Quorum-sensing regulation of phenazine production heightens Pseudomonas aeruginosa resistance to ciprofloxacin

Quorum sensing is a type of cell-cell communication that modulates various biological activities of bacteria. Previous studies indicate that quorum sensing contributes to the evolution of bacterial resistance to antibiotics, but the underlying mechanisms are not fully understood. In this study, we g...

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Veröffentlicht in:	Antimicrobial agents and chemotherapy 2024-05, Vol.68 (5), p.e0011824
Hauptverfasser:	Xia, Lexin, Li, Yue, Wang, Yufan, Zhou, Hui, Dandekar, Ajai A, Wang, Meizhen, Xu, Feng
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - pharmacology Antimicrobial Chemotherapy Ciprofloxacin - pharmacology Drug Resistance, Bacterial - genetics Gene Expression Regulation, Bacterial - drug effects Mechanisms of Resistance Microbial Sensitivity Tests Phenazines - metabolism Phenazines - pharmacology Pseudomonas aeruginosa - drug effects Pseudomonas aeruginosa - genetics Pyocyanine - biosynthesis Quinolones - pharmacology Quorum Sensing - drug effects
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