Longitudinal characteristics of physical frailty and its components in men and women post hip fracture
Frailty is an important geriatric syndrome predicting adverse health outcomes in older adults. However, the longitudinal characteristics of frailty components in post-hip fracture patients are less understood. Adopting the Fried frailty definition, we examined the longitudinal trends and sex traject...
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| Veröffentlicht in: | Journal of the American Geriatrics Society (JAGS) 2024-01, Vol.72 (1), p.170-180 |
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| creator | Huang, Yi Orwig, Denise Hayssen, Hilary Lu, Wenxin Gruber-Baldini, Ann L Chiles Shaffer, Nancy Magaziner, Jay Guralnik, Jack M |
| description | Frailty is an important geriatric syndrome predicting adverse health outcomes in older adults. However, the longitudinal characteristics of frailty components in post-hip fracture patients are less understood. Adopting the Fried frailty definition, we examined the longitudinal trends and sex trajectory differences in frailty and its components over 1 year post-fracture.
Three hundred and twenty-seven hip fracture patients (162 men and 165 women with mean age 80.1 and 81.5) from Baltimore Hip Studies 7th cohort with measurements at 22 days after admission, and months 2, 6, and 12 post-fracture were analyzed. Frailty components included: grip strength, gait speed, weight, total energy expenditure, and exhaustion. Longitudinal analysis used mixed effect models.
At baseline, men were sicker with worse cognitive status, and had higher weight and grip strength, but lower total energy expenditure than women (p |
| doi_str_mv | 10.1111/jgs.18595 |
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Three hundred and twenty-seven hip fracture patients (162 men and 165 women with mean age 80.1 and 81.5) from Baltimore Hip Studies 7th cohort with measurements at 22 days after admission, and months 2, 6, and 12 post-fracture were analyzed. Frailty components included: grip strength, gait speed, weight, total energy expenditure, and exhaustion. Longitudinal analysis used mixed effect models.
At baseline, men were sicker with worse cognitive status, and had higher weight and grip strength, but lower total energy expenditure than women (p < 0.001). The prevalence of frailty was 31.5%, 30.2%, and 28.2% at months 2, 6, and 12 respectively, showing no longitudinal trends or sex differences. However, its components showed substantial recovery trends over the post-fracture year after confounding adjustments, including increasing gait speed, reducing risk of exhaustion, and stabilized weight loss and energy expenditure over time. Particularly, while men's grip strength tended to remain stable over first year post surgery within patients, women's grip strength reduced significantly over time within patients. On average over time within patients, women were more active with higher energy expenditures but lower grip strength and weight than men.
Significant recovery trends and sex differences were observed in frailty components during first year post-fracture. Overall frailty status did not show those trends over months 2-12 since a summary measure might obscure changes in components. Therefore, frailty components provided important multi-dimensional information on the complex recovery process of patients, indicating targets for intervention beyond the global binary measure of frailty.</description><identifier>ISSN: 0002-8614</identifier><identifier>ISSN: 1532-5415</identifier><identifier>EISSN: 1532-5415</identifier><identifier>DOI: 10.1111/jgs.18595</identifier><identifier>PMID: 37725439</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Aged ; Aged, 80 and over ; Body weight loss ; Cognitive ability ; Energy expenditure ; Female ; Fractures ; Frail Elderly - psychology ; Frailty ; Frailty - epidemiology ; Gait ; Gender differences ; Geriatric Assessment - methods ; Hip ; Hip Fractures - epidemiology ; Hip joint ; Hospitalization ; Humans ; Male ; Older people ; Prospective Studies ; Sex differences ; Trends ; Women</subject><ispartof>Journal of the American Geriatrics Society (JAGS), 2024-01, Vol.72 (1), p.170-180</ispartof><rights>2023 The American Geriatrics Society.</rights><rights>2024 American Geriatrics Society and Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c369t-2cd65dc19455be045c7b4fc322e1ff37a0001c2e89eef57b20cc8839e1ce48d93</citedby><cites>FETCH-LOGICAL-c369t-2cd65dc19455be045c7b4fc322e1ff37a0001c2e89eef57b20cc8839e1ce48d93</cites><orcidid>0000-0002-6321-3922</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37725439$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Huang, Yi</creatorcontrib><creatorcontrib>Orwig, Denise</creatorcontrib><creatorcontrib>Hayssen, Hilary</creatorcontrib><creatorcontrib>Lu, Wenxin</creatorcontrib><creatorcontrib>Gruber-Baldini, Ann L</creatorcontrib><creatorcontrib>Chiles Shaffer, Nancy</creatorcontrib><creatorcontrib>Magaziner, Jay</creatorcontrib><creatorcontrib>Guralnik, Jack M</creatorcontrib><title>Longitudinal characteristics of physical frailty and its components in men and women post hip fracture</title><title>Journal of the American Geriatrics Society (JAGS)</title><addtitle>J Am Geriatr Soc</addtitle><description>Frailty is an important geriatric syndrome predicting adverse health outcomes in older adults. However, the longitudinal characteristics of frailty components in post-hip fracture patients are less understood. Adopting the Fried frailty definition, we examined the longitudinal trends and sex trajectory differences in frailty and its components over 1 year post-fracture.
