Assessment of Native Myocardial T1 Mapping for Early Detection of Anthracycline-Induced Cardiotoxicity in Patients with Cancer: a Systematic Review and Meta-analysis
Anthracycline antibiotic is one of the most effective anti-tumor drugs used to manage certain types of breast cancers, lymphomas, and leukemias. However, anthracyclines induce a dose-dependent cardiotoxicity that may progress to heart failure. Thus, using a sensitive predictor of early cardiac dysfu...
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| Veröffentlicht in: | Cardiovascular toxicology 2024-06, Vol.24 (6), p.563-575 |
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| creator | Mohamed, Amira A. Elmancy, Layla Y. Abulola, Sara M. Al-Qattan, Sara A. Mohamed Ibrahim, Mohamed Izham Maayah, Zaid H. |
| description | Anthracycline antibiotic is one of the most effective anti-tumor drugs used to manage certain types of breast cancers, lymphomas, and leukemias. However, anthracyclines induce a dose-dependent cardiotoxicity that may progress to heart failure. Thus, using a sensitive predictor of early cardiac dysfunction in patients treated with anthracyclines can help detect subclinical cardiac dysfunction early and help initiate interventions to protect these patients. Among parameters of myocardial measure, cardiac magnetic resonance (CMR)-measured native myocardial T1 mapping is considered a sensitive and accurate quantitative measure of early subclinical cardiac changes, particularly cardiac inflammation and fibrosis. However, to understand the quality and the validity of the current evidence supporting the use of these measures in patients treated with anthracyclines, we aimed to conduct a systematic review of clinical studies of this measure to detect early myocardial changes in cancer patients treated with anthracyclines. The primary outcome was the level of native T1 mapping. We performed fixed-effects meta-analyses and assessed certainty in effect estimates. Of the 1780 publications reviewed (till 2022), 23 were retrieved, and 9 articles met the inclusion criteria. Our study showed that exposure to anthracycline was associated with a significant elevation of native myocardial T1 mapping from baseline (95% CI 0.1121 to 0.5802;
p
= 0.0037) as well as compared to healthy control patients (95% CI 0.2925 to 0.7448;
p
|
| doi_str_mv | 10.1007/s12012-024-09866-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11102375</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3050937867</sourcerecordid><originalsourceid>FETCH-LOGICAL-c426t-756c818dee47531cd6c9c7eb7e564ff4fb3323ec9e4c580acbde73932ac96f23</originalsourceid><addsrcrecordid>eNp9UstuEzEUHSEQbQM_wAJZYsNmwI-xZ8wGRaFApQYQZG85njuJqxk72J6U-aD-J05TymPBypbP6175FMUzgl8RjOvXkVBMaIlpVWLZCFGSB8Up4VzmJy4fHu4Ml7XE_KQ4i_EKY0qp4I-LE9bUGAvBT4ubeYwQ4wAuId-hTzrZPaDl5I0OrdU9WhG01LuddRvU-YDOdegn9A4SmGS9O2jmLm2DNpPprYPywrWjgRYtDnqf_A9rbJqQdehL9s4xEV3btM24MxDeII2-TTHBkEGDvsLewjXSrkVLSLrUTvdTtPFJ8ajTfYSnd-esWL0_Xy0-lpefP1ws5pelqahIZc2FaUjTAlQ1Z8S0wkhTw7oGLqquq7o1Y5SBkVAZ3mBt1i3UTDKqjRQdZbPi7dF2N64HaE2eNuhe7YIddJiU11b9jTi7VRu_V4QQTFnOnBUv7xyC_z5CTGqw0UDfawd-jIphjiWrG1Fn6ot_qFd-DHnhW5agXEgqMoseWSb4GAN099MQrA4tUMcWqNwCddsCRbLo-Z973Et-fXsmsCMhZshtIPzO_o_tT-jjwQQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3056256926</pqid></control><display><type>article</type><title>Assessment of Native Myocardial T1 Mapping for Early Detection of Anthracycline-Induced Cardiotoxicity in Patients with Cancer: a Systematic Review and Meta-analysis</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Mohamed, Amira A. ; Elmancy, Layla Y. ; Abulola, Sara M. ; Al-Qattan, Sara A. ; Mohamed Ibrahim, Mohamed Izham ; Maayah, Zaid H.</creator><creatorcontrib>Mohamed, Amira A. ; Elmancy, Layla Y. ; Abulola, Sara M. ; Al-Qattan, Sara A. ; Mohamed Ibrahim, Mohamed Izham ; Maayah, Zaid H.</creatorcontrib><description>Anthracycline antibiotic is one of the most effective anti-tumor drugs used to manage certain types of breast cancers, lymphomas, and leukemias. However, anthracyclines induce a dose-dependent cardiotoxicity that may progress to heart failure. Thus, using a sensitive predictor of early cardiac dysfunction in patients treated with anthracyclines can help detect subclinical cardiac dysfunction early and help initiate interventions to protect these patients. Among parameters of myocardial measure, cardiac magnetic resonance (CMR)-measured native myocardial T1 mapping is considered a sensitive and accurate quantitative measure of early subclinical cardiac changes, particularly