Potentiating the radiation-induced type I interferon antitumoral immune response by ATM inhibition in pancreatic cancer

Radiotherapy induces a type I interferon-mediated (T1IFN-mediated) antitumoral immune response that we hypothesized could be potentiated by a first-in-class ataxia telangiectasia mutated (ATM) inhibitor, leading to enhanced innate immune signaling, T1IFN expression, and sensitization to immunotherap...

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Veröffentlicht in:	JCI insight 2024-02, Vol.9 (6)
Hauptverfasser:	Zhang, Qiang, Jiang, Long, Wang, Weiwei, Huber, Amanda K, Valvo, Victoria M, Jungles, Kassidy M, Holcomb, Erin A, Pearson, Ashley N, The, Stephanie, Wang, Zhuwen, Parsels, Leslie A, Parsels, Joshua D, Wahl, Daniel R, Rao, Arvind, Sahai, Vaibhav, Lawrence, Theodore S, Green, Michael D, Morgan, Meredith A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Ataxia Telangiectasia Immunity Interferon Type I Mice Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - pathology Pancreatic Neoplasms - radiotherapy Pyridines Quinolones
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