Effect of Daily Vitamin D Supplementation on Risk of Upper Respiratory Infection in Older Adults: A Randomized Controlled Trial
Abstract Background Among individuals with vitamin D deficiency, daily vitamin D supplementation appears to lower risk of acute respiratory infection. However, recent trials, in different populations and using different regimens, have yielded null results. We investigated the effect of daily vitamin...
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| Veröffentlicht in: | Clinical infectious diseases 2024-05, Vol.78 (5), p.1162-1169 |
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| creator | Camargo, Carlos A Schaumberg, Debra A Friedenberg, Georgina Dushkes, Rimma Glynn, Robert J Gold, Diane R Mora, Samia Lee, I Min Buring, Julie E Manson, JoAnn E |
| description | Abstract
Background
Among individuals with vitamin D deficiency, daily vitamin D supplementation appears to lower risk of acute respiratory infection. However, recent trials, in different populations and using different regimens, have yielded null results. We investigated the effect of daily vitamin D supplementation (vs placebo) on risk of upper respiratory infection (URI) in older adults.
Methods
The VITamin D and OmegA-3 TriaL (VITAL) is a randomized, double-blind, placebo-controlled trial of supplemental vitamin D and/or omega-3 fatty acids in generally healthy men (age ≥50 years) and women (age ≥55 years). This prespecified analysis focuses on vitamin D3 (2000 IU/day) versus placebo in the 15 804 (61%) participants with baseline serum total 25-hydroxyvitamin D level. The primary outcome was self-report of a recent URI at 1-year follow-up.
Results
Participants had a mean age of 68 years and 51% were women; 76% were non-Hispanic White, 16% Black, and 8% other race/ethnicity. The mean 25-hydroxyvitamin D level at baseline was 31 (standard deviation, 10) ng/mL, with |
| doi_str_mv | 10.1093/cid/ciad770 |
| format | Article |
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Background
Among individuals with vitamin D deficiency, daily vitamin D supplementation appears to lower risk of acute respiratory infection. However, recent trials, in different populations and using different regimens, have yielded null results. We investigated the effect of daily vitamin D supplementation (vs placebo) on risk of upper respiratory infection (URI) in older adults.
Methods
The VITamin D and OmegA-3 TriaL (VITAL) is a randomized, double-blind, placebo-controlled trial of supplemental vitamin D and/or omega-3 fatty acids in generally healthy men (age ≥50 years) and women (age ≥55 years). This prespecified analysis focuses on vitamin D3 (2000 IU/day) versus placebo in the 15 804 (61%) participants with baseline serum total 25-hydroxyvitamin D level. The primary outcome was self-report of a recent URI at 1-year follow-up.
Results
Participants had a mean age of 68 years and 51% were women; 76% were non-Hispanic White, 16% Black, and 8% other race/ethnicity. The mean 25-hydroxyvitamin D level at baseline was 31 (standard deviation, 10) ng/mL, with <12 ng/mL in 2.4%. The overall effect of vitamin D supplementation on recent URI was nonsignificant (odds ratio [OR], 0.96 [95% confidence interval {CI}, .86–1.06]). In the prespecified subgroup of primary interest (<12 ng/mL and denied taking concurrent vitamin D), which had only 255 participants, vitamin D supplementation was nonsignificant (OR, 0.60 [95% CI, .28–1.30]). Statistical power to assess effect modification in other subgroups was limited.
Conclusions
In older adults not selected for vitamin D deficiency, supplemental vitamin D did not lower URI risk overall. Whether effects differ in subgroups requires further study.
Clinical Trials Registration. NCT01169259.
