Transcription-coupled DNA–protein crosslink repair by CSB and CRL4CSA-mediated degradation

DNA–protein crosslinks (DPCs) arise from enzymatic intermediates, metabolism or chemicals like chemotherapeutics. DPCs are highly cytotoxic as they impede DNA-based processes such as replication, which is counteracted through proteolysis-mediated DPC removal by spartan (SPRTN) or the proteasome. How...

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Veröffentlicht in:	Nature cell biology 2024-05, Vol.26 (5), p.770-783
Hauptverfasser:	van Sluis, Marjolein, Yu, Qing, van der Woude, Melanie, Gonzalo-Hansen, Camila, Dealy, Shannon C., Janssens, Roel C., Somsen, Hedda B., Ramadhin, Anisha R., Dekkers, Dick H. W., Wienecke, Hannah Lena, Demmers, Joris J. P. G., Raams, Anja, Davó-Martínez, Carlota, Llerena Schiffmacher, Diana A., van Toorn, Marvin, Häckes, David, Thijssen, Karen L., Zhou, Di, Lammers, Judith G., Pines, Alex, Vermeulen, Wim, Pothof, Joris, Demmers, Jeroen A. A., van den Berg, Debbie L. C., Lans, Hannes, Marteijn, Jurgen A.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/211 631/337/1427/1430 631/337/572 Biomedical and Life Sciences Cancer Research Cell Biology Cockayne syndrome Crosslinking Cytotoxicity Deoxyribonucleic acid Developmental Biology DNA DNA repair DNA-directed RNA polymerase Genes Intermediates Life Sciences Nucleotide excision repair Nucleotides Proteasomes Proteins Proteolysis Ribonucleic acid RNA RNA polymerase RNA polymerase II Stem Cells Transcription Ubiquitin-protein ligase
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