Microglia Autophagy Mediated by TMEM166 Promotes Ischemic Stroke Secondary to Carotid Artery Stenosis

Ischemic stroke can be a serious complication of selective carotid endarterectomy (CEA) in patients with carotid artery stenosis (CAS). The underlying risk factors and mechanisms of these postoperative strokes are not completely understood. Our previous study showed that TMEM166-induced neuronal aut...

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Veröffentlicht in:	Aging and disease 2024-06, Vol.15 (3), p.1416-1431
Hauptverfasser:	Li, Li, Krafft, Paul R, Zeng, Na, Duan, Ranran, Qi, Xiang, Shao, Anwen, Xue, Fushan, Zhang, John H
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Animals Autophagy Autophagy (Cytology) Brain C-Reactive Protein - genetics C-Reactive Protein - metabolism Carotid artery diseases Carotid Stenosis - genetics Carotid Stenosis - metabolism Complications and side effects Development and progression Disease Models, Animal Endarterectomy, Carotid - adverse effects Female Health aspects Humans Injuries Interleukins Ischemia Ischemic Stroke - genetics Ischemic Stroke - metabolism Ischemic Stroke - pathology Male Membrane proteins Membrane Proteins - genetics Membrane Proteins - metabolism Mice Mice, Knockout Microglia - metabolism Microglia - pathology Middle Aged Neurons Original Physiological aspects Proteins Risk factors Stenosis Stroke (Disease) TOR Serine-Threonine Kinases - genetics TOR Serine-Threonine Kinases - metabolism
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