Graphical Abstract
Graphical Abstract
This graphical abstract is also available at Tidbit: https://tidbitapp.io/tidbits/effect-of-daily-vitamin-d-supplementation-on-risk-of-upper-respiratory-infection-in-older-adults-a-randomized-controlled-trial
In a randomized trial of >15 000 older adults not selected for vitamin D deficiency, vitamin D supplementation did not prevent upper respiratory infections overall. Whether effects differ in subgroups requires further study.</description><identifier>ISSN: 1058-4838</identifier><identifier>ISSN: 1537-6591</identifier><identifier>EISSN: 1537-6591</identifier><identifier>DOI: 10.1093/cid/ciad770</identifier><identifier>PMID: 38113446</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Aged ; Dietary Supplements ; Double-Blind Method ; Editor's Choice ; Fatty Acids, Omega-3 - administration & dosage ; Fatty Acids, Omega-3 - therapeutic use ; Female ; Humans ; Major ; Male ; Middle Aged ; Respiratory Tract Infections - epidemiology ; Respiratory Tract Infections - prevention & control ; Vitamin D - administration & dosage ; Vitamin D - analogs & derivatives ; Vitamin D - blood ; Vitamin D Deficiency - complications ; Vitamin D Deficiency - drug therapy</subject><ispartof>Clinical infectious diseases, 2024-05, Vol.78 (5), p.1162-1169</ispartof><rights>The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com 2023</rights><rights>The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c413t-975ee01fbe1f8fa06b17231be25edc323d7402385b0faf63e8aa6e7972726f723</citedby><cites>FETCH-LOGICAL-c413t-975ee01fbe1f8fa06b17231be25edc323d7402385b0faf63e8aa6e7972726f723</cites><orcidid>0000-0002-5071-7654 ; 0000-0002-9426-7595 ; 0000-0001-6283-0980</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,1583,27915,27916</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38113446$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Camargo, Carlos A</creatorcontrib><creatorcontrib>Schaumberg, Debra A</creatorcontrib><creatorcontrib>Friedenberg, Georgina</creatorcontrib><creatorcontrib>Dushkes, Rimma</creatorcontrib><creatorcontrib>Glynn, Robert J</creatorcontrib><creatorcontrib>Gold, Diane R</creatorcontrib><creatorcontrib>Mora, Samia</creatorcontrib><creatorcontrib>Lee, I Min</creatorcontrib><creatorcontrib>Buring, Julie E</creatorcontrib><creatorcontrib>Manson, JoAnn E</creatorcontrib><title>Effect of Daily Vitamin D Supplementation on Risk of Upper Respiratory Infection in Older Adults: A Randomized Controlled Trial</title><title>Clinical infectious diseases</title><addtitle>Clin Infect Dis</addtitle><description>Abstract
Background
Among individuals with vitamin D deficiency, daily vitamin D supplementation appears to lower risk of acute respiratory infection. However, recent trials, in different populations and using different regimens, have yielded null results. We investigated the effect of daily vitamin D supplementation (vs placebo) on risk of upper respiratory infection (URI) in older adults.
Methods
The VITamin D and OmegA-3 TriaL (VITAL) is a randomized, double-blind, placebo-controlled trial of supplemental vitamin D and/or omega-3 fatty acids in generally healthy men (age ≥50 years) and women (age ≥55 years). This prespecified analysis focuses on vitamin D3 (2000 IU/day) versus placebo in the 15 804 (61%) participants with baseline serum total 25-hydroxyvitamin D level. The primary outcome was self-report of a recent URI at 1-year follow-up.
Results
Participants had a mean age of 68 years and 51% were women; 76% were non-Hispanic White, 16% Black, and 8% other race/ethnicity. The mean 25-hydroxyvitamin D level at baseline was 31 (standard deviation, 10) ng/mL, with <12 ng/mL in 2.4%. The overall effect of vitamin D supplementation on recent URI was nonsignificant (odds ratio [OR], 0.96 [95% confidence interval {CI}, .86–1.06]). In the prespecified subgroup of primary interest (<12 ng/mL and denied taking concurrent vitamin D), which had only 255 participants, vitamin D supplementation was nonsignificant (OR, 0.60 [95% CI, .28–1.30]). Statistical power to assess effect modification in other subgroups was limited.
Conclusions
In older adults not selected for vitamin D deficiency, supplemental vitamin D did not lower URI risk overall. Whether effects differ in subgroups requires further study.
Clinical Trials Registration. NCT01169259.
