Development of a CD163-Targeted PET Radiotracer That Images Resident Macrophages in Atherosclerosis

Tissue-resident macrophages are complementary to proinflammatory macrophages to promote the progression of atherosclerosis. The noninvasive detection of their presence and dynamic variation will be important to the understanding of their role in the pathogenesis of atherosclerosis. The goal of this...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of Nuclear Medicine 2024-05, Vol.65 (5), p.775-780
Hauptverfasser:	Zhang, Xiuli, Heo, Gyu Seong, Li, Alexandria, Lahad, Divangana, Detering, Lisa, Tao, Joan, Gao, Xuefeng, Zhang, Xiaohui, Luehmann, Hannah, Sultan, Deborah, Lou, Lanlan, Venkatesan, Rajiu, Li, Ran, Zheng, Jie, Amrute, Junedh, Lin, Chieh-Yu, Kopecky, Benjamin J, Gropler, Robert J, Bredemeyer, Andrea, Lavine, Kory, Liu, Yongjian
Format:	Artikel
Sprache:	eng
Schlagworte:	Affinity Animal models Animals Antigens, CD - metabolism Antigens, Differentiation, Myelomonocytic - metabolism Apolipoprotein E Arteriosclerosis Atherosclerosis Atherosclerosis - diagnostic imaging Atherosclerosis - metabolism Autoradiography Basic Science Investigation Binding Biodistribution Biomarkers CD163 antigen Copper Radioisotopes Flow cytometry Gene expression Gene sequencing Human tissues Humans Imaging Inflammation Injection Lesions Macrophages Macrophages - metabolism Mice Mice, Inbred C57BL Pathogenesis Phage display Plaques Positron emission Positron-Emission Tomography - methods Radioactive tracers Radiolabelling Radiopharmaceuticals - pharmacokinetics Receptors, Cell Surface - metabolism Sensitivity Tissue Distribution
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!