TRAF6-mediated ubiquitination of MST1/STK4 attenuates the TLR4-NF-κB signaling pathway in macrophages

Pattern-recognition receptors including Toll-like receptors (TLRs) recognize invading pathogens and trigger an immune response in mammals. Here we show that mammalian ste20-like kinase 1/serine/threonine kinase 4 (MST1/STK4) functions as a negative regulator of lipopolysaccharide (LPS)-induced activ...

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Veröffentlicht in:	Cellular and molecular life sciences : CMLS 2021-03, Vol.78 (5), p.2315-2328
Hauptverfasser:	Roh, Kyung-Hye, Lee, Yeojin, Yoon, Je-Hyun, Lee, Danbi, Kim, Eunju, Park, Eunchong, Lee, In Young, Kim, Tae Sung, Song, Hyun Kyu, Shin, Jaekyoon, Lim, Dae-Sik, Choi, Eui-Ju
Format:	Artikel
Sprache:	eng
Schlagworte:	Ablation Animals Biochemistry Biomedical and Life Sciences Biomedicine Bone marrow Cell activation Cell Biology Cells, Cultured Cytokines Cytokines - blood Cytokines - genetics Cytokines - metabolism HEK293 Cells Humans Immune response Immune system Inflammation Kinases Life Sciences Lipopolysaccharides Lipopolysaccharides - pharmacology Macrophage Activation - drug effects Macrophages Macrophages - cytology Macrophages - drug effects Macrophages - metabolism Mammals Mice Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Negative feedback NF-kappa B - metabolism NF-κB protein Original Original Article Pattern recognition Protein Serine-Threonine Kinases - genetics Protein Serine-Threonine Kinases - metabolism Protein-serine/threonine kinase Proteins Receptors Sepsis - blood Sepsis - genetics Sepsis - metabolism Septic shock Sequestosome-1 Protein - genetics Sequestosome-1 Protein - metabolism Signal transduction Signal Transduction - drug effects Signaling Survival Analysis TLR4 protein TNF Receptor-Associated Factor 6 - genetics TNF Receptor-Associated Factor 6 - metabolism Toll-Like Receptor 4 - genetics Toll-Like Receptor 4 - metabolism Toll-like receptors TRAF6 protein Ubiquitination Ubiquitination - drug effects
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