The role of quiescent thymic progenitors in TAL/LMO2-induced T-ALL chemotolerance

Relapse in T-cell acute lymphoblastic leukemia (T-ALL) may signify the persistence of leukemia-initiating cells (L-ICs). Ectopic TAL1/LMO expression defines the largest subset of T-ALL, but its role in leukemic transformation and its impact on relapse-driving L-ICs remain poorly understood. In TAL1...

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Veröffentlicht in:	Leukemia 2024-05, Vol.38 (5), p.951-962
Hauptverfasser:	O’Connor, Kevin W., Kishimoto, Kensei, Kuzma, Irena O., Wagner, Kelsey P., Selway, Jonathan S., Roderick, Justine E., Karna, Keshab K., Gallagher, Kayleigh M., Hu, Kai, Liu, Haibo, Li, Rui, Brehm, Michael A., Zhu, Lihua Julie, Curtis, David J., Tremblay, Cedric S., Kelliher, Michelle A.
Format:	Artikel
Sprache:	eng
Schlagworte:	38/39 38/91 45 631/67/1059/99 631/67/1990/283/2125 631/67/395 631/67/70 631/67/71 64 64/60 Acute lymphoblastic leukemia Animal models Cancer Research CD25 antigen CD4 antigen CD44 antigen CD7 antigen CD8 antigen Cell culture Cell cycle Critical Care Medicine Gene sequencing Genes Genetic transformation Hematology Heterogeneity In vivo methods and tests Intensive Internal Medicine Leukemia Leukemogenesis Lymphocytes T Medicine Medicine & Public Health Minimal residual disease Oncology Thymus
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