Lethal eosinophilic crystalline pneumonia in mice expressing a stabilized Csf2 mRNA

Granulocyte–macrophage colony‐stimulating factor (GM‐CSF) is a cytokine that stimulates the proliferation and differentiation of granulocyte and macrophage precursors. The mouse gene‐encoding GM‐CSF, Csf2, is regulated at both transcriptional and post‐transcriptional levels. An adenine–uridine‐rich...

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Veröffentlicht in:	The FASEB journal 2023-08, Vol.37 (8), p.e23100-n/a
Hauptverfasser:	Arao, Yukitomo, Stumpo, Deborah J., Hoenerhoff, Mark J., Tighe, Robert M., Yu, Yen‐Rei, Sutton, Deloris, Kashyap, Amogh, Beerman, Isabel, Blackshear, Perry J.
Format:	Artikel
Sprache:	eng
Schlagworte:	3′‐untranslated region alveolar macrophage Animals AU‐rich element eosinophilic crystalline pneumonia GM‐CSF Granulocyte-Macrophage Colony-Stimulating Factor - genetics Granulocyte-Macrophage Colony-Stimulating Factor - metabolism Lung - metabolism Macrophages, Alveolar - metabolism Mice mRNA stability Pneumonia - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism
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