An overview of signaling pathways regulating YAP/TAZ activity
YAP and TAZ are ubiquitously expressed homologous proteins originally identified as penultimate effectors of the Hippo signaling pathway, which plays a key role in maintaining mammalian tissue/organ size. Presently, it is known that YAP/TAZ also interact with various non-Hippo signaling pathways, an...
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| Veröffentlicht in: | Cellular and molecular life sciences : CMLS 2021-01, Vol.78 (2), p.497-512 |
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| creator | Heng, Boon Chin Zhang, Xuehui Aubel, Dominique Bai, Yunyang Li, Xiaochan Wei, Yan Fussenegger, Martin Deng, Xuliang |
| description | YAP and TAZ are ubiquitously expressed homologous proteins originally identified as penultimate effectors of the Hippo signaling pathway, which plays a key role in maintaining mammalian tissue/organ size. Presently, it is known that YAP/TAZ also interact with various non-Hippo signaling pathways, and have diverse roles in multiple biological processes, including cell proliferation, tissue regeneration, cell lineage fate determination, tumorigenesis, and mechanosensing. In this review, we first examine the various microenvironmental cues and signaling pathways that regulate YAP/TAZ activation, through the Hippo and non-Hippo signaling pathways. This is followed by a brief summary of the interactions of YAP/TAZ with TEAD1-4 and a diverse array of other non-TEAD transcription factors. Finally, we offer a critical perspective on how increasing knowledge of the regulatory mechanisms of YAP/TAZ signaling might open the door to novel therapeutic applications in the interrelated fields of biomaterials, tissue engineering, regenerative medicine and synthetic biology. |
| doi_str_mv | 10.1007/s00018-020-03579-8 |
| format | Article |
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Presently, it is known that YAP/TAZ also interact with various non-Hippo signaling pathways, and have diverse roles in multiple biological processes, including cell proliferation, tissue regeneration, cell lineage fate determination, tumorigenesis, and mechanosensing. In this review, we first examine the various microenvironmental cues and signaling pathways that regulate YAP/TAZ activation, through the Hippo and non-Hippo signaling pathways. This is followed by a brief summary of the interactions of YAP/TAZ with TEAD1-4 and a diverse array of other non-TEAD transcription factors. Finally, we offer a critical perspective on how increasing knowledge of the regulatory mechanisms of YAP/TAZ signaling might open the door to novel therapeutic applications in the interrelated fields of biomaterials, tissue engineering, regenerative medicine and synthetic biology.</description><identifier>ISSN: 1420-682X</identifier><identifier>EISSN: 1420-9071</identifier><identifier>DOI: 10.1007/s00018-020-03579-8</identifier><identifier>PMID: 32748155</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Adaptor Proteins, Signal Transducing - metabolism ; Animals ; Biochemistry ; Biological activity ; Biomaterials ; Biomedical and Life Sciences ; Biomedical materials ; Biomedicine ; Carcinogenesis - metabolism ; Cell Biology ; Cell Communication ; Cell lineage ; Cell proliferation ; Hippo Signaling Pathway ; Homology ; Humans ; Kinases ; Life Sciences ; Protein Interaction Maps ; Protein Serine-Threonine Kinases - metabolism ; Receptors, Notch - metabolism ; Regeneration (physiology) ; Regenerative medicine ; Regulatory mechanisms (biology) ; Review ; Signal Transduction ; Signaling ; Therapeutic applications ; Tissue engineering ; Trans-Activators - metabolism ; Transcription factors ; Transcription Factors - metabolism ; Transcriptional Coactivator with PDZ-Binding Motif Proteins ; Tumorigenesis ; YAP-Signaling Proteins ; Yes-associated protein</subject><ispartof>Cellular and molecular life sciences : CMLS, 2021-01, Vol.78 (2), p.497-512</ispartof><rights>Springer