Preconditioning-Induced Facilitation of Lactate Release from Astrocytes Is Essential for Brain Ischemic Tolerance

A sublethal ischemic episode [termed preconditioning (PC)] protects neurons in the brain against a subsequent severe ischemic injury. This phenomenon is known as brain ischemic tolerance and has received much attention from researchers because of its robust neuroprotective effects. We have previousl...

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Veröffentlicht in:	eNeuro 2024-04, Vol.11 (4), p.ENEURO.0494-23.2024
Hauptverfasser:	Hirayama, Yuri, Le, Ha Pham Ngoc, Hashimoto, Hirofumi, Ishii, Itsuko, Koizumi, Schuichi, Anzai, Naohiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Adenosine Triphosphate - pharmacology Animals Astrocytes - drug effects Astrocytes - metabolism Basigin - metabolism Brain - metabolism Brain Ischemia - metabolism Cells, Cultured Disease Models, Animal Infarction, Middle Cerebral Artery - metabolism Ischemic Preconditioning - methods Lactic Acid - metabolism Lactic Acid - pharmacology Male Mice Mice, Inbred C57BL Mice, Knockout Monocarboxylic Acid Transporters - metabolism Muscle Proteins - metabolism New Research Receptors, Purinergic P2X7 - metabolism Symporters - metabolism
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