A53T mutant α-synuclein fibrils formed in macrophage are spread to neurons

Lewy body (LB), which mainly consists of abnormal α-synuclein (αS) aggregates, is a histological hallmark of Parkinson’s disease (PD). αS aggregation and LB inclusions are induced by spreading αS fibrils to neurons; therefore, the formation and transmission of αS fibrils to neurons may play an essen...

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Veröffentlicht in:	Cellular and molecular life sciences : CMLS 2022-05, Vol.79 (5), p.234-234, Article 234
Hauptverfasser:	Moriya, Shogo, Hanazono, Michiko, Fukuhara, Takeshi, Iwase, Katsuro, Hattori, Nobutaka, Takiguchi, Masaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Aggregates alpha-Synuclein - genetics alpha-Synuclein - metabolism Animals Animals, Genetically Modified Axonal transport Biochemistry Biomedical and Life Sciences Biomedicine Cell Biology Danio rerio Fibrils Genes Humans Inclusion Bodies - metabolism Inclusions Kinases Lewy bodies Life Sciences Macrophages Macrophages - metabolism Microglia Monomers Movement disorders Neurodegenerative diseases Neurons Neurons - metabolism Original Original Article Parkinson Disease - pathology Parkinson's disease Pathogenesis Proteasomes Synuclein THP-1 Cells Transcriptomes Transgenic animals Ubiquitin Ubiquitin-protein ligase Zebrafish Zebrafish - genetics Zebrafish - metabolism
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