cardiac inflammation and fibrosis. However, to understand the quality and the validity of the current evidence supporting the use of these measures in patients treated with anthracyclines, we aimed to conduct a systematic review of clinical studies of this measure to detect early myocardial changes in cancer patients treated with anthracyclines. The primary outcome was the level of native T1 mapping. We performed fixed-effects meta-analyses and assessed certainty in effect estimates. Of the 1780 publications reviewed (till 2022), 23 were retrieved, and 9 articles met the inclusion criteria. Our study showed that exposure to anthracycline was associated with a significant elevation of native myocardial T1 mapping from baseline (95% CI 0.1121 to 0.5802;
p
= 0.0037) as well as compared to healthy control patients (95% CI 0.2925 to 0.7448;
p
< 0.0001). No significant publication bias was noted on the assessment of the funnel plot and Egger’s test. According to the
Q
test, there was no significant heterogeneity in the included studies (
I
2
= 0.0000% versus healthy controls and
I
2
= 14.0666% versus baseline). Overall, our study suggests that native myocardial T1 mapping is useful for detecting anthracycline-induced cardiotoxicity in patients with cancer.</description><identifier>ISSN: 1530-7905</identifier><identifier>ISSN: 1559-0259</identifier><identifier>EISSN: 1559-0259</identifier><identifier>DOI: 10.1007/s12012-024-09866-1</identifier><identifier>PMID: 38700665</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Adult ; Aged ; Anthracycline ; Anthracyclines - adverse effects ; Antibiotics, Antineoplastic - adverse effects ; Biomedical and Life Sciences ; Biomedicine ; Cancer ; Cardiology ; Cardiotoxicity ; Congestive heart failure ; Early Diagnosis ; Female ; Fibrosis ; Heart Diseases - chemically induced ; Heart Diseases - diagnosis ; Heart Diseases - diagnostic imaging ; Heart Diseases - physiopathology ; Heterogeneity ; Humans ; Leukemia ; Lymphoma ; Magnetic resonance ; Magnetic Resonance Imaging ; Male ; Mapping ; Meta-analysis ; Middle Aged ; Neoplasms - drug therapy ; Pharmacology/Toxicology ; Predictive Value of Tests ; Risk Assessment ; Risk Factors ; Systematic review ; Ventricular Function, Left - drug effects ; Young Adult</subject><ispartof>Cardiovascular toxicology, 2024-06, Vol.24 (6), p.563-575</ispartof><rights>The Author(s) 2024</rights><rights>2024. The Author(s).</rights><rights>Copyright Springer Nature B.V. Jun 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c426t-756c818dee47531cd6c9c7eb7e564ff4fb3323ec9e4c580acbde73932ac96f23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12012-024-09866-1$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12012-024-09866-1$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,778,782,883,27907,27908,41471,42540,51302</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38700665$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mohamed, Amira A.</creatorcontrib><creatorcontrib>Elmancy, Layla Y.</creatorcontrib><creatorcontrib>Abulola, Sara M.</creatorcontrib><creatorcontrib>Al-Qattan, Sara A.</creatorcontrib><creatorcontrib>Mohamed Ibrahim, Mohamed Izham</creatorcontrib><creatorcontrib>Maayah, Zaid H.</creatorcontrib><title>Assessment of Native Myocardial T1 Mapping for Early Detection of Anthracycline-Induced Cardiotoxicity in Patients with Cancer: a Systematic Review and Meta-analysis</title><title>Cardiovascular toxicology</title><addtitle>Cardiovasc Toxicol</addtitle><addtitle>Cardiovasc Toxicol</addtitle><description>Anthracycline antibiotic is one of the most effective anti-tumor drugs used to manage certain types of breast cancers, lymphomas, and leukemias. However, anthracyclines induce a dose-dependent cardiotoxicity that may progress to heart failure. Thus, using a sensitive predictor of early cardiac dysfunction in patients treated with anthracyclines can help detect subclinical cardiac dysfunction early and help initiate interventions to protect these patients. Among parameters of myocardial measure, cardiac magnetic resonance (CMR)-measured native myocardial T1 mapping is considered a sensitive and accurate quantitative measure of early subclinical cardiac changes, particularly cardiac inflammation and fibrosis. However, to understand the quality and the validity of the current evidence supporting the use of these measures in patients treated with anthracyclines, we aimed to conduct a systematic review of clinical studies of this measure to detect early myocardial changes in cancer patients treated with anthracyclines. The primary outcome was the level of native T1 mapping. We performed fixed-effects meta-analyses and assessed certainty in effect estimates. Of the 1780 publications reviewed (till 2022), 23 were retrieved, and 9 articles met the inclusion criteria. Our study showed that exposure to anthracycline was associated with a significant elevation of native myocardial T1 mapping from baseline (95% CI 0.1121 to 0.5802;
