Mediator kinase inhibition reverses castration resistance of advanced prostate cancer

Mediator kinases CDK19 and CDK8, pleiotropic regulators of transcriptional reprogramming, are differentially regulated by androgen signaling but both kinases are upregulated in castration-resistant prostate cancer (CRPC). Genetic or pharmacological inhibition of CDK8 and CDK19 reverses the castratio...

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Veröffentlicht in:	The Journal of clinical investigation 2024-05, Vol.134 (10)
Hauptverfasser:	Li, Jing, Hilimire, Thomas A, Yueying, Liu, Wang, Lili, Liang, Jiaxin, Győrffy, Balázs, Sikirzhytski, Vitali, Ji, Hao, Zhang, Li, Cheng, Chen, Ding, Xiaokai, Kerr, Kendall R, Dowling, Charles E, Chumanevich, Alexander A, Mack, Zachary T, Schools, Gary P, Lim, Chang-Uk, Ellis, Leigh, Zi, Xiaolin, Porter, Donald C, Broude, Eugenia V, McInnes, Campbell, Wilding, George, Lilly, Michael B, Roninson, Igor B, Chen, Mengqian
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Antimitotic agents Antineoplastic agents Development and progression Diagnosis Drug therapy Gene expression Metastasis Patient outcomes Prostate cancer
Online-Zugang:	Volltext
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