Multicenter assessment and longitudinal study of the prevalence of antibodies and related adaptive immune responses to AAV in adult males with hemophilia

Adeno-associated virus (AAV) based gene therapy has demonstrated effective disease control in hemophilia. However, pre-existing immunity from wild-type AAV exposure impacts gene therapy eligibility. The aim of this multicenter epidemiologic study was to determine the prevalence and persistence of pr...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Gene therapy 2024-05, Vol.31 (5-6), p.273-284
Hauptverfasser:	Pabinger, Ingrid, Ayash-Rashkovsky, Mila, Escobar, Miguel, Konkle, Barbara A., Mingot-Castellano, María Eva, Mullins, Eric S., Negrier, Claude, Pan, Luying, Rajavel, Kavitha, Yan, Brian, Chapin, John
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/44 38 38/1 631/1647 692/699/1541 Adaptive Immunity Adenoviruses Adult Antibodies Antibodies, Neutralizing - blood Antibodies, Neutralizing - immunology Antibodies, Viral - blood Biomedical and Life Sciences Biomedicine Capsids Cell Biology Cell-mediated immunity Dependovirus - genetics Dependovirus - immunology Disease control Enzyme-linked immunosorbent assay Epidemiology Gene Expression Gene Therapy Genetic Therapy - methods Genetic Vectors - administration & dosage Genetic Vectors - genetics Genetic Vectors - immunology Hemophilia Hemophilia A - immunology Hemophilia A - therapy Human Genetics Humans Immune response Immune response (humoral) Immunoassay Longitudinal Studies Male Middle Aged Nanotechnology Prevalence Serology Serotypes Young Adult
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!