Extramedullary haematopoiesis in a patient with myelofibrosis
Megakaryocytes are large multilobulated precursor cells which usually reside within the bone marrow and give rise to platelets. There have been rare occurrences where they have been found in peripheral blood and extramedullary tissues in conditions where the underlying mechanisms of the bone marrow...
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| Veröffentlicht in: | Clinical medicine (London, England) England), 2024-05, Vol.24 (3), p.100203-3, Article 100203 |
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| creator | Pasangha, Elaina Wall, Johanna Arasaretnam, Anita |
| description | Megakaryocytes are large multilobulated precursor cells which usually reside within the bone marrow and give rise to platelets. There have been rare occurrences where they have been found in peripheral blood and extramedullary tissues in conditions where the underlying mechanisms of the bone marrow have been affected. This case report discusses an unusual presentation of a man with myelofibrosis who was found to have megakaryocytes in his ascitic fluid. We have highlighted the images showing utility of combination of traditional staining methods and immunohistochemistry in combating this diagnostic dilemma. |
| doi_str_mv | 10.1016/j.clinme.2024.100203 |
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There have been rare occurrences where they have been found in peripheral blood and extramedullary tissues in conditions where the underlying mechanisms of the bone marrow have been affected. This case report discusses an unusual presentation of a man with myelofibrosis who was found to have megakaryocytes in his ascitic fluid. We have highlighted the images showing utility of combination of traditional staining methods and immunohistochemistry in combating this diagnostic dilemma.</description><identifier>ISSN: 1470-2118</identifier><identifier>EISSN: 1473-4893</identifier><identifier>DOI: 10.1016/j.clinme.2024.100203</identifier><identifier>PMID: 38643827</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Antigens ; Bone marrow ; Case Report ; Hematopoiesis, Extramedullary ; Hospitals ; Humans ; Immunohistochemistry ; Male ; Megakaryocytes - pathology ; Melanoma ; Middle Aged ; Primary Myelofibrosis - complications ; Primary Myelofibrosis - diagnosis ; Primary Myelofibrosis - pathology ; Sepsis</subject><ispartof>Clinical medicine (London, England), 2024-05, Vol.24 (3), p.100203-3, Article 100203</ispartof><rights>2024 The Author(s)</rights><rights>Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.</rights><rights>Copyright Royal College of Physicians May 2024</rights><rights>2024 The Author(s) 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c492t-55b375d091cbde87186b01df02ad2e54ca137b2db084b935022a12f07c4ea9013</citedby><cites>FETCH-LOGICAL-c492t-55b375d091cbde87186b01df02ad2e54ca137b2db084b935022a12f07c4ea9013</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11096983/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11096983/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38643827$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pasangha, Elaina</creatorcontrib><creatorcontrib>Wall, Johanna</creatorcontrib><creatorcontrib>Arasaretnam, Anita</creatorcontrib><title>Extramedullary haematopoiesis in a patient with myelofibrosis</title><title>Clinical medicine (London, England)</title><addtitle>Clin Med (Lond)</addtitle><description>Megakaryocytes are large multilobulated precursor cells which usually reside within the bone marrow and give rise to platelets. 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We have highlighted the images showing utility of combination of traditional staining methods and immunohistochemistry in combating this diagnostic dilemma.</description><subject>Antigens</subject><subject>Bone marrow</subject><subject>Case Report</subject><subject>Hematopoiesis, Extramedullary</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Male</subject><subject>Megakaryocytes - pathology</subject><subject>Melanoma</subject><subject>Middle Aged</subject><subject>Primary Myelofibrosis - complications</subject><subject>Primary Myelofibrosis - diagnosis</subject><subject>Primary Myelofibrosis - pathology</subject><subject>Sepsis</subject><issn>1470-2118</issn><issn>1473-4893</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kEtPwzAQhC0EoqXwDxCKxDll13ZeB0CoKg-pEhc4W47jUFdJXJy00H-PS0oFF062vLMz44-Qc4QxAsZXi7GqTFPrMQXK_RNQYAdkiDxhIU8zdvh9h5AipgNy0rYLAIx4Fh-TAUtjzlKaDMn19LNzstbFqqqk2wRzqWvZ2aU1ujVtYJpABkvZGd10wYfp5kG90ZUtTe6sn5-So1JWrT7bnSPyej99mTyGs-eHp8ndLFQ8o10YRTlLogIyVHmh0wTTOAcsSqCyoDriSiJLclrkkPI8YxFQKpGWkCiuZQbIRuS2912uct9V-TZOVmLpTO1LCyuN-DtpzFy82bVAhCzOUuYdLncOzr6vdNuJhV25xpcWDDHCiPlYr-K9SvnvtU6X-wgEsaUuFqKnLrbURU_dr138rrdf-sHsBTe9QHtIa6OdaJVHqnRhnFadKKz5P-ELlBqVrg</recordid><startdate>20240501</startdate><enddate>20240501</enddate><creator>Pasangha, Elaina</creator><creator>Wall, Johanna</creator><creator>Arasaretnam, Anita</creator><general>Elsevier Ltd</general><general>Royal College of Physicians</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>4T-</scope><scope>4U-</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>EHMNL</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope></search><sort><creationdate>20240501</creationdate><title>Extramedullary haematopoiesis in a patient with myelofibrosis</title><author>Pasangha, Elaina ; 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There have been rare occurrences where they have been found in peripheral blood and extramedullary tissues in conditions where the underlying mechanisms of the bone marrow have been affected. This case report discusses an unusual presentation of a man with myelofibrosis who was found to have megakaryocytes in his ascitic fluid. We have highlighted the images showing utility of combination of traditional staining methods and immunohistochemistry in combating this diagnostic dilemma.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>38643827</pmid><doi>10.1016/j.clinme.2024.100203</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1470-2118 |
| ispartof | Clinical medicine (London, England), 2024-05, Vol.24 (3), p.100203-3, Article 100203 |
| issn | 1470-2118 1473-4893 |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Antigens Bone marrow Case Report Hematopoiesis, Extramedullary Hospitals Humans Immunohistochemistry Male Megakaryocytes - pathology Melanoma Middle Aged Primary Myelofibrosis - complications Primary Myelofibrosis - diagnosis Primary Myelofibrosis - pathology Sepsis |
| title | Extramedullary haematopoiesis in a patient with myelofibrosis |
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