNuVciFUNQL1SndY8PU0ajVIodGU0WAnWYlVrI0FyoKotSA2lVtTwpBslanWSvT74TsuKm7c0zhF9O0U3YNy1AV37pzK6TbsO21YIAaVoJDs8v3WI4evCc2q5H0ve40hhSa2UEuqyNgr-iwqQhk0NGEbhgFoeV4rU331JQLvfk_bvPeGUZ7-3cpfwazEYKA5AwjW1V2GJvCfp34Y_Actxyp0</recordid><startdate>20120801</startdate><enddate>20120801</enddate><creator>Polson, Sally</creator><creator>Taylor, Polly M</creator><creator>Yates, David</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope></search><sort><creationdate>20120801</creationdate><title>Analgesia after feline ovariohysterectomy under midazolam-medetomidine-ketamine anaesthesia with buprenorphine or butorphanol, and carprofen or meloxicam: a prospective, randomised clinical trial</title><author>Polson, Sally ; Taylor, Polly M ; Yates, David</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c494t-1b800ef33d661176e6a733a165760c20cca586720257658c0260463e917793183</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>analgesia</topic><topic>Analgesics, Opioid - administration & dosage</topic><topic>anesthesia</topic><topic>Anesthesia, Obstetrical - veterinary</topic><topic>Anesthetics, Combined - administration & dosage</topic><topic>Animals</topic><topic>Behavior, Animal - drug effects</topic><topic>buprenorphine</topic><topic>Buprenorphine - administration & dosage</topic><topic>butorphanol</topic><topic>Carbazoles - administration & dosage</topic><topic>Cat Diseases - prevention & control</topic><topic>Cats</topic><topic>clinical trials</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>females</topic><topic>Humans</topic><topic>Hysterectomy - veterinary</topic><topic>medetomidine</topic><topic>medicine</topic><topic>Meloxicam</topic><topic>Original</topic><topic>Ovariectomy - veterinary</topic><topic>pain</topic><topic>Pain, Postoperative - prevention & control</topic><topic>Pain, Postoperative - veterinary</topic><topic>Postoperative Care - veterinary</topic><topic>Pregnancy</topic><topic>Premedication</topic><topic>Prenatal Exposure Delayed Effects - veterinary</topic><topic>Prospective Studies</topic><topic>spaying</topic><topic>Thiazines - administration & dosage</topic><topic>Thiazoles - administration & dosage</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Polson, Sally</creatorcontrib><creatorcontrib>Taylor, Polly M</creatorcontrib><creatorcontrib>Yates, David</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of feline medicine and surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Polson, Sally</au><au>Taylor, Polly M</au><au>Yates, David</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Analgesia after feline ovariohysterectomy under midazolam-medetomidine-ketamine anaesthesia with buprenorphine or butorphanol, and carprofen or meloxicam: a prospective, randomised clinical trial</atitle><jtitle>Journal of feline medicine and surgery</jtitle><addtitle>J Feline Med Surg</addtitle><date>2012-08-01</date><risdate>2012</risdate><volume>14</volume><issue>8</issue><spage>553</spage><epage>559</epage><pages>553-559</pages><issn>1098-612X</issn><issn>1532-2750</issn><eissn>1532-2750</eissn><abstract>One hundred female cats undergoing routine ovariohysterectomy under midazolam-medetomidine-ketamine anaesthesia were included in a blinded, randomised, prospective clinical study to compare postoperative analgesia produced by four analgesic drug combinations given preoperatively (n = 25 per group). A secondary aim was to assess the effects in kittens and pregnant animals. Buprenorphine 180 µg/m2 or butorphanol 6 mg/m2 were given with either carprofen 4 mg/kg (groups BUPC and BUTC, respectively) or meloxicam 0.3 mg/kg (groups BUPM or BUTM, respectively). Medetomidine was not antagonised. A simple, descriptive scale (SDS; 0–4), a dynamic and interactive visual analogue scale (DIVAS; 0–100 mm) and mechanical nociceptive thresholds (MT; 2.5-mm diameter probe) were used to evaluate postoperative pain. All pain scores were low (DIVAS <10 mm, SDS <2 and MT >10 N) and there were no significant differences between the groups. It was concluded that all protocols provided adequate analgesia and when used with midazolam-medetomidine-ketamine are effective for routine feline ovariohysterectomy.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>22505603</pmid><doi>10.1177/1098612X12444743</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of feline medicine and surgery, 2012-08, Vol.14 (8), p.553-559 |
| issn | 1098-612X 1532-2750 1532-2750 |
| language | eng |
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| source | SAGE Open Access Journals |
| subjects | analgesia Analgesics, Opioid - administration & dosage anesthesia Anesthesia, Obstetrical - veterinary Anesthetics, Combined - administration & dosage Animals Behavior, Animal - drug effects buprenorphine Buprenorphine - administration & dosage butorphanol Carbazoles - administration & dosage Cat Diseases - prevention & control Cats clinical trials Double-Blind Method Female females Humans Hysterectomy - veterinary medetomidine medicine Meloxicam Original Ovariectomy - veterinary pain Pain, Postoperative - prevention & control Pain, Postoperative - veterinary Postoperative Care - veterinary Pregnancy Premedication Prenatal Exposure Delayed Effects - veterinary Prospective Studies spaying Thiazines - administration & dosage Thiazoles - administration & dosage Time Factors Treatment Outcome |
| title | Analgesia after feline ovariohysterectomy under midazolam-medetomidine-ketamine anaesthesia with buprenorphine or butorphanol, and carprofen or meloxicam: a prospective, randomised clinical trial |
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