Migraine-Related Stigma and Its Relationship to Disability, Interictal Burden, and Quality of Life: Results of the OVERCOME (US) Study
This population-based analysis characterizes the relative frequency of migraine-related stigma and its cross-sectional relationship to migraine outcomes. We hypothesized that migraine-related stigma would be inversely associated with favorable migraine outcomes across headache day categories. OVERCO...
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description | This population-based analysis characterizes the relative frequency of migraine-related stigma and its cross-sectional relationship to migraine outcomes. We hypothesized that migraine-related stigma would be inversely associated with favorable migraine outcomes across headache day categories.
OVERCOME (US) is a web-based observational study that annually recruited a demographically representative US sample and then identified people with active migraine using a validated migraine diagnostic questionnaire. It also assessed how frequently respondents experienced migraine-related stigma using a novel 12-item questionnaire (Migraine-Related Stigma, MiRS) that contained 2 factors; feeling that others viewed migraine as being used for Secondary Gain (8 items, α = 0.92) and feeling that others were Minimizing disease Burden (4 items, α = 0.86). We defined 5 groups: (1) MiRS-Both (Secondary Gain and Minimizing Burden often/very often; (2) MiRS-SG (Secondary Gain often/very often); (3) MiRS-MB (Minimizing Burden often/very often); (4) MiRS-Rarely/Sometimes; (5) MiRS-Never. Using MiRS group as the independent variable, we modeled its cross-sectional relationship to disability (Migraine Disability Assessment, MIDAS), interictal burden (Migraine Interictal Burden Scale-4), and migraine-specific quality of life (Migraine Specific Quality of Life v2.1 Role Function-Restrictive) while controlling for sociodemographics, clinical features, and monthly headache day categories.
Among this population-based sample with active migraine (n = 59,001), mean age was 41.3 years and respondents predominantly identified as female (74.9%) and as White (70.1%). Among respondents, 41.1% reported experiencing, on average, ≥4 monthly headache days and 31.7% experienced migraine-related stigma often/very often; the proportion experiencing migraine-related stigma often/very often increased from 25.5% among those with |
doi_str_mv | 10.1212/WNL.0000000000208074 |
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OVERCOME (US) is a web-based observational study that annually recruited a demographically representative US sample and then identified people with active migraine using a validated migraine diagnostic questionnaire. It also assessed how frequently respondents experienced migraine-related stigma using a novel 12-item questionnaire (Migraine-Related Stigma, MiRS) that contained 2 factors; feeling that others viewed migraine as being used for Secondary Gain (8 items, α = 0.92) and feeling that others were Minimizing disease Burden (4 items, α = 0.86). We defined 5 groups: (1) MiRS-Both (Secondary Gain and Minimizing Burden often/very often; (2) MiRS-SG (Secondary Gain often/very often); (3) MiRS-MB (Minimizing Burden often/very often); (4) MiRS-Rarely/Sometimes; (5) MiRS-Never. Using MiRS group as the independent variable, we modeled its cross-sectional relationship to disability (Migraine Disability Assessment, MIDAS), interictal burden (Migraine Interictal Burden Scale-4), and migraine-specific quality of life (Migraine Specific Quality of Life v2.1 Role Function-Restrictive) while controlling for sociodemographics, clinical features, and monthly headache day categories.
Among this population-based sample with active migraine (n = 59,001), mean age was 41.3 years and respondents predominantly identified as female (74.9%) and as White (70.1%). Among respondents, 41.1% reported experiencing, on average, ≥4 monthly headache days and 31.7% experienced migraine-related stigma often/very often; the proportion experiencing migraine-related stigma often/very often increased from 25.5% among those with <4 monthly headache days to 47.5% among those with ≥15 monthly headache days. The risk for increased disability (MIDAS score) was significant for each MiRS group compared with the MiRS-Never group; the risk more than doubled for the MiRS-Both group (rate ratio 2.68, 95% CI 2.56-2.80). For disability, interictal burden, and migraine-specific quality of life, increased migraine-related stigma was associated with increased disease burden across all monthly headache day categories.
