Identification of optimal therapeutic window for steroid use in severe alcohol-associated hepatitis: A worldwide study

Corticosteroids are the only effective therapy for severe alcohol-associated hepatitis (AH), defined by a model for end-stage liver disease (MELD) score >20. However, there are patients who may be too sick to benefit from therapy. Herein, we aimed to identify the range of MELD scores within which...

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Veröffentlicht in:	Journal of hepatology 2021-11, Vol.75 (5), p.1026-1033
Hauptverfasser:	Arab, Juan Pablo, Díaz, Luis Antonio, Baeza, Natalia, Idalsoaga, Francisco, Fuentes-López, Eduardo, Arnold, Jorge, Ramírez, Carolina A., Morales-Arraez, Dalia, Ventura-Cots, Meritxell, Alvarado-Tapias, Edilmar, Zhang, Wei, Clark, Virginia, Simonetto, Douglas, Ahn, Joseph C., Buryska, Seth, Mehta, Tej I., Stefanescu, Horia, Horhat, Adelina, Bumbu, Andreea, Dunn, Winston, Attar, Bashar, Agrawal, Rohit, Haque, Zohaib Syed, Majeed, Muhammad, Cabezas, Joaquín, García-Carrera, Inés, Parker, Richard, Cuyàs, Berta, Poca, Maria, Soriano, German, Sarin, Shiv K., Maiwall, Rakhi, Jalal, Prasun K., Abdulsada, Saba, Higuera-de la Tijera, María Fátima, Kulkarni, Anand V., Rao, P Nagaraja, Guerra Salazar, Patricia, Skladaný, Lubomir, Bystrianska, Natália, Prado, Veronica, Clemente-Sanchez, Ana, Rincón, Diego, Haider, Tehseen, Chacko, Kristina R., Cairo, Fernando, de Sousa Coelho, Marcela, Romero, Gustavo A., Pollarsky, Florencia D., Restrepo, Juan Carlos, Castro-Sanchez, Susana, Toro, Luis G., Yaquich, Pamela, Mendizabal, Manuel, Garrido, Maria Laura, Narvaez, Adrián, Bessone, Fernando, Marcelo, Julio Santiago, Piombino, Diego, Dirchwolf, Melisa, Arancibia, Juan Pablo, Altamirano, José, Kim, Won, Araujo, Roberta C., Duarte-Rojo, Andrés, Vargas, Victor, Rautou, Pierre-Emmanuel, Issoufaly, Tazime, Zamarripa, Felipe, Torre, Aldo, Lucey, Michael R., Mathurin, Philippe, Louvet, Alexandre, García-Tsao, Guadalupe, González, José Alberto, Verna, Elizabeth, Brown, Robert S., Roblero, Juan Pablo, Abraldes, Juan G., Arrese, Marco, Shah, Vijay H., Kamath, Patrick S., Singal, Ashwani K., Bataller, Ramon
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Alcohol Alcohol Drinking - adverse effects Alcohol Drinking - drug therapy Alcohol Drinking - physiopathology alcohol-associated liver disease alcoholic hepatitis alcoholic liver disease Cirrhosis Cohort Studies Corticosteroids Female Hepatitis Hepatitis - drug therapy Hepatitis - etiology Humans Inflammation Life Sciences Liver cirrhosis Liver diseases Maddrey discriminant function Male MELD Methylprednisolone Middle Aged Mortality Patients Prednisolone Prednisone Retrospective Studies Severity of Illness Index Steroid hormones Steroids Steroids - administration & dosage Steroids - therapeutic use Survival Survival analysis Time Factors
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