p
= 0.0037) as well as compared to healthy control patients (95% CI 0.2925 to 0.7448;
p
< 0.0001). No significant publication bias was noted on the assessment of the funnel plot and Egger’s test. According to the
Q
test, there was no significant heterogeneity in the included studies (
I
2
= 0.0000% versus healthy controls and
I
2
= 14.0666% versus baseline). Overall, our study suggests that native myocardial T1 mapping is useful for detecting anthracycline-induced cardiotoxicity in patients with cancer.</description><subject>Adult</subject><subject>Aged</subject><subject>Anthracycline</subject><subject>Anthracyclines - adverse effects</subject><subject>Antibiotics, Antineoplastic - adverse effects</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer</subject><subject>Cardiology</subject><subject>Cardiotoxicity</subject><subject>Congestive heart failure</subject><subject>Early Diagnosis</subject><subject>Female</subject><subject>Fibrosis</subject><subject>Heart Diseases - chemically induced</subject><subject>Heart Diseases - diagnosis</subject><subject>Heart Diseases - diagnostic imaging</subject><subject>Heart Diseases - physiopathology</subject><subject>Heterogeneity</subject><subject>Humans</subject><subject>Leukemia</subject><subject>Lymphoma</subject><subject>Magnetic resonance</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Mapping</subject><subject>Meta-analysis</subject><subject>Middle Aged</subject><subject>Neoplasms - drug therapy</subject><subject>Pharmacology/Toxicology</subject><subject>Predictive Value of Tests</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Systematic review</subject><subject>Ventricular Function, Left - drug effects</subject><subject>Young Adult</subject><issn>1530-7905</issn><issn>1559-0259</issn><issn>1559-0259</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><recordid>eNp9UstuEzEUHSEQbQM_wAJZYsNmwI-xZ8wGRaFApQYQZG85njuJqxk72J6U-aD-J05TymPBypbP6175FMUzgl8RjOvXkVBMaIlpVWLZCFGSB8Up4VzmJy4fHu4Ml7XE_KQ4i_EKY0qp4I-LE9bUGAvBT4ubeYwQ4wAuId-hTzrZPaDl5I0OrdU9WhG01LuddRvU-YDOdegn9A4SmGS9O2jmLm2DNpPprYPywrWjgRYtDnqf_A9rbJqQdehL9s4xEV3btM24MxDeII2-TTHBkEGDvsLewjXSrkVLSLrUTvdTtPFJ8ajTfYSnd-esWL0_Xy0-lpefP1ws5pelqahIZc2FaUjTAlQ1Z8S0wkhTw7oGLqquq7o1Y5SBkVAZ3mBt1i3UTDKqjRQdZbPi7dF2N64HaE2eNuhe7YIddJiU11b9jTi7VRu_V4QQTFnOnBUv7xyC_z5CTGqw0UDfawd-jIphjiWrG1Fn6ot_qFd-DHnhW5agXEgqMoseWSb4GAN099MQrA4tUMcWqNwCddsCRbLo-Z973Et-fXsmsCMhZshtIPzO_o_tT-jjwQQ</recordid><startdate>20240601</startdate><enddate>20240601</enddate><creator>Mohamed, Amira A.</creator><creator>Elmancy, Layla Y.</creator><creator>Abulola, Sara M.</creator><creator>Al-Qattan, Sara A.</creator><creator>Mohamed Ibrahim, Mohamed Izham</creator><creator>Maayah, Zaid H.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20240601</creationdate><title>Assessment of Native Myocardial T1 Mapping for Early Detection of Anthracycline-Induced Cardiotoxicity in Patients with Cancer: a Systematic Review and Meta-analysis</title><author>Mohamed, Amira A. ; Elmancy, Layla Y. ; Abulola, Sara M. ; Al-Qattan, Sara A. ; Mohamed Ibrahim, Mohamed Izham ; Maayah, Zaid H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c426t-756c818dee47531cd6c9c7eb7e564ff4fb3323ec9e4c580acbde73932ac96f23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Anthracycline</topic><topic>Anthracyclines - adverse effects</topic><topic>Antibiotics, Antineoplastic - adverse effects</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer</topic><topic>Cardiology</topic><topic>Cardiotoxicity</topic><topic>Congestive heart failure</topic><topic>Early Diagnosis</topic><topic>Female</topic><topic>Fibrosis</topic><topic>Heart Diseases - chemically induced</topic><topic>Heart Diseases - diagnosis</topic><topic>Heart Diseases - diagnostic imaging</topic><topic>Heart Diseases - physiopathology</topic><topic>Heterogeneity</topic><topic>Humans</topic><topic>Leukemia</topic><topic>Lymphoma</topic><topic>Magnetic resonance</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Mapping</topic><topic>Meta-analysis</topic><topic>Middle Aged</topic><topic>Neoplasms - drug therapy</topic><topic>Pharmacology/Toxicology</topic><topic>Predictive Value of Tests</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>Systematic review</topic><topic>Ventricular Function, Left - drug effects</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mohamed, Amira A.