Dietary intake of α-ketoglutarate ameliorates α-synuclein pathology in mouse models of Parkinson’s disease

Parkinson’s disease (PD) is a progressive movement disorder characterized by dopaminergic (DA) neuron degeneration and the existence of Lewy bodies formed by misfolded α-synuclein. Emerging evidence supports the benefits of dietary interventions in PD due to their safety and practicality. Previously...

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Veröffentlicht in:	Cellular and molecular life sciences : CMLS 2023-06, Vol.80 (6), p.155-155, Article 155
Hauptverfasser:	Zhang, Wenlong, Ding, Liuyan, Zhang, Mengran, Zheng, Shaohui, Ma, Runfang, Gong, Junwei, Mao, Hengxu, Xu, Huaxi, Xu, Pingyi, Zhang, Yunlong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Biochemistry Biomedical and Life Sciences Biomedicine Cell Biology Degeneration Dependoparvovirus Diet Dietary intake digestive system Disease Models, Animal Docosahexaenoic acid Dopamine Dopamine receptors Eating fatty acid metabolism Fatty acids Food intake genetically modified organisms Humans Inflammation Ketoglutaric acid Ketoglutaric Acids - pharmacology Lewy bodies Life Sciences Life span longevity Mice Mice, Transgenic Microglia microorganisms Movement disorders Nerve Degeneration - pathology Neurodegeneration Neurodegenerative diseases neuroglia Original Original Article Parkinson Disease - pathology Parkinson's disease Pathology Polyunsaturated fatty acids Protected species species Substantia nigra Synapses Synuclein Synucleinopathies therapeutics Transgenic mice
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