Nature Switzerland AG 2020</rights><rights>Springer Nature Switzerland AG 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c431t-102ad7095f20dd5bc7a5e9ab53235b5690b4dbecee803a3fc03a2549bda1b3103</citedby><cites>FETCH-LOGICAL-c431t-102ad7095f20dd5bc7a5e9ab53235b5690b4dbecee803a3fc03a2549bda1b3103</cites><orcidid>0000-0003-1838-6274</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11071991/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11071991/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,41488,42557,51319,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32748155$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Heng, Boon Chin</creatorcontrib><creatorcontrib>Zhang, Xuehui</creatorcontrib><creatorcontrib>Aubel, Dominique</creatorcontrib><creatorcontrib>Bai, Yunyang</creatorcontrib><creatorcontrib>Li, Xiaochan</creatorcontrib><creatorcontrib>Wei, Yan</creatorcontrib><creatorcontrib>Fussenegger, Martin</creatorcontrib><creatorcontrib>Deng, Xuliang</creatorcontrib><title>An overview of signaling pathways regulating YAP/TAZ activity</title><title>Cellular and molecular life sciences : CMLS</title><addtitle>Cell. Mol. Life Sci</addtitle><addtitle>Cell Mol Life Sci</addtitle><description>YAP and TAZ are ubiquitously expressed homologous proteins originally identified as penultimate effectors of the Hippo signaling pathway, which plays a key role in maintaining mammalian tissue/organ size. Presently, it is known that YAP/TAZ also interact with various non-Hippo signaling pathways, and have diverse roles in multiple biological processes, including cell proliferation, tissue regeneration, cell lineage fate determination, tumorigenesis, and mechanosensing. In this review, we first examine the various microenvironmental cues and signaling pathways that regulate YAP/TAZ activation, through the Hippo and non-Hippo signaling pathways. This is followed by a brief summary of the interactions of YAP/TAZ with TEAD1-4 and a diverse array of other non-TEAD transcription factors. Finally, we offer a critical perspective on how increasing knowledge of the regulatory mechanisms of YAP/TAZ signaling might open the door to novel therapeutic applications in the interrelated fields of biomaterials, tissue engineering, regenerative medicine and synthetic biology.</description><subject>Adaptor Proteins, Signal Transducing - metabolism</subject><subject>Animals</subject><subject>Biochemistry</subject><subject>Biological activity</subject><subject>Biomaterials</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedical materials</subject><subject>Biomedicine</subject><subject>Carcinogenesis - metabolism</subject><subject>Cell Biology</subject><subject>Cell Communication</subject><subject>Cell lineage</subject><subject>Cell proliferation</subject><subject>Hippo Signaling Pathway</subject><subject>Homology</subject><subject>Humans</subject><subject>Kinases</subject><subject>Life Sciences</subject><subject>Protein Interaction Maps</subject><subject>Protein Serine-Threonine Kinases - metabolism</subject><subject>Receptors, Notch - metabolism</subject><subject>Regeneration (physiology)</subject><subject>Regenerative medicine</subject><subject>Regulatory mechanisms (biology)</subject><subject>Review</subject><subject>Signal Transduction</subject><subject>Signaling</subject><subject>Therapeutic applications</subject><subject>Tissue engineering</subject><subject>Trans-Activators - metabolism</subject><subject>Transcription factors</subject><subject>Transcription Factors - metabolism</subject><subject>Transcriptional Coactivator with PDZ-Binding Motif Proteins</subject><subject>Tumorigenesis</subject><subject>YAP-Signaling Proteins</subject><subject>Yes-associated