OVERCOME (US) found that 31.7% of people with migraine experienced migraine-related stigma often/very often and was associated with more disability, greater interictal burden, and reduced quality of life.</description><identifier>ISSN: 0028-3878</identifier><identifier>EISSN: 1526-632X</identifier><identifier>DOI: 10.1212/WNL.0000000000208074</identifier><identifier>PMID: 38232340</identifier><language>eng</language><publisher>United States: Lippincott Williams & Wilkins</publisher><subject>Adult ; Cost of Illness ; Disability Evaluation ; Female ; Headache ; Humans ; Migraine Disorders - diagnosis ; Migraine Disorders - epidemiology ; Quality of Life ; Surveys and Questionnaires</subject><ispartof>Neurology, 2024-02, Vol.102 (3), p.e208074-e208074</ispartof><rights>Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology. 2024 American Academy of Neurology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c242t-c82b1d0a8c7c056e4903a5b565be508650aca664ea496e6f3d1b6c01c3451e933</cites><orcidid>0000-0002-2725-9739 ; 0000-0002-7401-0514 ; 0000-0002-8938-4949</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38232340$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shapiro, Robert E</creatorcontrib><creatorcontrib>Nicholson, Robert A</creatorcontrib><creatorcontrib>Seng, Elizabeth K</creatorcontrib><creatorcontrib>Buse, Dawn C</creatorcontrib><creatorcontrib>Reed, Michael L</creatorcontrib><creatorcontrib>Zagar, Anthony J</creatorcontrib><creatorcontrib>Ashina, Sait</creatorcontrib><creatorcontrib>Muenzel, E Jolanda</creatorcontrib><creatorcontrib>Hutchinson, Susan</creatorcontrib><creatorcontrib>Pearlman, Eric M</creatorcontrib><creatorcontrib>Lipton, Richard B</creatorcontrib><title>Migraine-Related Stigma and Its Relationship to Disability, Interictal Burden, and Quality of Life: Results of the OVERCOME (US) Study</title><title>Neurology</title><addtitle>Neurology</addtitle><description>This population-based analysis characterizes the relative frequency of migraine-related stigma and its cross-sectional relationship to migraine outcomes. We hypothesized that migraine-related stigma would be inversely associated with favorable migraine outcomes across headache day categories.
OVERCOME (US) is a web-based observational study that annually recruited a demographically representative US sample and then identified people with active migraine using a validated migraine diagnostic questionnaire. It also assessed how frequently respondents experienced migraine-related stigma using a novel 12-item questionnaire (Migraine-Related Stigma, MiRS) that contained 2 factors; feeling that others viewed migraine as being used for Secondary Gain (8 items, α = 0.92) and feeling that others were Minimizing disease Burden (4 items, α = 0.86). We defined 5 groups: (1) MiRS-Both (Secondary Gain and Minimizing Burden often/very often; (2) MiRS-SG (Secondary Gain often/very often); (3) MiRS-MB (Minimizing Burden often/very often); (4) MiRS-Rarely/Sometimes; (5) MiRS-Never. Using MiRS group as the independent variable, we modeled its cross-sectional relationship to disability (Migraine Disability Assessment, MIDAS), interictal burden (Migraine Interictal Burden Scale-4), and migraine-specific quality of life (Migraine Specific Quality of Life v2.1 Role Function-Restrictive) while controlling for sociodemographics, clinical features, and monthly headache day categories.
Among this population-based sample with active migraine (n = 59,001), mean age was 41.3 years and respondents predominantly identified as female (74.9%) and as White (70.1%). Among respondents, 41.1% reported experiencing, on average, ≥4 monthly headache days and 31.7% experienced migraine-related stigma often/very often; the proportion experiencing migraine-related stigma often/very often increased from 25.5% among those with <4 monthly headache days to 47.5% among those with ≥15 monthly headache days. The risk for increased disability (MIDAS score) was significant for each MiRS group compared with the MiRS-Never group; the risk more than doubled for the MiRS-Both group (rate ratio 2.68, 95% CI 2.56-2.80). For disability, interictal burden, and migraine-specific quality of life, increased migraine-related stigma was associated with increased disease burden across all monthly headache day categories.