Graphical Abstract
Graphical Abstract
This graphical abstract is also available at Tidbit: https://tidbitapp.io/tidbits/effect-of-daily-vitamin-d-supplementation-on-risk-of-upper-respiratory-infection-in-older-adults-a-randomized-controlled-trial
In a randomized trial of >15 000 older adults not selected for vitamin D deficiency, vitamin D supplementation did not prevent upper respiratory infections overall. Whether effects differ in subgroups requires further study.</description><subject>Aged</subject><subject>Dietary Supplements</subject><subject>Double-Blind Method</subject><subject>Editor's Choice</subject><subject>Fatty Acids, Omega-3 - administration & dosage</subject><subject>Fatty Acids, Omega-3 - therapeutic use</subject><subject>Female</subject><subject>Humans</subject><subject>Major</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Respiratory Tract Infections - epidemiology</subject><subject>Respiratory Tract Infections - prevention & control</subject><subject>Vitamin D - administration & dosage</subject><subject>Vitamin D - analogs & derivatives</subject><subject>Vitamin D - blood</subject><subject>Vitamin D Deficiency - complications</subject><subject>Vitamin D Deficiency - drug therapy</subject><issn>1058-4838</issn><issn>1537-6591</issn><issn>1537-6591</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc9rFDEUgIMo9oeevJecRCijyWQmyXiRZVu1UCisrdeQmXmxaTOTMckI20v_dTPsWvQiJOTB-973kjyE3lDynpKGfehsn7fuhSDP0CGtmSh43dDnOSa1LCrJ5AE6ivGOEEolqV-iAyYpZVXFD9HjuTHQJewNPtPWbfF3m_RgR3yGv83T5GCAMelk_Yjz2th4v6A30wQBbyBONujkwxZfjItmwXLtletzetXPLsWPeIU3euz9YB-gx2s_puCdy-F1sNq9Qi-MdhFe789jdPP5_Hr9tbi8-nKxXl0WXUVZKhpRAxBqWqBGGk14S0XJaAtlDX3HStaLipRM1i0x2nAGUmsOohGlKLnJ6DH6tPNOczvkkvyqoJ2agh102Cqvrfo3M9pb9cP_UnT5Y855NrzbG4L_OUNMarCxA-f0CH6OqmxIReuKEZnR0x3aBR9jAPPUhxK1-FSemdrPLNMnf1_tif0zpAy83QF-nv5r-g1nIaJI</recordid><startdate>20240515</startdate><enddate>20240515</enddate><creator>Camargo, Carlos A</creator><creator>Schaumberg, Debra A</creator><creator>Friedenberg, Georgina</creator><creator>Dushkes, Rimma</creator><creator>Glynn, Robert J</creator><creator>Gold, Diane R</creator><creator>Mora, Samia</creator><creator>Lee, I Min</creator><creator>Buring, Julie E</creator><creator>Manson, JoAnn E</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-5071-7654</orcidid><orcidid>https://orcid.org/0000-0002-9426-7595</orcidid><orcidid>https://orcid.org/0000-0001-6283-0980</orcidid></search><sort><creationdate>20240515</creationdate><title>Effect of Daily Vitamin D Supplementation on Risk of Upper Respiratory Infection in Older Adults: A Randomized Controlled Trial</title><author>Camargo, Carlos A ; Schaumberg, Debra A ; Friedenberg, Georgina ; Dushkes, Rimma ; Glynn, Robert J ; Gold, Diane R ; Mora, Samia ; Lee, I Min ; Buring, Julie E ; Manson, JoAnn E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c413t-975ee01fbe1f8fa06b17231be25edc323d7402385b0faf63e8aa6e7972726f723</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Aged</topic><topic>Dietary Supplements</topic><topic>Double-Blind Method</topic><topic>Editor's Choice</topic><topic>Fatty Acids, Omega-3 - administration & dosage</topic><topic>Fatty Acids, Omega-3 - therapeutic use</topic><topic>Female</topic><topic>Humans</topic><topic>Major</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Respiratory Tract Infections - epidemiology</topic><topic>Respiratory Tract Infections - prevention & control</topic><topic>Vitamin D - administration & dosage</topic><topic>Vitamin D - analogs & derivatives</topic><topic>Vitamin D - blood</topic><topic>Vitamin D Deficiency - complications</topic><topic>Vitamin D Deficiency - drug therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Camargo, Carlos A</creatorcontrib><creatorcontrib>Schaumberg, Debra A</creatorcontrib><creatorcontrib>Friedenberg, Georgina</creatorcontrib><creatorcontrib>Dushkes, Rimma</creatorcontrib><creatorcontrib>Glynn, Robert J</creatorcontrib><creatorcontrib>Gold, Diane R</creatorcontrib><creatorcontrib>Mora, Samia</creatorcontrib><creatorcontrib>Lee, I Min</creatorcontrib><creatorcontrib>Buring, Julie E</creatorcontrib><creatorcontrib>Manson, JoAnn E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Clinical infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Camargo, Carlos A</au><au>Schaumberg, Debra A</au><au>Friedenberg, Georgina</au><au>Dushkes, Rimma</au><au>Glynn, Robert J</au><au>Gold, Diane R</au><au>Mora, Samia</au><au>Lee, I Min</au><au>Buring, Julie E</au><au>Manson, JoAnn E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Daily Vitamin D Supplementation on Risk of Upper Respiratory Infection in Older Adults: A Randomized Controlled Trial</atitle><jtitle>Clinical infectious diseases</jtitle><addtitle>Clin Infect Dis</addtitle><date>2024-05-15</date><risdate>2024</risdate><volume>78</volume><issue>5</issue><spage>1162</spage><epage>1169</epage><pages>1162-1169</pages><issn>1058-4838</issn><issn>1537-6591</issn><eissn>1537-6591</eissn><abstract>Abstract
Background
Among individuals with vitamin D deficiency, daily vitamin D supplementation appears to lower risk of acute respiratory infection. However, recent trials, in different populations and using different regimens, have yielded null results. We investigated the effect of daily vitamin D supplementation (vs placebo) on risk of upper respiratory infection (URI) in older adults.
