α-Klotho released from HK-2 cells inhibits osteogenic differentiation of renal interstitial fibroblasts by inactivating the Wnt–β-catenin pathway

Randall’s plaques (RP) are well established as precursor lesions of idiopathic calcium oxalate (CaOx) stones, and the process of biomineralization driven by osteogenic-like cells has been highlighted in RP formation, but the mechanism is poorly understood. Given the inhibitory role of α-Klotho (KL),...

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Veröffentlicht in:	Cellular and molecular life sciences : CMLS 2021-12, Vol.78 (23), p.7831-7849
Hauptverfasser:	Zhu, Zewu, Ruan, Shuhao, Jiang, Yingcheng, Huang, Fang, Xia, Weiping, Chen, Jinbo, Cui, Yu, He, Cheng, Zeng, Feng, Li, Yang, Chen, Zhiyong, Chen, Hequn
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging agonists Animals beta Catenin - antagonists & inhibitors beta Catenin - genetics beta Catenin - metabolism Biochemistry Biomedical and Life Sciences Biomedical materials Biomedicine biomineralization bone formation Calcification Calcification (ectopic) Calcium oxalate Cell Biology Cell Differentiation coculture Deactivation Differentiation (biology) Dkk1 protein Epithelial cells Epithelium Fibroblasts Fibroblasts - metabolism Fibroblasts - pathology Frizzled-related protein 1 Gene Expression Regulation Gene polymorphism genes Humans Intercellular Signaling Peptides and Proteins - genetics Intercellular Signaling Peptides and Proteins - metabolism Interstitial cells Kidney Calculi - genetics Kidney Calculi - metabolism Kidney Calculi - pathology Kidney Medulla - metabolism Kidney Medulla - pathology Kidney stones Kidneys Klotho protein Klotho Proteins - genetics Klotho Proteins - metabolism Life Sciences Lithiasis Membrane Proteins - genetics Membrane Proteins - metabolism Mice Mice, Nude Mineralization Original Original Article Osteogenesis Oxalic acid Plaques Urolithiasis Wnt protein wnt proteins Wnt Proteins - antagonists & inhibitors Wnt Proteins - genetics Wnt Proteins - metabolism β-Catenin
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