</creatorcontrib><creatorcontrib>Elmancy, Layla Y.</creatorcontrib><creatorcontrib>Abulola, Sara M.</creatorcontrib><creatorcontrib>Al-Qattan, Sara A.</creatorcontrib><creatorcontrib>Mohamed Ibrahim, Mohamed Izham</creatorcontrib><creatorcontrib>Maayah, Zaid H.</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cardiovascular toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mohamed, Amira A.</au><au>Elmancy, Layla Y.</au><au>Abulola, Sara M.</au><au>Al-Qattan, Sara A.</au><au>Mohamed Ibrahim, Mohamed Izham</au><au>Maayah, Zaid H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Assessment of Native Myocardial T1 Mapping for Early Detection of Anthracycline-Induced Cardiotoxicity in Patients with Cancer: a Systematic Review and Meta-analysis</atitle><jtitle>Cardiovascular toxicology</jtitle><stitle>Cardiovasc Toxicol</stitle><addtitle>Cardiovasc Toxicol</addtitle><date>2024-06-01</date><risdate>2024</risdate><volume>24</volume><issue>6</issue><spage>563</spage><epage>575</epage><pages>563-575</pages><issn>1530-7905</issn><issn>1559-0259</issn><eissn>1559-0259</eissn><abstract>Anthracycline antibiotic is one of the most effective anti-tumor drugs used to manage certain types of breast cancers, lymphomas, and leukemias. However, anthracyclines induce a dose-dependent cardiotoxicity that may progress to heart failure. Thus, using a sensitive predictor of early cardiac dysfunction in patients treated with anthracyclines can help detect subclinical cardiac dysfunction early and help initiate interventions to protect these patients. Among parameters of myocardial measure, cardiac magnetic resonance (CMR)-measured native myocardial T1 mapping is considered a sensitive and accurate quantitative measure of early subclinical cardiac changes, particularly cardiac inflammation and fibrosis. However, to understand the quality and the validity of the current evidence supporting the use of these measures in patients treated with anthracyclines, we aimed to conduct a systematic review of clinical studies of this measure to detect early myocardial changes in cancer patients treated with anthracyclines. The primary outcome was the level of native T1 mapping. We performed fixed-effects meta-analyses and assessed certainty in effect estimates. Of the 1780 publications reviewed (till 2022), 23 were retrieved, and 9 articles met the inclusion criteria. Our study showed that exposure to anthracycline was associated with a significant elevation of native myocardial T1 mapping from baseline (95% CI 0.1121 to 0.5802;
p
= 0.0037) as well as compared to healthy control patients (95% CI 0.2925 to 0.7448;
p
< 0.0001). No significant publication bias was noted on the assessment of the funnel plot and Egger’s test. According to the
Q
test, there was no significant heterogeneity in the included studies (
I
2
= 0.0000% versus healthy controls and
I
2
= 14.0666% versus baseline). Overall, our study suggests that native myocardial T1 mapping is useful for detecting anthracycline-induced cardiotoxicity in patients with cancer.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>38700665</pmid><doi>10.1007/s12012-024-09866-1</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Cardiovascular toxicology, 2024-06, Vol.24 (6), p.563-575 |
| issn | 1530-7905 1559-0259 1559-0259 |
| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adult Aged Anthracycline Anthracyclines - adverse effects Antibiotics, Antineoplastic - adverse effects Biomedical and Life Sciences Biomedicine Cancer Cardiology Cardiotoxicity Congestive heart failure Early Diagnosis Female Fibrosis Heart Diseases - chemically induced Heart Diseases - diagnosis Heart Diseases - diagnostic imaging Heart Diseases - physiopathology Heterogeneity Humans Leukemia Lymphoma Magnetic resonance Magnetic Resonance Imaging Male Mapping Meta-analysis Middle Aged Neoplasms - drug therapy Pharmacology/Toxicology Predictive Value of Tests Risk Assessment Risk Factors Systematic review Ventricular Function, Left - drug effects Young Adult |
| title | Assessment of Native Myocardial T1 Mapping for Early Detection of Anthracycline-Induced Cardiotoxicity in Patients with Cancer: a Systematic Review and Meta-analysis |
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