Methods
The VITamin D and OmegA-3 TriaL (VITAL) is a randomized, double-blind, placebo-controlled trial of supplemental vitamin D and/or omega-3 fatty acids in generally healthy men (age ≥50 years) and women (age ≥55 years). This prespecified analysis focuses on vitamin D3 (2000 IU/day) versus placebo in the 15 804 (61%) participants with baseline serum total 25-hydroxyvitamin D level. The primary outcome was self-report of a recent URI at 1-year follow-up.
Results
Participants had a mean age of 68 years and 51% were women; 76% were non-Hispanic White, 16% Black, and 8% other race/ethnicity. The mean 25-hydroxyvitamin D level at baseline was 31 (standard deviation, 10) ng/mL, with <12 ng/mL in 2.4%. The overall effect of vitamin D supplementation on recent URI was nonsignificant (odds ratio [OR], 0.96 [95% confidence interval {CI}, .86–1.06]). In the prespecified subgroup of primary interest (<12 ng/mL and denied taking concurrent vitamin D), which had only 255 participants, vitamin D supplementation was nonsignificant (OR, 0.60 [95% CI, .28–1.30]). Statistical power to assess effect modification in other subgroups was limited.
Conclusions
In older adults not selected for vitamin D deficiency, supplemental vitamin D did not lower URI risk overall. Whether effects differ in subgroups requires further study.
Clinical Trials Registration. NCT01169259.
Graphical Abstract
Graphical Abstract
This graphical abstract is also available at Tidbit: https://tidbitapp.io/tidbits/effect-of-daily-vitamin-d-supplementation-on-risk-of-upper-respiratory-infection-in-older-adults-a-randomized-controlled-trial
In a randomized trial of >15 000 older adults not selected for vitamin D deficiency, vitamin D supplementation did not prevent upper respiratory infections overall. Whether effects differ in subgroups requires further study.</abstract><cop>US</cop><pub>Oxford University Press</pub><pmid>38113446</pmid><doi>10.1093/cid/ciad770</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-5071-7654</orcidid><orcidid>https://orcid.org/0000-0002-9426-7595</orcidid><orcidid>https://orcid.org/0000-0001-6283-0980</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1058-4838 |
| ispartof | Clinical infectious diseases, 2024-05, Vol.78 (5), p.1162-1169 |
| issn | 1058-4838 1537-6591 1537-6591 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11093666 |
| source | Oxford University Press Journals; MEDLINE |
| subjects | Aged Dietary Supplements Double-Blind Method Editor's Choice Fatty Acids, Omega-3 - administration & dosage Fatty Acids, Omega-3 - therapeutic use Female Humans Major Male Middle Aged Respiratory Tract Infections - epidemiology Respiratory Tract Infections - prevention & control Vitamin D - administration & dosage Vitamin D - analogs & derivatives Vitamin D - blood Vitamin D Deficiency - complications Vitamin D Deficiency - drug therapy |
| title | Effect of Daily Vitamin D Supplementation on Risk of Upper Respiratory Infection in Older Adults: A Randomized Controlled Trial |
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