OVERCOME (US) found that 31.7% of people with migraine experienced migraine-related stigma often/very often and was associated with more disability, greater interictal burden, and reduced quality of life.</description><subject>Adult</subject><subject>Cost of Illness</subject><subject>Disability Evaluation</subject><subject>Female</subject><subject>Headache</subject><subject>Humans</subject><subject>Migraine Disorders - diagnosis</subject><subject>Migraine Disorders - epidemiology</subject><subject>Quality of Life</subject><subject>Surveys and Questionnaires</subject><issn>0028-3878</issn><issn>1526-632X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkdtuEzEURa2Kqg2FP0DIj0XqtL6Nx8MLgpC2kVIieoM3y-M5kxhNZoLtqZQf6HfXvRABfrG099nrHGkj9I6SY8ooO_nxbXZMto8RRQqxg0Y0ZzKTnP18hUZJVhlXhdpHr0P4RUgyi3IP7XPFOOOCjND9hVt44zrILqE1EWp8Fd1iZbDpajyNAT_Jru_C0q1x7PFXF0zlWhc3R3jaRfDORtPiL4OvoTt6in0fzKOP-wbPXAMfEyMMbWIlIS4Bz28nl-P5xQQf3lx9SPuGevMG7TamDfD25T9AN6eT6_F5NpufTcefZ5llgsXMKlbRmhhlC0tyCaIk3ORVLvMKcqJkTow1UgowopQgG17TSlpCLRc5hZLzA_TpmbseqhXUFrroTavX3q2M3-jeOP2v07mlXvR3mlJSFoWkiXD4QvD97wFC1CsXLLSt6aAfgmYllYKooiBpVDyPWt-H4KHZ7qFEP3aoU4f6_w5T7P3fN25Df0rjD2osl5E</recordid><startdate>20240213</startdate><enddate>20240213</enddate><creator>Shapiro, Robert E</creator><creator>Nicholson, Robert A</creator><creator>Seng, Elizabeth K</creator><creator>Buse, Dawn C</creator><creator>Reed, Michael L</creator><creator>Zagar, Anthony J</creator><creator>Ashina, Sait</creator><creator>Muenzel, E Jolanda</creator><creator>Hutchinson, Susan</creator><creator>Pearlman, Eric M</creator><creator>Lipton, Richard B</creator><general>Lippincott Williams & Wilkins</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-2725-9739</orcidid><orcidid>https://orcid.org/0000-0002-7401-0514</orcidid><orcidid>https://orcid.org/0000-0002-8938-4949</orcidid></search><sort><creationdate>20240213</creationdate><title>Migraine-Related Stigma and Its Relationship to Disability, Interictal Burden, and Quality of Life: Results of the OVERCOME (US) Study</title><author>Shapiro, Robert E ; Nicholson, Robert A ; Seng, Elizabeth K ; Buse, Dawn C ; Reed, Michael L ; Zagar, Anthony J ; Ashina, Sait ; Muenzel, E Jolanda ; Hutchinson, Susan ; Pearlman, Eric M ; Lipton, Richard B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c242t-c82b1d0a8c7c056e4903a5b565be508650aca664ea496e6f3d1b6c01c3451e933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Cost of Illness</topic><topic>Disability Evaluation</topic><topic>Female</topic><topic>Headache</topic><topic>Humans</topic><topic>Migraine Disorders - diagnosis</topic><topic>Migraine Disorders - epidemiology</topic><topic>Quality of Life</topic><topic>Surveys and Questionnaires</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shapiro, Robert E</creatorcontrib><creatorcontrib>Nicholson, Robert A</creatorcontrib><creatorcontrib>Seng, Elizabeth K</creatorcontrib><creatorcontrib>Buse, Dawn C</creatorcontrib><creatorcontrib>Reed, Michael L</creatorcontrib><creatorcontrib>Zagar, Anthony J</creatorcontrib><creatorcontrib>Ashina, Sait</creatorcontrib><creatorcontrib>Muenzel, E Jolanda</creatorcontrib><creatorcontrib>Hutchinson, Susan</creatorcontrib><creatorcontrib>Pearlman, Eric M</creatorcontrib><creatorcontrib>Lipton, Richard B</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shapiro, Robert E</au><au>Nicholson, Robert A</au><au>Seng, Elizabeth K</au><au>Buse, Dawn C</au><au>Reed, Michael L</au><au>Zagar, Anthony J</au><au>Ashina, Sait</au><au>Muenzel, E Jolanda</au><au>Hutchinson, Susan</au><au>Pearlman, Eric M</au><au>Lipton, Richard B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Migraine-Related Stigma and Its Relationship