Recombinant thrombomodulin domain 1 rescues pathological angiogenesis by inhibition of HIF-1α-VEGF pathway

Pathological angiogenesis (PA) contributes to various ocular diseases, including age-related macular degeneration, diabetic retinopathy, and retinopathy of prematurity, which are major causes of blindness over the world. Current treatments focus on anti-vascular endothelial growth factor (VEGF) ther...

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Veröffentlicht in:	Cellular and molecular life sciences : CMLS 2021-12, Vol.78 (23), p.7681-7692
Hauptverfasser:	Huang, Yi-Hsun, Kuo, Cheng-Hsiang, Peng, I-Chen, Chang, Yi-Sheng, Tseng, Sung-Huei, Conway, Edward M., Wu, Hua-Lin
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Age related diseases Angiogenesis Animal models Animals Apoptosis Biochemistry Biomedical and Life Sciences Biomedicine Blindness Cell adhesion Cell Biology Cell Movement Cell Proliferation Cells, Cultured Chemical compounds Diabetes mellitus Diabetic retinopathy Eye diseases Female Gene Expression Regulation Growth factors Health services Humans Hypoxia Hypoxia-Inducible Factor 1, alpha Subunit - antagonists & inhibitors Hypoxia-Inducible Factor 1, alpha Subunit - genetics Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Hypoxia-inducible factor 1a Inflammation Intercellular adhesion molecule 1 Interleukin 6 Life Sciences Macular degeneration Male Mice Mice, Inbred C57BL Mice, Knockout Neovascularization, Pathologic - genetics Neovascularization, Pathologic - metabolism Neovascularization, Pathologic - pathology Neovascularization, Pathologic - prevention & control Original Original Article Pharmacology Retina Retinal Neovascularization - genetics Retinal Neovascularization - metabolism Retinal Neovascularization - pathology Retinal Neovascularization - prevention & control Retinopathy Thrombomodulin Thrombomodulin - genetics Thrombomodulin - metabolism Vascular endothelial growth factor Vascular Endothelial Growth Factor A - antagonists & inhibitors Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor A - metabolism Vascularization
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