MED12 is overexpressed in glioblastoma patients and serves as an oncogene by targeting the VDR/BCL6/p53 axis

Glioblastoma is the most life-threatening tumor of the central nervous system. Despite recent therapeutic advancements, maximum survival of glioblastoma patients remains dismal. The mediator complex is a set of proteins, essential for eukaryotic gene expression. Abnormal expression/mutations of spec...

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Veröffentlicht in:	Cellular and molecular life sciences : CMLS 2022-02, Vol.79 (2), p.104-104, Article 104
Hauptverfasser:	Srivastava, Srishti, Makala, Hima, Sharma, Vikas, Suri, Vaishali, Sarkar, Chitra, Kulshreshtha, Ritu
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Apoptosis - genetics Bcl-6 protein Biochemistry Biomedical and Life Sciences Biomedicine Brain cancer Brain Neoplasms - genetics Brain Neoplasms - metabolism Brain Neoplasms - pathology Cell Biology Cell Line, Tumor Cell migration Cell proliferation Central nervous system Chromatin Gene expression Gene Expression Profiling - methods Gene Expression Regulation, Neoplastic Glioblastoma Glioblastoma - genetics Glioblastoma - metabolism Glioblastoma - pathology Humans Immunoprecipitation Kaplan-Meier Estimate Kinases Life Sciences Mediator Complex - genetics Mediator Complex - metabolism Mutation Oncogenes Oncogenes - genetics Original Original Article Overexpression p53 Protein Pathogenesis Prognosis Protein Binding Proteins Proto-Oncogene Proteins c-bcl-6 - genetics Proto-Oncogene Proteins c-bcl-6 - metabolism Receptors, Calcitriol - genetics Receptors, Calcitriol - metabolism RNA Interference Signal transduction Signaling Therapeutic applications Transcriptomes Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Tumors Vitamin D Vitamin D receptors
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