to Disability, Interictal Burden, and Quality of Life: Results of the OVERCOME (US) Study</atitle><jtitle>Neurology</jtitle><addtitle>Neurology</addtitle><date>2024-02-13</date><risdate>2024</risdate><volume>102</volume><issue>3</issue><spage>e208074</spage><epage>e208074</epage><pages>e208074-e208074</pages><issn>0028-3878</issn><eissn>1526-632X</eissn><abstract>This population-based analysis characterizes the relative frequency of migraine-related stigma and its cross-sectional relationship to migraine outcomes. We hypothesized that migraine-related stigma would be inversely associated with favorable migraine outcomes across headache day categories.
OVERCOME (US) is a web-based observational study that annually recruited a demographically representative US sample and then identified people with active migraine using a validated migraine diagnostic questionnaire. It also assessed how frequently respondents experienced migraine-related stigma using a novel 12-item questionnaire (Migraine-Related Stigma, MiRS) that contained 2 factors; feeling that others viewed migraine as being used for Secondary Gain (8 items, α = 0.92) and feeling that others were Minimizing disease Burden (4 items, α = 0.86). We defined 5 groups: (1) MiRS-Both (Secondary Gain and Minimizing Burden often/very often; (2) MiRS-SG (Secondary Gain often/very often); (3) MiRS-MB (Minimizing Burden often/very often); (4) MiRS-Rarely/Sometimes; (5) MiRS-Never. Using MiRS group as the independent variable, we modeled its cross-sectional relationship to disability (Migraine Disability Assessment, MIDAS), interictal burden (Migraine Interictal Burden Scale-4), and migraine-specific quality of life (Migraine Specific Quality of Life v2.1 Role Function-Restrictive) while controlling for sociodemographics, clinical features, and monthly headache day categories.
Among this population-based sample with active migraine (n = 59,001), mean age was 41.3 years and respondents predominantly identified as female (74.9%) and as White (70.1%). Among respondents, 41.1% reported experiencing, on average, ≥4 monthly headache days and 31.7% experienced migraine-related stigma often/very often; the proportion experiencing migraine-related stigma often/very often increased from 25.5% among those with <4 monthly headache days to 47.5% among those with ≥15 monthly headache days. The risk for increased disability (MIDAS score) was significant for each MiRS group compared with the MiRS-Never group; the risk more than doubled for the MiRS-Both group (rate ratio 2.68, 95% CI 2.56-2.80). For disability, interictal burden, and migraine-specific quality of life, increased migraine-related stigma was associated with increased disease burden across all monthly headache day categories.
OVERCOME (US) found that 31.7% of people with migraine experienced migraine-related stigma often/very often and was associated with more disability, greater interictal burden, and reduced quality of life.</abstract><cop>United States</cop><pub>Lippincott Williams & Wilkins</pub><pmid>38232340</pmid><doi>10.1212/WNL.0000000000208074</doi><orcidid>https://orcid.org/0000-0002-2725-9739</orcidid><orcidid>https://orcid.org/0000-0002-7401-0514</orcidid><orcidid>https://orcid.org/0000-0002-8938-4949</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Adult Cost of Illness Disability Evaluation Female Headache Humans Migraine Disorders - diagnosis Migraine Disorders - epidemiology Quality of Life Surveys and Questionnaires |
title | Migraine-Related Stigma and Its Relationship to Disability, Interictal Burden, and Quality of Life: Results of the OVERCOME (US) Study |
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