Insertion of a nuclear factor kappa B DNA nuclear-targeting sequence potentiates suicide gene therapy efficacy in lung cancer cell lines

Lung cancer currently causes the majority of cancer-related deaths worldwide and new treatments are in high demand. Gene therapy could be a promising treatment but currently lacks sufficient efficiency for clinical use, primarily due to limited cellular and nuclear DNA delivery. In the present study...

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Veröffentlicht in:	Cancer gene therapy 2012-10, Vol.19 (10), p.675-683
Hauptverfasser:	Cramer, F, Christensen, C L, Poulsen, T T, Badding, M A, Dean, D A, Poulsen, H S
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/2489/201 692/699/67/1612 Analysis Binding sites Biomedical and Life Sciences Biomedicine Cancer therapies Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - therapy Care and treatment Cell Line, Tumor Cell lines Cell Survival Deoxyribonucleic acid DNA DNA sequencing Gene Expression Gene Therapy Genes, Transgenic, Suicide Genetic Therapy - methods Health aspects Humans Lung cancer Lung Neoplasms - genetics Lung Neoplasms - metabolism Lung Neoplasms - therapy NF-kappa B - genetics NF-kappa B - metabolism NF-κB protein Nuclear transport Nucleotide sequence Nucleotide sequencing original-article Physiological aspects Plasmids Small cell lung carcinoma Small Cell Lung Carcinoma - genetics Small Cell Lung Carcinoma - metabolism Small Cell Lung Carcinoma - therapy Suicide genes Transcription Transfection Tumor cell lines
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