protein</subject><issn>1420-682X</issn><issn>1420-9071</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kE1PwzAMhiMEYmPwBzigSpzLnKRp0wNC1cSXNAkOQwIuUdqmXaeuHUnbaf-ejI4BFy5JbL9-7TwInWO4wgDB2AAA5i4QcIGyIHT5ARpiz4YhBPhw9_Y5eR2gE2MWVs048Y_RgJLA45ixIbqOKqfulO4KtXbqzDFFXsmyqHJnJZv5Wm6Mo1XelrLZ5t6i5_Esendk0hRd0WxO0VEmS6POdvcIvdzdziYP7vTp_nESTd3Eo7hxMRCZBhCyjECasjgJJFOhjBkllMXMDyH20lglSnGgkmaJPQnzwjiVOKYY6Ajd9L6rNl6qNFFVo2UpVrpYSr0RtSzE30pVzEVedwJjSyIMsXW43Dno-qNVphGLutX2q0YQjwc-ZT6mVkV6VaJrY7TK9iMwiC1z0TMXlrn4Yi64bbr4vdy-5RuyFdBeYGypypX-mf2P7SefJI0I</recordid><startdate>20210101</startdate><enddate>20210101</enddate><creator>Heng, Boon Chin</creator><creator>Zhang, Xuehui</creator><creator>Aubel, Dominique</creator><creator>Bai, Yunyang</creator><creator>Li, Xiaochan</creator><creator>Wei, Yan</creator><creator>Fussenegger, Martin</creator><creator>Deng, Xuliang</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SS</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>P64</scope><scope>PATMY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>RC3</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-1838-6274</orcidid></search><sort><creationdate>20210101</creationdate><title>An overview of signaling pathways regulating YAP/TAZ activity</title><author>Heng, Boon Chin ; Zhang, Xuehui ; Aubel, Dominique ; Bai, Yunyang ; Li, Xiaochan ; Wei, Yan ; Fussenegger, Martin ; Deng, Xuliang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c431t-102ad7095f20dd5bc7a5e9ab53235b5690b4dbecee803a3fc03a2549bda1b3103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adaptor Proteins, Signal Transducing - 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Mol. Life Sci</stitle><addtitle>Cell Mol Life Sci</addtitle><date>2021-01-01</date><risdate>2021</risdate><volume>78</volume><issue>2</issue><spage>497</spage><epage>512</epage><pages>497-512</pages><issn>1420-682X</issn><eissn>1420-9071</eissn><abstract>YAP and TAZ are ubiquitously expressed homologous proteins originally identified as penultimate effectors of the Hippo signaling pathway, which plays a key role in maintaining mammalian tissue/organ size. Presently, it is known that YAP/TAZ also interact with various non-Hippo signaling pathways, and have diverse roles in multiple biological processes, including cell proliferation, tissue regeneration, cell lineage fate determination, tumorigenesis, and mechanosensing. In this review, we first examine the various microenvironmental cues and signaling pathways that regulate YAP/TAZ activation, through the Hippo and non-Hippo signaling pathways. This is followed by a brief summary of the interactions of YAP/TAZ with TEAD1-4 and a diverse array of other non-TEAD transcription factors. Finally, we offer a critical perspective on how increasing knowledge of the regulatory mechanisms of YAP/TAZ signaling might open the door to novel therapeutic applications in the interrelated fields of biomaterials, tissue engineering, regenerative medicine and synthetic biology.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>32748155</pmid><doi>10.1007/s00018-020-03579-8</doi><tpages>16</tpages><orcidid>https://orcid.org/0000-0003-1838-6274</orcidid></addata></record> |
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| source | Open Access: PubMed Central; MEDLINE; Springer Nature |
| subjects | Adaptor Proteins, Signal Transducing - metabolism Animals Biochemistry Biological activity Biomaterials Biomedical and Life Sciences Biomedical materials Biomedicine Carcinogenesis - metabolism Cell Biology Cell Communication Cell lineage Cell proliferation Hippo Signaling Pathway Homology Humans Kinases Life Sciences Protein Interaction Maps Protein Serine-Threonine Kinases - metabolism Receptors, Notch - metabolism Regeneration (physiology) Regenerative medicine Regulatory mechanisms (biology) Review Signal Transduction Signaling Therapeutic applications Tissue engineering Trans-Activators - metabolism Transcription factors Transcription Factors - metabolism Transcriptional Coactivator with PDZ-Binding Motif Proteins Tumorigenesis YAP-Signaling Proteins Yes-associated protein |
| title | An overview of signaling pathways regulating YAP/TAZ activity |
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