Three hundred and twenty-seven hip fracture patients (162 men and 165 women with mean age 80.1 and 81.5) from Baltimore Hip Studies 7th cohort with measurements at 22 days after admission, and months 2, 6, and 12 post-fracture were analyzed. Frailty components included: grip strength, gait speed, weight, total energy expenditure, and exhaustion. Longitudinal analysis used mixed effect models.
At baseline, men were sicker with worse cognitive status, and had higher weight and grip strength, but lower total energy expenditure than women (p < 0.001). The prevalence of frailty was 31.5%, 30.2%, and 28.2% at months 2, 6, and 12 respectively, showing no longitudinal trends or sex differences. However, its components showed substantial recovery trends over the post-fracture year after confounding adjustments, including increasing gait speed, reducing risk of exhaustion, and stabilized weight loss and energy expenditure over time. Particularly, while men's grip strength tended to remain stable over first year post surgery within patients, women's grip strength reduced significantly over time within patients. On average over time within patients, women were more active with higher energy expenditures but lower grip strength and weight than men.
Significant recovery trends and sex differences were observed in frailty components during first year post-fracture. Overall frailty status did not show those trends over months 2-12 since a summary measure might obscure changes in components. Therefore, frailty components provided important multi-dimensional information on the complex recovery process of patients, indicating targets for intervention beyond the global binary measure of frailty.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Body weight loss</subject><subject>Cognitive ability</subject><subject>Energy expenditure</subject><subject>Female</subject><subject>Fractures</subject><subject>Frail Elderly - psychology</subject><subject>Frailty</subject><subject>Frailty - epidemiology</subject><subject>Gait</subject><subject>Gender differences</subject><subject>Geriatric Assessment - methods</subject><subject>Hip</subject><subject>Hip Fractures - epidemiology</subject><subject>Hip joint</subject><subject>Hospitalization</subject><subject>Humans</subject><subject>Male</subject><subject>Older people</subject><subject>Prospective Studies</subject><subject>Sex differences</subject><subject>Trends</subject><subject>Women</subject><issn>0002-8614</issn><issn>1532-5415</issn><issn>1532-5415</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkUuLFDEUhYMoTju68A9IgRtd1JhHpSpZiQy-oMGNrkP61k13mqqkTFIj_e9Nz4yDmk0unC-Hc3MIecnoFavn3XGfr5iSWj4iGyYFb2XH5GOyoZTyVvWsuyDPcj5SyjhV6im5EMPAZSf0hrhtDHtf1tEHOzVwsMlCweRz8ZCb6JrlcMoequaS9VM5NTaMjS-5gTgvMWCoow_NjOFW-RXP0xJzaQ5-OT-CsiZ8Tp44O2V8cX9fkh-fPn6__tJuv33-ev1h24LodWk5jL0cgelOyh3STsKw6xwIzpE5JwZbN2LAUWlEJ4cdpwBKCY0MsFOjFpfk_Z3vsu5mHKHGS3YyS_KzTScTrTf_KsEfzD7eGMao4oNi1eHNvUOKP1fMxcw-A06TDRjXbLjq-0Fq0fUVff0feoxrqv9YKc2G6thrUam3dxSkmHNC95CGUXOuz9T6zG19lX31d_wH8k9f4jehCJfz</recordid><startdate>20240101</startdate><enddate>20240101</enddate><creator>Huang, Yi</creator><creator>Orwig, Denise</creator><creator>Hayssen, Hilary</creator><creator>Lu, Wenxin</creator><creator>Gruber-Baldini, Ann L</creator><creator>Chiles Shaffer, Nancy</creator><creator>Magaziner, Jay</creator><creator>Guralnik, Jack M</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-6321-3922</orcidid></search><sort><creationdate>20240101</creationdate><title>Longitudinal characteristics of physical frailty and its components in men and women post hip fracture</title><author>Huang, Yi ; Orwig, Denise ; Hayssen, Hilary ; Lu, Wenxin ; Gruber-Baldini, Ann L ; Chiles Shaffer, Nancy ; Magaziner, Jay ; Guralnik, Jack M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c369t-2cd65dc19455be045c7b4fc322e1ff37a0001c2e89eef57b20cc8839e1ce48d93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Body weight loss</topic><topic>Cognitive ability</topic><topic>Energy expenditure</topic><topic>Female</topic><topic>Fractures</topic><topic>Frail Elderly - psychology</topic><topic>Frailty</topic><topic>Frailty - epidemiology</topic><topic>Gait</topic><topic>Gender differences</topic><topic>Geriatric Assessment - methods</topic><topic>Hip</topic><topic>Hip Fractures - epidemiology</topic><topic>Hip joint</topic><topic>Hospitalization</topic><topic>Humans</topic><topic>Male</topic><topic>Older people</topic><topic>Prospective Studies</topic><topic>Sex differences</topic><topic>Trends</topic><topic>Women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Huang, Yi</creatorcontrib><creatorcontrib>Orwig, Denise</creatorcontrib><creatorcontrib>Hayssen, Hilary</creatorcontrib><creatorcontrib>Lu, Wenxin</creatorcontrib><creatorcontrib>Gruber-Baldini, Ann L</creatorcontrib><creatorcontrib>Chiles Shaffer, Nancy</creatorcontrib><creatorcontrib>Magaziner, Jay</creatorcontrib><creatorcontrib>Guralnik, Jack M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of the American Geriatrics Society (JAGS)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huang, Yi</au><au>Orwig, Denise</au><au>Hayssen, Hilary</au><au>Lu, Wenxin</au><au>Gruber-Baldini, Ann L</au><au>Chiles Shaffer, Nancy</au><au>Magaziner, Jay</au><au>Guralnik, Jack M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Longitudinal characteristics of physical frailty and its components in men and women post hip fracture</atitle><jtitle>Journal of the American Geriatrics Society (JAGS)</jtitle><addtitle>J Am Geriatr Soc</addtitle><date>2024-01-01</date><risdate>2024</risdate><volume>72</volume><issue>1</issue><spage>170</spage><epage>180</epage><pages>170-180</pages><issn>0002-8614</issn><issn>1532-5415</issn><eissn>1532-5415</eissn><abstract>Frailty is an important geriatric syndrome predicting adverse health outcomes in older adults. However, the longitudinal characteristics of frailty components in post-hip fracture patients are less understood. Adopting the Fried frailty definition, we examined the longitudinal trends and sex trajectory differences in frailty and its components over 1 year post-fracture.
Three hundred and twenty-seven hip fracture patients (162 men and 165 women with mean age 80.1 and 81.5) from Baltimore Hip Studies 7th cohort with measurements at 22 days after admission, and months 2, 6, and 12 post-fracture were analyzed. Frailty components included: grip strength, gait speed, weight, total energy expenditure, and exhaustion. Longitudinal analysis used mixed effect models.
At baseline, men were sicker with worse cognitive status, and had higher weight and grip strength, but lower total energy expenditure than women (p < 0.001). The prevalence of frailty was 31.5%, 30.2%, and 28.2% at months 2, 6, and 12 respectively, showing no longitudinal trends or sex differences. However, its components showed substantial recovery trends over the post-fracture year after confounding adjustments, including increasing gait speed, reducing risk of exhaustion, and stabilized weight loss and energy expenditure over time. Particularly, while men's grip strength tended to remain stable over first year post surgery within patients, women's grip strength reduced significantly over time within patients. On average over time within patients, women were more active with higher energy expenditures but lower grip strength and weight than men.
Significant recovery trends and sex differences were observed in frailty components during first year post-fracture. Overall frailty status did not show those trends over months 2-12 since a summary measure might obscure changes in components. Therefore, frailty components provided important multi-dimensional information on the complex recovery process of patients, indicating targets for intervention beyond the global binary measure of frailty.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>37725439</pmid><doi>10.1111/jgs.18595</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-6321-3922</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Aged, 80 and over Body weight loss Cognitive ability Energy expenditure Female Fractures Frail Elderly - psychology Frailty Frailty - epidemiology Gait Gender differences Geriatric Assessment - methods Hip Hip Fractures - epidemiology Hip joint Hospitalization Humans Male Older people Prospective Studies Sex differences Trends Women |
| title | Longitudinal characteristics of physical frailty and its components in men and women post hip fracture |
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